Search results for: 'Piperazin'

Common Side Reactions in Fmoc Solid-Phase Peptide Synthesis

Collect information about the most common side reactions during Fmoc SPPS and how to avoid them! Choose your building blocks and conditions wisely to avoid unnecessary trouble!
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PotM: Cyclover-Amine for Peptide and Oligonucleotide Synthesis

Cyclophase Synthesis - Dissolve. React. Precipitate. Filter. Repeat! Make your peptide synthesis greener by avoiding DMF and benefit from the advantages of both liquid and solid phase synthesis.
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Protecting Groups in SPPS

Mix & Match. Discover typically employed protecting groups used to temporarily mask reactive functional moieties during solid-phase peptide synthesis to prevent undesired side-reactions.
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Amino-Li Resin – A Novel Solid Support

Shaken, not stirred. Amino-Li resin – a cross-linked polyacrylic amide solid support suitable for the synthesis of peptides and biomolecules, which is compatible with organic as well as aqueous solvents.
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Linkerology® for Targeted Delivery and Release

Use the possibilities of Linkerology® to boost the efficacy of your drug! We illustrate how the drug Gepirone (Exxua TM ), a medication to treat major depressive disorders, can be conjugated.
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Phenylisopropylester (OPP) as Carboxy Protecting Group

Explore phenylisopropylesters (OPP/OPis) as carboxy protecting groups. Facilitate your peptide synthesis with building blocks for precise side chain modifications or seamless macrolactamizations.
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PotM: Smoc Amino Acids

Herein, we present the Clean Peptide Technology using Smoc Amino Acids developed by Sulfotools in Germany. Replace organic solvents with water during peptide synthesis - Read on for more information!
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Workshop Prevention of Aspartimide Formation

You missed our workshop featuring Prof. Dr. Jeffrey W. Bode (ETH Zurich)? Any further questions? Please get in contact via info@iris-biotech.de
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4-Methylbenzhydryl-Resins - the Better Wang-Resin alternative

Wang resins are widely used for peptide synthesis. However, certain side reactions, like diketopiperazin formation limit their use. 4-Methylbenzhydryl resin needs more space and leaves less room for this type of side reactions. Standard “Wang-typical” Fmoc/tBu coupling protocols can be applied.
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Improved Synthesis with Dmb-Glycine Dipeptide Building Blocks

Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.
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