Search results for: 'amino peg'

HMPO: A pH-Responsive Linker for Targeted Drug Delivery

HMPO (5-(hydroxymethyl)pyrogallol orthoester), a plasma-stable, pH-sensitive, 1,6-self-immolative crosslinker derived from the natural product gallic acid. Discover its properties!

PotM: Versatile TentaGel® Resins

Discover the diversity of TentaGel® Resins ! Read our blog to get more information about our latest product additions and possible applications and find the right resin for your research endeavors!

Bioisosteric Argininine Analogs

Same but different! Expand your possibilities for peptide modification and fine-tuning by implementing N ω -carbamoylated arginine building blocks as bioisosteric arginine analogs.

Amino-Li Resin – A Novel Solid Support

Shaken, not stirred. Amino-Li resin – a cross-linked polyacrylic amide solid support suitable for the synthesis of peptides and biomolecules, which is compatible with organic as well as aqueous solvents.

Bifunctional TentaGel® Resins

Encode beads with unique tags for combinatorial syntheses & screening. Build libraries & identify hits. Discover properties and applications of our novel bifunctional TentaGel® resins.

Norbornenes – Will You Click Me?

Proposing norbornenes – strained, bicyclic alkenes for fast, copper-free, biocompatible click-conjugation with tetrazines. Read on for more details on applications and available products!

PotM: Oligomeric Sarcosine Building Blocks

You are looking for monodisperse Sarcosines ? You want to use Sarcosine for SPPS? You need to improve your drug's hydrophilicity and search for PEG alternatives? Read on!

Selective Lysine Labeling with Squaric Acid

Keeping control! PEGylating reagents with a squaric acid ethyl ester react chemoselectively with side chain amino functions of surface-accessible Lysines in proteins. Other functionalities are not affected.

Functionalization of Carbon Materials by Linker Attachment

Allotropes of carbon show distinct characteristics in structure and e.g. electric and biophysiological properties. Discover how these materials can be further exploited by linker attachment!

Review – Product Highlights 2023 (Part 1)

Curious about our latest portfolio additions from January to June 2023? Discover our New Products Flyer and check out the summary of recent product highlights! Get in contact for more details!

PotM: Limited Offer - Polysarcosine Bundles

From beginning of May until end of July 2023 we offer special polysarcosine bundles each containing three functionalized PSars of different molecular weight (5 kDa, 10 kDa, 15 kDa), 100 mg each.

PotM: Functionalized Dextrans

Our monofunctionalized dextrans are enriching the toolbox of polymer therapeutics – Dextrans benefit of excellent solubility, biocompatibility, biodegradability, and non-immunogenicity.

Amino-PEG-Acids

PEGs are being used as spacers, as hydrophilic decoration, and building blocks. Read on for more detailed information about the reactivity of different PEG derivatives and how to use them.

ChemMatrix® Discontinued

The ChemMatrix® resin production and distribution was discontinued by its manufacturer SEQENS. Products are only available at Iris till current stock is sold out. Read on for more information!

Workshop Polymer Therapeutics for Improved Drug Delivery

You missed our workshop featuring Prof. María Jesus Vicent Docón (Head of Polymer Therapeutics Lab)? Any further questions? Please get in contact via info@iris-biotech.de.

Drug Delivery at Iris Biotech

Discover our products suitable for drug delivery including poly ethyleneglycols (PEGs), poly amino acids (PArg, PGlu, PLys, POR, PSar), poly(oxazoline)s, as well as fullerenes. Read on to find out more!

Custom Synthesis Services at Iris Biotech

Iris Biotech is your trusted partner in the world of peptides and all related disciplines. Your project requires a compound not listed in our portfolio? Get in contact and inquire for a custom synthesis!

Interested in polymers for the delivery of promising drug candidates, e.g. nucleic acids? Discover our selection of lipidated polyamino acids and custom capabilities. Read on to find out more!

Sarcosine Building Blocks

Interested in the introduction of Sarcosine (N-methylglycine), e.g. for hydrophilicity increase of your derivative of choice or for PEG replacement? Check-out our available Sarcosine building blocks!

Building Blocks for the Introduction of Hydroxylamine

Herein, we present building blocks for the synthesis of protected hydroxylamine derivatives which can be further used for bio-conjugation and various other applications. Read on to find out more!

Special Offer – Summary Advent Calendar

See a summary of our advent calendar surprises and benefit from special discounts and great offers! Interested? Just click here to check-out all available products.

N-Methylation of Amino-PEG-Acids

Herein we are reporting on the linker stability of amino-PEG-acids achieved via N-methylation and the possible side-reaction without this additional modification. Read on to find out more!

PotM: Polysarcosines for Drug Delivery

Polysarcosines (PSars) – a true alternative to polyethyleneglycols (PEGs) - stand out in terms of safety, synthetic control, and versatility. Interested? Read on to find out more about their properties.

PotM: Functionalized Biotinylation Reagents

Iris Biotech offers a variety of (functionalized) biotin and desthiobiotin reagents reactive towards certain functional groups. Discover our growing portfolio and latest additions.

Enzymatically Cleavable Linkers Based on Val-Cit and Val-Ala

The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.

Arginine Derivatives Suitable for Side-Chain Derivatization

Herein we present two arginine derivatives, in which the native guanidino group is replaced by an isosteric amino-functionalized carbamoylated guanidino group that can serve as an attachment point for further derivatization.

(Functionalized) Fullerenes of Versatile Value

Iris Biotech presents (functionalized) fullerenes of different core size (C60 vs. C70) as versatile tools for multiple functionalization. Read more about their unique properties and fields of applications.

Product of the Month: Dde-based Linkers

Placing Dde as one terminal group of a linker and a functional group prone for conjugation as the other or using Dde as the central connective portion of a linker, allows for the creation of new bifunctional linkers.

Polyarginine

Polyarginines are well known for their ability to enhance cell penetration.

Poly(L-Glutamic Acid)

Poly-(α-L-glutamic acid) is a synthetic polypeptide of L-Glu linked by the alpha-amino groups (α-PGA). These polyanionic and biodegradable polymers can be used for a variety of purposes.

Polylysines

Polylysines are polymers of the canonical amino acid Lysine, and are characterized by their high charge density caused by the presence of one free amino group per lysine monomer.

Mercapto-PEG-Acids for Bioconjugation

Mercapto-PEG-Acids are highly hydrophilic, non-antigenic, non-immunogenic and non-toxic.

Recombinant Incorporation of Amino Acids into Proteins

Mutant or modified aminoacyl tRNA synthetases (aaRS) have been used to charge non-natural amino acids to the corresponding tRNA, which incorporates them into polypeptides or proteins during recombinant synthesis.

Specific Linkers

The variations for linkers are endless, as in our catalogue program already hundreds of different derivatives are available for conjugation of small molecules, biomolecules and surfaces to each other.

Comparison of Carriers for Polymer Therapeutics

The polymers in this context are a polymeric linear structures with n repeating units of monomers. Depending whether the polymer is consisting of one single molecular weight (only one n existing) or of a range of compounds with an average mass and a distribution of n around a mean value, polymers are referred to as “monodisperse” or “polydisperse”.

Poly(Glutamic Acid) as Versatile Biodegradable Drug Carrier

Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have already been used as building blocks in polymer drug conjugates and polymeric micelles.

Polysarcosine – a True Alternative to PEG

Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.

Poly(Ethylene Glycol) – the Pioneer in Polymer Therapeutics

PEGs show a spectrum of unique physical and chemical properties, which have been described in literature extensively by the pioneers in PEGylation: Harris, Veronese and recently by Hermanson. Here are summarized the most common known properties.

Amino-PEG-Acids and their Active Esters

Amino protected amino-PEG-acids can be used for the PEGylation of solid particles in order to create hydrophilic and reactive surfaces with no non-specific binding issues.

Polymers Enlarge the Potential of Biopharmaceuticals

The Biopharmaceuticals market, estimated at US$ 200 billion globally in 2013 by reportbuyer.com (Biopharmaceuticals - A Global Market Overview, 2013, London), is further projected to reach US$ 500 billion by 2020, growing at 13.5 % CAGR between 2010 and 2020.

Pharmacological Effects of Polymer Therapeutics

Small drug molecules and also large biomolecules like proteins or antibodies suffer rapid clearance from human body.

Photocleavable NCL-Auxiliary Glycine

This innovative auxiliary facilitates Native Chemical Ligation at the position of a Glycine residue in a peptide sequence. The auxiliary can be further functionalized, e.g. by PEGylation. Following NCL, the auxiliary is removed by irradiation with UV light.

Click Chemistry Tools: Propargyl Amino Acids

Click chemistry is a convenient method to chemoselectively functionalize peptides at specific positions. We offer a variety of different propargyl amino acids for both Fmoc and Boc strategies, for enzymatic synthesis, as well as preloaded resins for SPPS.

New: Guanidino-Glycine

Visit our Glycine section and find a series of amino acid derivatives, where oxazole is the characteristic structural element carrying carboxy and amino function.

Amino-PEG-Acids for Increased Solubilization.

For introducing amino-PEG-acids into a peptide chain, several affordable building blocks are available with all conventional protecting groups. They can be incorporated at any sequence position by standard coupling protocols.

The NEW Iris Biotech Catalogue is available now!

In the era of internet a printed edition of a catalogue still has some advantages and fans. You can make handwritten notes in your catalogue. The overview at each page inspires you to think about structure diversity or alternative strategies in terms of protecting groups, coupling reagents or immobilization. You quickly see what is commercially available and get fast an impression about approximate costs of your synthesis. Order now online >

Bis-Mal-Lysine

Bis Thiol & Amine reactive PEGylated Cross-Linker which has been used for enhanced receptor binding, for the design of long-acting conjugates for type 2 diabetes therapeutics and in reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators.

Phthalimidooxy PEG-based cross linkers

Phthalimidooxy PEG-based cross linkers form stable oximes with aldehydes, also latent ones as present in carbohydrates. Their reactivity is sufficiently mild for a broad used in creating conjugates with sensitive biologics.

Versatility of N3-AEEA, a short, monodiosperse Azido-PEG-carboxylic acid

The azido function can be used for different applications

Available Bulk

Our portfolio currently contains over 5500 products. Many of them – in particular standard consumables for peptide synthesis – are being produced in bulk quantities. Therefore we can keep our prices also for lab quantities at very competitive level. In case of need for bulk quantities please inquire: - All 20 Proteinogenic Fmoc-protected Amino Acids are available in 100+ kg Lots;

4-Azido-L-homoalanine

H-L-Aha-OH*HCl H-L-Dab(N3)-OH 4-Azido-L-homoalanine (S)-2-Amino-4-azidobutanoic acid hydrochloride Formula: C 4 H 8 N 4 O 2 *HCl Molecular Weight: 144,13*35,45 g/mole CAS: 942518-29-8 CODE: HAA5730 1g: EUR 200,- US$ 300,- 5g: ...