Search results for: 'Arginin'

Chain Extension: Discover Homo Amino Acids

We expanded our portfolio of Fmoc-protected homo amino acids . Benefit of their unique properties to modulate the stability, hydrophobicity, and biological performance of your peptide!

PotM: Versatile TentaGel® Resins

Discover the diversity of TentaGel® Resins ! Read our blog to get more information about our latest product additions and possible applications and find the right resin for your research endeavors!

Bioisosteric Argininine Analogs

Same but different! Expand your possibilities for peptide modification and fine-tuning by implementing N ω -carbamoylated arginine building blocks as bioisosteric arginine analogs.

Bifunctional TentaGel® Resins

Encode beads with unique tags for combinatorial syntheses & screening. Build libraries & identify hits. Discover properties and applications of our novel bifunctional TentaGel® resins.

Carboxymethyl Amino Acid Derivatives

Level up! Carboxymethyl-modified amino acid building blocks suitable for incorporation by solid-phase peptide synthesis. Learn more about available derivatives and their properties.

Selective Lysine Labeling with Squaric Acid

Keeping control! PEGylating reagents with a squaric acid ethyl ester react chemoselectively with side chain amino functions of surface-accessible Lysines in proteins. Other functionalities are not affected.

PotM: Argpyrimidine Building Block for SPPS

Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!

PotM: Biotin – Desthiobiotin - Iminobiotin

Herein, we present 2-Iminobiotin, a cyclic guanidino analogue of biotin with pH-dependent affinity for avidin, and compare it to biotin and desthiobiotin. Click here for more detailed information.

Workshop Polymer Therapeutics for Improved Drug Delivery

You missed our workshop featuring Prof. María Jesus Vicent Docón (Head of Polymer Therapeutics Lab)? Any further questions? Please get in contact via info@iris-biotech.de.

Drug Delivery at Iris Biotech

Discover our products suitable for drug delivery including poly ethyleneglycols (PEGs), poly amino acids (PArg, PGlu, PLys, POR, PSar), poly(oxazoline)s, as well as fullerenes. Read on to find out more!

Measures to Prevent Aspartimide Formation

Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.

Innovative ways to fight SARS-CoV-2

With the approval of several COVID-19 vaccines and drugs in recent months, hope is growing that the current pandemic will end soon.

PotM: Pyridyldithiols as Precursors for Disulfide-Based (Self-Immolative) Linkers

Read on to find out more about Iris Biotech’s Linkerology® portfolio including substituted pyridyldithiols as building blocks for the reversible chemical conjugation to sulfhydryls.

PotM: Guanidino-Proline as rigid Arginine mimic

Interested in structure activity studies on your Arginine containing peptide or further optimization for improved receptor binding? Explore our guanidino Proline derivatives as rigid Arginine mimics.

Arginine Derivatives Suitable for Side-Chain Derivatization

Herein we present two arginine derivatives, in which the native guanidino group is replaced by an isosteric amino-functionalized carbamoylated guanidino group that can serve as an attachment point for further derivatization.

Fighting SARS-CoV-2

Fighting COVID-19 by modifying essential viral proteins via glycation through methylglyoxal – a reactive carbonyl compound known from the Maillard reaction. Read on to find out more!

Product Focus: Arginine Derivatives

Looking to optimize or functionalize your peptide? Explore our ever-growing selection of Arg derivatives and find the one suitable for your application.

Product of the Month: Dde-based Linkers

Placing Dde as one terminal group of a linker and a functional group prone for conjugation as the other or using Dde as the central connective portion of a linker, allows for the creation of new bifunctional linkers.

Product of the Month: cyclo-Arg-Gly-Asp (RGD) Peptides

The integrin receptor interacting RGD sequence and related peptides act as promising tools for drug therapy and cancer research. Find more information on our portfolio of cyclic RGD peptides.

Short arginine analogs: peptide synthesis prediction of biological effects

Arginine, a semi-essential amino acid, is involved in various important metabolic processes.

Influence of arginine mimetics on the biological effects of NT(8-13) analogues

S. Mihaylova, M. Georgieva, T. Bruckdorfer, T. Pajpanova Conference Paper: 35th European Peptide Symposium 2018; https://doi.org/10.17952/35EPS.2018.257

Amadori & Maillard reaction derived peptides

Find below derivatives of arginine and lysine bearing side chains as found in Maillard reaction products.

ISMR13 - 13th International Symposium on the Maillard Reaction

10-13 September 2018

Polyarginine

Polyarginines are well known for their ability to enhance cell penetration.

Arginine Analogues

Trypsin (EC 3.4.21.4), an endopeptidase and natural protease found in the digestive system, cleaves peptide chains and proteins predominantly at the carboxyl side of the amino acids Lys and Arg (except when followed by Pro).

Maillard Reaction Products

Proteins contained in meat and other comestible goods are usually rich in the amino acids arginine and lysine. The side chain func- tional groups of Arg and Lys react with reducing carbohydrates such as glucose or lactose to form Amadori reaction products.

Polymers Enlarge the Potential of Biopharmaceuticals

The Biopharmaceuticals market, estimated at US$ 200 billion globally in 2013 by reportbuyer.com (Biopharmaceuticals - A Global Market Overview, 2013, London), is further projected to reach US$ 500 billion by 2020, growing at 13.5 % CAGR between 2010 and 2020.

Markers for the Quality of Food

Maillard Reaction Products (MRPs) result from the reaction of Arg and Lys side chains with reducing carbohydrates. MRPs are valuable markers for food quality and are used in many different branches of industry such as food, pharma, cosmetics and biochemistry.

Inexpensive & High Quality Guanylation Reagents

We now offer N,N' -Bis-Boc- N" -triflylguanidine , at both a very competitive price and our habitual high quality. Find out about the usefulness of this and our other guanylation reagents!

Canalin and Canavanine : New Fmoc building blocks for novel peptides and protein analogs

5-oxa-Derivatives of Orn and Arg, respectively, these rare amino acids are produced by legumes as protection against herbivores. For your convenience, we offer building blocks of both amino acids compatible with standard Fmoc/ t Bu SPPS chemistry

New Substituted Ornithine Derivatives

l -Ornithine derivative containing peptides play important roles in SAR studies, enzyme inhibition and cancer research. We now offer a variety of N δ -substituted ornithines containing heterocyclic, aromatic and aliphatic groups, as well as N- substituted C3- and C4-analogs of ornithine.

New: Guanidino-Glycine

Visit our Glycine section and find a series of amino acid derivatives, where oxazole is the characteristic structural element carrying carboxy and amino function.

NEW Hydrazone Resin

A new hydrazone resin enables a convenient way to synthesize peptide hydrazides for Hydrazone Ligation Technique and Native Chemical Ligation (NCL).

New: Cysteine-Pseudoproline

Pseudoprolines derived from Serine and Threonine have developed to standard building blocks for peptide synthesis since their invention. Now this technology is also available with Cysteine residues, as the corresponding 2,4-dimethoxyphenyl-pseudothiaproline is compatible with standard Fmoc/tBu protocols.

Improved Synthesis with Dmb-Glycine Dipeptide Building Blocks

Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.

Structural Element: Aminoisobutyric Acid and Homologues

Aminoisobutyric acid (Aib) and its homologues are a strong helix promoters in peptide mimetics. Aib-containing model peptides are already used in cancer treatment, antimicrobial peptides and cell penetrating peptides (CPP). We offer Aib and its homologues positioning the dimethyl fragment either close to the N- or to the C-terminus.

Bis-Boc-guanidinopyrazole

Arginine rich peptides show increased interest during the last years as they have the capability to cross cell and blood brain barrier membranes.

Aspartic and Glutamic Acid Homologues

Arginine rich peptides show increased interest during the last years as the have the capability to cross cell and blood brain barrier membranes.

Shorter Arginine homologues to stabilize peptides towards tryptic digestion

Abstract: Trypsin digests peptides at the position of arginine. Because shorter homologues of arginine with appropriate protecting groups for conventional Fmoc/tBu peptide synthesis are now available, three model peptides containing arginine and two shorter homologues of arginine were synthesized.