Search results for: 'Life'

HMPO (5-(hydroxymethyl)pyrogallol orthoester), a plasma-stable, pH-sensitive, 1,6-self-immolative crosslinker derived from the natural product gallic acid. Discover its properties!

You missed our Workshop with Prof. Thomas Carell? As unpublished data was shown, the recording of the workshop will just be available on our homepage in a few weeks. If you would like to be informed please get in contact via info@iris-biotech.de.

Where does life come from and how can we simulate early earth conditions leading to simple organic molecules such as nucleotides and amino acids, the building blocks of RNA and peptides?

What’s new? Don’t miss innovative building blocks and latest technologies – have a look at our new products flyer and discover our portfolio additions from January to June 2024!

Novel excipients can help you master the challenges associated with the production and formulation of protein- and RNA-based drugs due to their inherent fragility. Discover the SURPAX TM technology!

July 2-3, 2024

Level up! Carboxymethyl-modified amino acid building blocks suitable for incorporation by solid-phase peptide synthesis. Learn more about available derivatives and their properties.

You are looking for monodisperse Sarcosines ? You want to use Sarcosine for SPPS? You need to improve your drug's hydrophilicity and search for PEG alternatives? Read on!

Are you keen on developing novel billion-dollar-selling peptide API blockbusters? Most recent ones use lipophilic Albumin binding moieties. Of course, Iris Biotech has the necessary building blocks!

You missed our workshop featuring Dr. Quibria Guthrie (CEM Corporation)? Any further questions? Please get in contact via info@iris-biotech.de.

November 29-30, 2023

A heart of gold! Metals and ores - see here how their surfaces can be equipped with bifunctional organic linker molecules and thus be turned into modifiable biocompatible materials.

Bioengineering in combination with Linkerology® . Check out the unique options for membrane proteins, recombinant immunotoxins (RITs) and novel antibody-drug conjugates.

The potential of natural products of daily life , such as 6-shogaol from ginger ( Zingiber officinale) , can flourish if the active ingredient is conjugated to an appropriate carrier via Linkerology®. 

Curious about our latest portfolio additions from January to June 2023? Discover our New Products Flyer and check out the summary of recent product highlights! Get in contact for more details!

Plasma technology allows to equip inert polymers such as poly(ethylene) or polystyrene with functional groups like amine or carboxylate enabling further conjugations and applications. Read on!

Peptide therapeutics – fewer injections/lower doses by prolonging their half-life via addition of a lipid modification that promotes binding to serum proteins such as albumin. Read on for recent innovations!

From evolution to solution - natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.

Our monofunctionalized dextrans are enriching the toolbox of polymer therapeutics – Dextrans benefit of excellent solubility, biocompatibility, biodegradability, and non-immunogenicity.

Non-canonical Tryptophan analogs can help to improve your API’s performance in terms of potency, specificity, and stability. We offer various substituted Trp derivatives also available in small quantities for screening.

Herein, we present CliCr® as an innovative cyclic alkyne for metal-free strain-promoted click chemistry. Read our blog for detailed information about CliCr® reagents based on TMTHSI and check out available derivatives!

Curious about our latest portfolio additions from July to December 2022 and the 2022’s overall product and newsletter highlights? Click here to check out the summary or get in contact for more details!

No matter how much you hate them, in the pharmaceutical world you have to deal with them: Impurities. Iris Biotech can provide you with the molecules you require. Click here for more detailed information.

Iris Biotech is your trusted partner in the world of peptides and all related disciplines. Your project requires a compound not listed in our portfolio? Get in contact and inquire for a custom synthesis!

Iris Biotech offers the main building blocks for the synthesis of Liraglutide and Semaglutide and commonly observed impurities as well as reference standards. Read on for more information!

We are providing variously functionalized, protected and unprotected fatty acid derivatives suitable for SPPS and further conjugation, e.g. via Click chemistry. Read on to discover our portfolio.

Herein, we summarize certain product highlights and innovations, which we presented in our newsletters 2021. Have a look and get in contact for more information or an individualized offer.

Polysarcosines (PSars) – a true alternative to polyethyleneglycols (PEGs) - stand out in terms of safety, synthetic control, and versatility. Interested? Read on to find out more about their properties.

Selenocysteine (Sec) plays a crucial role for various biological processes, and selenoproteins can be found in all lineages of life. Read on to discover the 21 st amino acid, its derivatives and applications.

The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.

The incorporation of alpha-trifluoromethyl substituted amino acids into peptides increases proteolytic stability, enhances lipophilicity, and induces secondary structures. Read on to find out more!

Iris Biotech offers various (protected) azide- and alkyne-modified fatty acid derivatives suitable for Click Chemistry. Interested? Read on to find out more!

Interested in studying the effect of palmitoylation on your peptide’s localization, function, and stability? Read on to find out more about the use of lipidated “fatty” amino acids!

The highly lipophilic, bulky adamantyl motif is a promising and validated building block to increase the drug-qualities of lead compounds without increasing their toxicity.

January 19, 2021

Mpro is a key enzyme of coronaviruses (coronaviridae) and thus an attractive drug target. Iris Biotech offers fluorescent substrates, which can be used to perform various types of screenings and to identify potential inhibitors of COVID-19.

Iris Biotech offers various linked kinase inhibitors including analogues of Gefitinib, Imatinib, Sunitinib, Staurosporine and many more, which can easily be conjugated to other biomolecules, if desired. Have a look and read more.

We, Iris Biotech GmbH, are pleased that Dr. Thomas Bruckdorfer completes the BIOPARK8-Brain-Network in Regensburg and will enrich it with our experience.

Amongst various somatostatin analogues, the pentacyclic heptapeptide TT-232 bears unique properties. Iris Biotech offers TT-232 as triacetate and trifluoroacetate salt, respectively, as well as conjugated to either biotin or the fluorophore indocyanine green.

Alkyne amino acids allow for Click conjugations and other types of chemistry. Read more about alkyne-functionalized amino acids and our related products.

The tremendous success of Liraglutide and Semaglutide has moved amino acids modified with lipids into the focus of many research endeavors. Delve into the treasure trove of our lipidated amino acids!

The presence of phenyl groups in APIs is connected with various disadvantages. An increasingly popular solution is the use of BCP as a phenyl ring bioisostere. Find out more about this highly diversifiable motif.

Betulin and its derivatives are pentacyclic triterpenoids of the lupane-type. They are natural products that occur as secondary metabolites in over 200 different plants. Betulinic acid (BA) is a derivative of betulin that is oxidized at C-28.

12 - 15 November 2019

June 7-9, 2018 Aula Magna Partenope, Centro Congressi “Federico II” Naples, Italy

May 7-10, 2018

19 - 22 June 2017

Protein and lipid glycosilation is a life-governing and omnipresent process. Glycoconjugates display a multitude of biological effects from protein folding and stabilization, energy storage, cell surface interaction through molecular recognition motifs for cell-cell communication, and structural support and protection.

Polyamines such as ethylene diamine and its higher homologues are important feedstocks for the chemical industry. Compounds like putrescine, spermidine, and spermine play important roles in both eukaryotic and prokaryotic cells and show many other different biological functions.

Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.

PEGs show a spectrum of unique physical and chemical properties, which have been described in literature extensively by the pioneers in PEGylation: Harris, Veronese and recently by Hermanson. Here are summarized the most common known properties.

Amino protected amino-PEG-acids can be used for the PEGylation of solid particles in order to create hydrophilic and reactive surfaces with no non-specific binding issues.

Small drug molecules and also large biomolecules like proteins or antibodies suffer rapid clearance from human body.

Conjugates of PEG and folic acid or cholesterol, respectively, combine the positive properties of these molecules. Those conjugates are available with a wide variety of functional groups and different PEG chain lengths to suit your needs.

21-23 September 2016 Bangkok International Trade & Exhibition Centre (BITEC) 88th Bangna Trad Road, Bang Na, Bangkok 10260, Thailand

June 6th - 8th, 2016 Moscone Center - South hall San Francisco, CA, USA

April 18th-19th, 2016 London, UK Scientific discussions about the current results and future challenges of peptides research and therapeutics will be the main topic of this meeting.

Click chemistry is a convenient method to chemoselectively functionalize peptides at specific positions. We offer a variety of different propargyl amino acids for both Fmoc and Boc strategies, for enzymatic synthesis, as well as preloaded resins for SPPS.

5-oxa-Derivatives of Orn and Arg, respectively, these rare amino acids are produced by legumes as protection against herbivores. For your convenience, we offer building blocks of both amino acids compatible with standard Fmoc/ t Bu SPPS chemistry

October 7 to 9 2015 Melbourne, Victoria, Australia https://www.ausbiotech.org/ AusBiotech represents 3000 members covering the human health, agricultural, environmental, industrial, medical device, functional foods and Investment sectors in biotechnology. Over 150 events for the life science sector provide unique networking opportunities through business matching programs, sponsorship and guest speaker roles.

September 20th - 23rd, 2015 Center for Interdisciplinary Research (ZiF), Bielefeld University, Germany The Center for Biotechnology (CeBiTec) of Bielefeld University cordially invites you to attend the 5 th International Bielefeld-CeBiTec Research Conference on "Drug Conjugates in Directed Therapy” . CeBiTec Research Conferences are annual events with thematic focus on a challenging topic in the life sciences. The 2015 conference " Drug Conjugates for Directed Therapy " is being organize...

June 15th - 18th, 2015 Pennsylvania Convention Center Philadelphia, PA, USA The BIO 2015 covers the wide spectrum of life science innovations and application areas. Drug discovery, biomanufacturing, genomics, biofuels, nanotechnology and cell therapy are just a few of the industries represented at the BIO International Convention. The four key elements of the event are: BIO Education Program Networking Events BIO One-on-One Partnering TM   BIO Exhibtion

June 10th - 12th, 2015 Reitoria of Universidade Nova de Lisboa Campus de Campolide, Lisboa, Portugal The 6th European Conference on Chemistry for Life Sciences (6th ECCLS) will be held in Lisbon, Portugal, in June 10-12, 2015. Lisbon meeting will be sixth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009), Budapest (2011) and Barcelona (2013) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge between chemi...

  March 11th-12th, 2015 Technische Universität München Garching, Germany Latest findings and developments in the life sciences and their implementation in innovative technologies and new products in areas such as pharmaceutics, food and biotechnology will be at the focus of the 9th International Congress 'Forum Life Science' on 11-12 March 2015 at the Technische Universität Munich in Garching.

March 9th-11th, 2015 Porte de Versailles, Conference Center Expo Paris, France As the springtime counterpart to BIO-Europe, BIO-Europe Spring ® continues the tradition of providing life science companies with high caliber partnering opportunities. Featuring EBD Group’s acclaimed partnering system, partneringONE ® , the event enables delegates to efficiently identify, meet and get partnerships started with companies across the biotech value chain. In addition to productive part...

GABA is a neurotransmitter in the central nervous system of mammals and its deficiency is associated with severe neurological disorders. Statine, a GABA analogue, occurs in several peptide APIs. Derivatives of gamma-amino acid analogues are of continued vital interest for a variety of applications in medicinal chemistry. We have a tool box available to offer a broad range of substituted gamma-amino acids and statines on custom synthesis basis.

September 10th - 12th, 2014 LITEXPO, Vilnius Vilnius, Lithuania Life Sciences Baltics 2014 is the only international forum in the Baltics for world-class biotechnology, pharmaceutical and medical devices experts from all around the world. It provides a unique opportunity to explore the new horizons of partnerships, exchange ideas and seek progress through networking. Discover enormous potential and passion in the field of life sciences in Lithuania and the Baltics – the gateway to emerging market...

April 1st - 4th, 2014 Messe München Germany For four decades, analytica has been the leading international fair for state-of-the-art laboratory technology and pioneering biotechnology . No other trade fair in the world covers the range of subjects to do with the laboratory in industry and science in such breadth and depth, and on such a scale.

Compounds like putrescine, spermidine, and spermine play important roles in a many biological functions. Many of them are excellent targets for oncology studies and other fields of medicinal chemistry. Find in our new brochure Diamines & Polyamines our possibilities for custom synthesis and a set over 100 available derivatives.

Cfm Oskar Tropitzsch and Iris Biotech GmbH attended the China Hi-Tech-Fair (Nov 16-21, 2013) in Shenzhen. The Bavarian companies presented the latest stage of the art products in the field of peptides, life sciences research and drug discovery.

November 13th, 2013 Rudolf-Virchov-Zentrum Würzburg, Germany Iris Biotech GmbH nimmt am 6. Kooperationsforum Drug Developement - Targets-Design-Screening-  teil, wo über neuste Technologien und aktuelle Konzepte der Arzneimittelentwicklung zu informiert wird.

March 13-14th 2013 At the Technical University Munich, Germany

June 10th-12th, 2013 Auditorio AXA Barcelona, Spain Barcelona meeting will be fifth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009) and Budapest (2011) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge from chemistry to biology. 

Long-chain acylcarnitines are well-known intermediates in mitochondrial fatty acid oxidation

April 17th - 18th, 2012 Cambridge, UK The Peptide Conference will take place in conjunction with our new Dynamic Outsourcing for Life Sciences (DOLS) event, which will add extra value to your participation.

Forum Life Sciences 2011 Garching, Germany, Technical University Munich, 23 & 24 March, 2011 ( http://www.bayern-innovativ.de )

Dendrimers offer a new possibility to derivatize small molecules, surfaces or biopharmaceuticals with a monodisperse macromolecule and alter in this way properties like solubility and hydrophilicity. Immunogenicity and pharmacokinetics of pharmaceuticals will be improved. The synthetic approach for designing these dendrons of different generations is based on 2,2-bis(hydroxymethyl) propionic acid, which is a non-toxic and biocompatible building block. The size can be designed from 250 g/mole for 1st gene...

Peptides are key to modern drug discovery. This article reviews the requirements for bulk production of peptides and how it affects research and production of smaller scales.