Search results for: 'ang'

Game Changer for Protein Modification: Discover oxidation-induced furan crosslinking and 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones ( 5HP2O s) as stable alternative to maleimides.

We expanded our portfolio of Fmoc-protected homo amino acids . Benefit of their unique properties to modulate the stability, hydrophobicity, and biological performance of your peptide!

HMPO (5-(hydroxymethyl)pyrogallol orthoester), a plasma-stable, pH-sensitive, 1,6-self-immolative crosslinker derived from the natural product gallic acid. Discover its properties!

Discover MYTsA as coupling reagent for peptide synthesis in “traditional” C→N and vice versa in “natural” N→C direction. Avoid racemization and benefit of improved atom economy!

Collect information about the most common side reactions during Fmoc SPPS and how to avoid them! Choose your building blocks and conditions wisely to avoid unnecessary trouble!

To address both chemical and IP considerations in self-immolating linker applications , we propose shifting from the commonly used Val-Cit-PAB linker to the less explored Gly-Gly-Phe-Gly-formyl motif.

Discover the diversity of TentaGel® Resins ! Read our blog to get more information about our latest product additions and possible applications and find the right resin for your research endeavors!

Where does life come from and how can we simulate early earth conditions leading to simple organic molecules such as nucleotides and amino acids, the building blocks of RNA and peptides?

Cyclophase Synthesis - Dissolve. React. Precipitate. Filter. Repeat! Make your peptide synthesis greener by avoiding DMF and benefit from the advantages of both liquid and solid phase synthesis.

Same but different! Expand your possibilities for peptide modification and fine-tuning by implementing N ω -carbamoylated arginine building blocks as bioisosteric arginine analogs.

Let’s make scientific progress together! To support especially young researchers, we now are granting a general discount of 5% on catalog items / quantities to universities and non-profit research institutions. 

What’s new? Don’t miss innovative building blocks and latest technologies – have a look at our new products flyer and discover our portfolio additions from January to June 2024!

Get the most out of your synthesis! Monitor your deprotection and coupling steps for completion and optimize your reaction protocols to maximize yields and minimize side-products! 

July 2-3, 2024

Encode beads with unique tags for combinatorial syntheses & screening. Build libraries & identify hits. Discover properties and applications of our novel bifunctional TentaGel® resins.

Wondering about the difference between Boc and Fmoc chemistry in solid phase peptide synthesis? Don't worry: in this short overview we will guide you through the basics of both strategies.

Use the possibilities of Linkerology® to boost the efficacy of your drug! We illustrate how the drug Gepirone (Exxua TM ), a medication to treat major depressive disorders, can be conjugated.

Proposing norbornenes – strained, bicyclic alkenes for fast, copper-free, biocompatible click-conjugation with tetrazines. Read on for more details on applications and available products!

June 10-12, 2024

Clever Move - Add positive effects to your molecule by introducing the most electronegative element. Discover fluorinated building blocks as game changer for your lead development. 

Level up! Carboxymethyl-modified amino acid building blocks suitable for incorporation by solid-phase peptide synthesis. Learn more about available derivatives and their properties.

Discover photocages – photosensitive protecting groups that are removed by irradiation with light of a defined wavelength, thus restoring the original, “active” state.

June 2-5, 2024

May 8th - 10th, 2024

Have an additional ace up your sleeve for selective and efficient peptide modification, cyclization, and/or bioconjugation. Explore 2-cyanopyridines for click-like reactions. Get more information!

Beyond cysteines: Unlock targeted side-chain modifications of your peptides and proteins via the introduction of 1,2-aminothiols and subsequent click-like functionalization. 

29 April - 1 May, 2024

Engineer shape-shifting peptides , controllable by a laser as magic wand! In this newsletter, we’ll explore the possibilities of photo switchable building blocks based on azobenzene.

You are looking for monodisperse Sarcosines ? You want to use Sarcosine for SPPS? You need to improve your drug's hydrophilicity and search for PEG alternatives? Read on!

April 22-23, 2024  

Boron is not boring at all! Today, we'll delve deeper into the exciting world of boronate-containing amino acid building blocks and unlock the potential of the next generation of peptides. Read on!

The targeted delivery and traceless release of drugs is an important concept in pharmacology. Discover the possibilities of payload conjugation to carrier proteins shown for the example drug Elacestrant.

Explore phenylisopropylesters (OPP/OPis) as carboxy protecting groups. Facilitate your peptide synthesis with building blocks for precise side chain modifications or seamless macrolactamizations. 

You are looking for a building block suitable to control the folding characteristics of your peptide or want to add a pH-sensitive conformational switch? Discover aminoprolines and their properties!

March 18-20, 2024

Live-imaging of dynamic structures and catching events in living cells is a challenge, as most fluorescent probes have a high background signal. For alternatives, please read on!

Are you keen on developing novel billion-dollar-selling peptide API blockbusters? Most recent ones use lipophilic Albumin binding moieties. Of course, Iris Biotech has the necessary building blocks!

The tetrazole isostere of malonyllysine is thermally stable and does not suffer from decarboxylation. Discover our building blocks suitable for incorporation via solid-phase peptide synthesis.

REACH regulation for the handling of N , N -dimethylformamide (DMF), the most commonly used solvent for solid-phase peptide synthesis (SPPS). Read more about consequences and alternatives!

Increase your peptide’s stability, introduce an NMR label for analysis, or enhance lipophilicity. Read our blog to discover our latest toolbox additions in the field of non-canonical amino acids.

January 28 - February 1, 2024

The festive season already started and with it, the year is drawing to a close. We would like to thank you for your trust and the pleasant cooperation in 2023.

Discover possibilities to fight chronic pain diseases by employing linker technologies. Check out the options for multiple drug conjugation in combination with different release mechanisms.

Add glycans to your proteins with our ready-to-use Fmoc asparagine building blocks suitable for solid phase peptide synthesis and produce peptides with exactly defined glycosylation patterns!

December 5, 2023

The discovery of the Merrifield peptide synthesis paved the way for automated solid-phase peptide synthesis (SPPS) enabling fast and convenient simultaneous peptide synthesis.

Discover our small-sized, neutral Fmoc-protected nitrobenzoselenadiazole- and nitrobenzothiadiazole-modified amino acids suitable for SPPS of fluorescent peptides. 

One molecule, two identities: PNAs are composed of nucleobases arranged on a peptidic backbone. Discover our PNA building blocks as ready-to-use bases suitable for SPPS.

November 29-30, 2023

November 27-29, 2023

A heart of gold! Metals and ores - see here how their surfaces can be equipped with bifunctional organic linker molecules and thus be turned into modifiable biocompatible materials.

Ongoing research efforts lead to the discovery of innovative building blocks and new APIs. However, for industrial applications, upscaling is required. Herein, we share the process development for Fmoc-Cys(Msbh)-OH.

Keeping control! PEGylating reagents with a squaric acid ethyl ester react chemoselectively with side chain amino functions of surface-accessible Lysines in proteins. Other functionalities are not affected.

October 24-26, 2023

October 26-28, 2023

Discover our new building block 4-(azido-propyl-tetrazine)phenylalanine (pTAF) and make use of the orthogonality of the 2 nd and 3 rd generation Click reaction to build multiconjugates via double-Click.

October 15-20, 2023

October 10 - 13, 2023

September 17 - 21, 2023

TCEP is an effective reductant for disulfide bonds and a versatile reagent for various applications in protein science with distinct advantages compared to DTT and BME.

The potential of natural products of daily life , such as 6-shogaol from ginger ( Zingiber officinale) , can flourish if the active ingredient is conjugated to an appropriate carrier via Linkerology®. 

September 6-8, 2023

September 4 - 5, 2023

August 28 - 30, 2023

Allotropes of carbon show distinct characteristics in structure and e.g. electric and biophysiological properties. Discover how these materials can be further exploited by linker attachment!

Discover the cyanobenzothiazole (CBT) click reaction , a not (yet) so well-known biocompatible and bio-orthogonal mechanism faster than the famous azide-alkyne cycloaddition (CuAAC).

Add a new dimension of orthogonality to your peptide synthesis by using Safety-Catch arylalkyl sulfoxide protecting groups! This newsletter tells you about benefits and usage – Read on!

Discover our diazirine-substituted building blocks suitable for the analysis of protein-protein and RNA-protein interactions via proximity labeling upon photoactivation. Read on for more information!

Plasma technology allows to equip inert polymers such as poly(ethylene) or polystyrene with functional groups like amine or carboxylate enabling further conjugations and applications. Read on!

You missed our workshop featuring Prof. Rob Liskamp (Cristal Therapeutics, University of Maastricht, University of Glasgow)? Any further questions? Please get in contact via info@iris-biotech.de.

June 24th - 29th

Our building block Fmoc-L-Cys(Cam)-OH enables peptides resembling reduced and carbamido-methylated protein fragments by standard SPPS without error-prone modification reactions.

Shine bright like our fluorophores! Learn how our superior fluorogenic protease substrate peptides can enhance your test performance. Click here to gather more information and discover available products!

Infinite like the deep sea – marine natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.

June 5th - 8th

Building blocks with a strained triple bond do not require copper catalysis when used in click chemistry. Discover CliCr®: improved solubility in aqueous conditions and high reactivity! Click here!

Peptide therapeutics – fewer injections/lower doses by prolonging their half-life via addition of a lipid modification that promotes binding to serum proteins such as albumin. Read on for recent innovations!

From beginning of May until end of July 2023 we offer special polysarcosine bundles each containing three functionalized PSars of different molecular weight (5 kDa, 10 kDa, 15 kDa), 100 mg each.

May 10th - 12th

April 26th - 28th

From evolution to solution - natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.

Our monofunctionalized dextrans are enriching the toolbox of polymer therapeutics – Dextrans benefit of excellent solubility, biocompatibility, biodegradability, and non-immunogenicity.

April 21st

Non-canonical Tryptophan analogs can help to improve your API’s performance in terms of potency, specificity, and stability. We offer various substituted Trp derivatives also available in small quantities for screening.

Coupling Reagents are required for the formation of an amide or ester bond. As simple as those reactions seem to be, the choice of the appropriate reagent is crucial for optimizing purity and yield.

You missed our workshop featuring Prof. Christian F. W. Becker (University of Vienna)? Any further questions? Please get in contact via info@iris-biotech.de.

Maleimides provide versatile options for connecting payloads to proteins and other biomolecules. Discover how our bifunctional thiol reactive crosslinkers can support your project. Read on!

Herein, we present functionalized perfluorobiphenyl building blocks which can be used for site-selective π -clamp mediated cysteine conjugation. Read on for more details about this general method!

March 20th - 22nd, 2023

March 9th - 12th, 2023

Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!

February 28th - March 2nd

February 23nd - 25th

The HaloTag®, SNAP-Tag® and CLIP-Tag TM represent versatile tools for the specific, covalent attachment of in principle any molecule of choice to a protein of interest. Discover our substrates!

(Bi)functional dioxoborolane and disulfide-based self-immolative linkers – mode of action and application examples for the detection of H 2 O 2 , for prodrug design, and reversible peptide cyclization.

You want to get an overview about the different Click technologies as well as available derivatives and applications? Let’s arrange a (virtual) talk by Iris Biotech about your topic of choice – Contact us!

In two joint studies together with Prof. F. Albericio we investigated the coupling efficiencies of Ser and Thr pseudoproline monomers and their use for the synthesis of inaccessible peptide sequenes. Read on!

Curious about our latest portfolio additions from July to December 2022 and the 2022’s overall product and newsletter highlights? Click here to check out the summary or get in contact for more details!

We can’t get enough of new products and innovations! Read this blog to get detailed information on the cyanylating reagent NTCB as well as selenocysteine amino acids, both useful tools for peptide ligation.

Jensen et al. developed two methods that use poly-His sequences to direct the highly selective acylation of proteins, either at the N-terminus or at a specific Lys residue. Read on for more information.

See how our “mRNA grade” DTT and Spermidine can support also your nucleic acid production. Read on for more information.

Linkers serve as versatile tools, e.g. during SPPS or for the sophisticated (self-immolative) conjugation of a potent small molecule to a carrier. Check out our selection of over 100 readily available linkers.

The 2022 Chemistry Nobel prize is awarded to B. Sharpless, M. Meldal and C. Bertozzi for their work in the field of Click Chemistry. At Iris, we are providing clickable building blocks for nobel chemistry. Read on for more information!

The ChemMatrix® resin production and distribution was discontinued by its manufacturer SEQENS. Products are only available at Iris till current stock is sold out. Read on for more information!

November 1st - 3rd

October 11th - 14th

You are working on complex peptides and are looking for a new level of orthogonality facilitating the overall synthetic process and improving your yields? Check out the Msbh safety-catch protecting group!

From mg synthesis of a peptide up to bulk quantities often makes a huge difference in the route of production. Read on for more information about Iris Biotech’s process development services.

1,4-Benzenedimethanethiol is used as thiol scavenger during solid-phase peptide synthesis. In comparison to other thiol scavengers, this reagent is odorless and provides high quality crude peptides.

As the molecular diversity of cyclic and branched peptides becomes more and more challenging, a high level of orthogonal dimensionality is required. Herein, we present a new category of orthogonal protecting groups.

Herein, we report the first-time SPPS of a special peptide sequence via employment of of a serine pseudoproline building block as well as sec-isamyl mercaptan (SIT) as cysteine protecting group.

Herein, we present the Clean Peptide Technology using Smoc Amino Acids developed by Sulfotools in Germany. Replace organic solvents with water during peptide synthesis - Read on for more information!

August 28 th - September 2 nd 2022

August 25 th - 26 th 2022

You want to get an overview about the various resins available at Iris Biotech as well as their specifications, differences, and applications? Read on for further information and details.

You just started working in the field of solid phase (peptide) synthesis and want to get familiar with resins? Click here to get an overview about the different parameters describing resins.

We are highly excited to see the research that our products are used for. Send your peer-reviewed scientific publication to publication@iris-biotech.de for citation – we will reward you.

The Dawson Linker and its variants provide access to C-terminal peptide thioesters which are crucial components of Native Chemical Ligation reactions. Read on to discover all derivatives available at Iris Biotech!

Are you active in the field of antibody drug conjugates? Click here to find out more about our selection of as well as the technology behind pH-sensitive self-immolative linkers.

The para -azido benzyloxycarbonyl protected lysine building block Fmoc-L-Lys(4-N3-Z)-OH (FAA8830) is useful for a wide range of applications. Read on to find out more!

Photoswitches grant the ability to modulate the function of a molecule by effecting a structural change upon irradiation with UV light. Find out about our photoswitchable building blocks and their properties.

Dyes and fluorescent labels are an invaluable tool for diagnostics, medical and biochemical research. Iris Biotech offers labels with excitation ranges from UV to near-IR and various functional groups.

For selected products we added minimum purity and minimum enantiomeric purity as part of our product description on our website. High product qualities at Iris Biotech – Read on for more info.

Discover our products suitable for drug delivery including poly ethyleneglycols (PEGs), poly amino acids (PArg, PGlu, PLys, POR, PSar), poly(oxazoline)s, as well as fullerenes. Read on to find out more!

Drug the undruggable – click here to get more information about the use of PROteolysis TArgeting Chimeras (PROTACs®) as a tool for targeted protein degradation and discover available building blocks.

Iris Biotech offers the main building blocks for the synthesis of Liraglutide and Semaglutide and commonly observed impurities as well as reference standards. Read on for more information!

We are providing variously functionalized, protected and unprotected fatty acid derivatives suitable for SPPS and further conjugation, e.g. via Click chemistry. Read on to discover our portfolio.

Oxidation is not only a known degradation pathway of proteins and peptides in vivo but is also a major side reaction for certain amino acids during peptide synthesis in vitro. Read on to discover our available building blocks.

Discover our selection of disulfide-based self-immolative linkers allowing to influence linker stability, fine-tune the self-immolative cleavage rate and thus impact the speed of the payload release.

Interested in polymers for the delivery of promising drug candidates, e.g. nucleic acids? Discover our selection of lipidated polyamino acids and custom capabilities. Read on to find out more!

Interested in the introduction of Sarcosine (N-methylglycine), e.g. for hydrophilicity increase of your derivative of choice or for PEG replacement? Check-out our available Sarcosine building blocks!

Discover our selection of propargyl-substituted amino acids and find the best position for subsequent Click chemistry within your peptide/protein. Just click here for further information on our products.

Looking for an acid stable protecting group? Struggling with undesired loss of the Cbz protecting group while removing Boc under acidic conditions? Read on to find out more about iNoc as alternative.

Stable isotopically labeled drugs are routinely used to investigate a drug’s metabolism, distribution, bioavailability, side effects and potential toxicity. Discover our selection of labeled drugs.

Discover our selection of substrates for Halo-, Snap-, and Clip-tagged proteins bearing different terminal groups suitable for further functionalization, e.g. biotinylation and Click chemistry.

Herein, we summarize certain product highlights and innovations, which we presented in our newsletters 2021. Have a look and get in contact for more information or an individualized offer.

Herein we present a series of alpha,alpha-cycle-disubstituted amino acid derivatives used in peptide design for their structure promoting effects as well as conformational rigidity.

Herein we are reporting on the linker stability of amino-PEG-acids achieved via N-methylation and the possible side-reaction without this additional modification. Read on to find out more!

Polysarcosines (PSars) – a true alternative to polyethyleneglycols (PEGs) - stand out in terms of safety, synthetic control, and versatility. Interested? Read on to find out more about their properties.

Back in the lab after enjoying your holidays? Motivated to run new experiments but lacking certain building blocks or standards? Check out our huge portfolio or get in contact for our special offers!

Discover the versatile applications of hydrazone resins e.g. for the preparation of peptide hydrazides, or the generation of peptide thio esters. Read on to find out more and see our available products.

Selenocysteine (Sec) plays a crucial role for various biological processes, and selenoproteins can be found in all lineages of life. Read on to discover the 21 st amino acid, its derivatives and applications.

Read on for more information about the right handling of Maillard Reaction Products (MRPs), which are frequently used as analytical standards related to food quality and disease processes.

Herein we are presenting 2-(Fmoc-amino)-3,3-diMe-pent-4-enoic acid (FAA5040), a protease stable Ile/Leu surrogate suitable for further modification via its side chain double bond.

Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.

Iris Biotech offers a variety of (functionalized) biotin and desthiobiotin reagents reactive towards certain functional groups. Discover our growing portfolio and latest additions.

Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which can be elongated by Fmoc-SPPS and can easily be linked to amino-functionalized solid supports. Read on to find out more about their advantages.

Compounds of the shown formula can simply be bound to solid supports via amide bond formation without racemization of the C-terminal amino acid and enable the synthesis of very pure peptides.

The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.

Interested in structure-activity studies of your Proline-containing peptide drug? Find out more about the use of Methanoprolines and Dimethylprolines as conformational amide locks.

Read on to find out more about Iris Biotech’s Linkerology® portfolio including substituted pyridyldithiols as building blocks for the reversible chemical conjugation to sulfhydryls.

Interested in studying the effect of palmitoylation on your peptide’s localization, function, and stability? Read on to find out more about the use of lipidated “fatty” amino acids!

Interested in structure activity studies on your Arginine containing peptide or further optimization for improved receptor binding? Explore our guanidino Proline derivatives as rigid Arginine mimics.

Are you using the Fmoc-MeDbz-OH Dawson Linker in large scale on a regular basis? A robust and economic processallows us to promptly provide you with kg quantities at competitive prices and in high quality.

Herein we present substituted diazacyclononynes (DACNs) as versatile tools for metal-free strain-promoted Click Chemistry that are characterized by high reactivity and stability, both thermally and chemically.

The highly lipophilic, bulky adamantyl motif is a promising and validated building block to increase the drug-qualities of lead compounds without increasing their toxicity.

Herein, we present aminooxy-amino acids reported for peptide synthesis via oxime ligation, cyclization via oxime formation, derivatization e.g. by glycosylation, or chelation. Read on to find out more.

Herein we present two arginine derivatives, in which the native guanidino group is replaced by an isosteric amino-functionalized carbamoylated guanidino group that can serve as an attachment point for further derivatization.

Cyclopropanes represent important design elements in medicinal chemistry and are widely present in drug compounds. Read on to find out more about their full potential.

The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.

Interested in the formation of peptide thioesters for Native Chemical Ligation? Read on to find out more about the use of Dawson Linker derivatives as thioester surrogates compatible with Fmoc SPPS.

The thiosuccinimide linkage is a prominent connective motif resulting from the reaction of a thiol and an alkyl maleimide. Read on to learn more about its applications and potential improvements.

Mpro is a key enzyme of coronaviruses (coronaviridae) and thus an attractive drug target. Iris Biotech offers fluorescent substrates, which can be used to perform various types of screenings and to identify potential inhibitors of COVID-19.

Interested in histidine derivatives? Iris Biotech provides a selection of deamino- and decarboxy-products. Find out more about benefits and potential applications of our new building blocks.

Fighting COVID-19 by modifying essential viral proteins via glycation through methylglyoxal – a reactive carbonyl compound known from the Maillard reaction. Read on to find out more!

Iris Biotech offers various linked kinase inhibitors including analogues of Gefitinib, Imatinib, Sunitinib, Staurosporine and many more, which can easily be conjugated to other biomolecules, if desired. Have a look and read more.

Iris Biotech presents its selection of Val-Cit-based linkers, a dipeptide motif frequently utilized for the development of ADCs with increased serum stability and high cleavage efficiency.

Iris Biotech presents (functionalized) fullerenes of different core size (C60 vs. C70) as versatile tools for multiple functionalization. Read more about their unique properties and fields of applications.

Iris Biotech presents the next-generation of hydrolysis-stable phosphono-analogs of pSer, pThr and pTyr. Fluorination renders the phosphonic acid more acidic and thus an even better mimic of the parent phosphoamino acid.

Looking to optimize or functionalize your peptide? Explore our ever-growing selection of Arg derivatives and find the one suitable for your application.

Isopropyl-β-D-thiogalactopyranoside (IPTG) is one of the most commonly utilized reagents in molecular biology.

Find out more about those building blocks with side chains able to coordinate metal ions, and why peptide-based HDACis are intriguing synthetic targets.

Learn, how His-Tag can be used for specific linker attachment. Another example in our LINKEROLOGY series of sophisticated linker technologies.

Amongst various somatostatin analogues, the pentacyclic heptapeptide TT-232 bears unique properties. Iris Biotech offers TT-232 as triacetate and trifluoroacetate salt, respectively, as well as conjugated to either biotin or the fluorophore indocyanine green.

Find out which Maillard Reaction Products from Iris Biotech were used in the development of a state-of-the-art analytical method for 15 different AGEs.

Placing Dde as one terminal group of a linker and a functional group prone for conjugation as the other or using Dde as the central connective portion of a linker, allows for the creation of new bifunctional linkers.

The ever-growing sophistication and variation in linker design have given rise to a new and distinct field of knowledge in synthetic chemistry termed Linkerology. Discover our expertise and panoply of new cutting-edge tailor-made linker constructs for the latest state-of-the-art bioconjugations.

Alkyne amino acids allow for Click conjugations and other types of chemistry. Read more about alkyne-functionalized amino acids and our related products.

The integrin receptor interacting RGD sequence and related peptides act as promising tools for drug therapy and cancer research. Find more information on our portfolio of cyclic RGD peptides.

DTT is a powerful yet mild reducing agent. Based on your demand we can offer different quality grades to suit your needs.

Sidechain-derivatized amino acids have shown great potential in enhancing select properties of peptide lead compounds. Find the most recent additions to our portfolio of amino acids bearing additional aryl and alkyl groups in their side chains.

Peptide purification after SPPS usually requires time- and solvent-consuming HPLC, which is often limited by co-eluting side-products. Belyntic’s catch-and-release PEC-Linker chemoselectively catches the desired product from your crude to reach a new dimension of purity.

The tremendous success of Liraglutide and Semaglutide has moved amino acids modified with lipids into the focus of many research endeavors. Delve into the treasure trove of our lipidated amino acids!

The presence of phenyl groups in APIs is connected with various disadvantages. An increasingly popular solution is the use of BCP as a phenyl ring bioisostere. Find out more about this highly diversifiable motif.

Our distribution partner in Mumbai / India, Sumit Biosciences Pvt Ltd., recently opened a new warehouse in Mumbai to stock various Iris Biotech products from our amino acids and resins product ranges. Stocked pack sizes range from 5 g to 1 kg.

Betulin and its derivatives are pentacyclic triterpenoids of the lupane-type. They are natural products that occur as secondary metabolites in over 200 different plants. Betulinic acid (BA) is a derivative of betulin that is oxidized at C-28.

Biotinylation of proteins and their purification via Streptavidin beads is a widely applied method.

Proximity labeling of proteins with biotin-phenol (biotin-tyramide) and an engineered peroxidase enzyme (e.g. APEX = Engineered Ascorbate Peroxidase) is a pivotal tool for molecular biology.

21 - 22 October 2019

Two selected publications were summarized in this article in order to highlight the impressive utility of amino acids incorporating the diazirine photophore.

9 - 11 October 2019

5 - 7 September 2019

22 - 27 June 2019

3 - 7 December 2018

o -Nitroveratryloxycarbonyl (Nvoc) is a photocleavable side chain protecting group for lysine that can be removed by irradiation with UV light (350 nm).

Succinylation of proteins on the epsilon-amino group of lysine residues is a posttranslational modification that is still poorly understood.

Delivery of hydrophilic compounds across membranes is usually problematic. Modification with triphenylphosphonium ions has been shown to overcome this barrier.

Indocyanine Green (ICG) dye, a material approved by the FDA for various applications, is a powerful tool for imaging in live cells and tissues .

Phosphorylation of serine, threonine and tyrosine is counted among the most important posttranslational modifications that occur in organisms.

Iris Biotech introduces a comprehensive set of photo-crosslinking amino acids bearing the diazirine moiety.

The use of bioactive peptides has increased over the recent years as they attracted attention for their use as therapeutic agents.

Of course, Iris Biotech is aiming to deliver your products as fast as possible. The following table provides an overview of general delivery times for products which are on stock and are not counted as dangerous goods. Stock Items Delivery Destination Germany Europe Worldwide Delivery Time 1 Day 1-2 Days Around 2-5 Days Although smaller quantities of dangerous goods can often be delivered just as fast as substances that are not declare...

Iris Biotech is working with qualified and reliable logistic partners. As various factors are influencing freight costs, the following information is only to be understood as approximate values. ≤ 1kg* Delivery Destination Germany Europe Worldwide Costs 20,00 EUR 25,00 EUR Please inquire Delivery Time 1 Day 1-2 Days Around 2-5 Days * Dangerous goods excluded. Prices are subject to changes. > 1kg* ...

Polyarginines are well known for their ability to enhance cell penetration.

This alkyne-functionalized cysteine building block can be incorporated into peptides via the Fmoc strategy.

In accordance with EU Regulation No. 1907/2006, Iris Biotech GmbH is providing safety data sheets (SDS) for several products in various languages as free download. Please directly download the respective safety data sheet on the corresponding product page. If not available, please contact us directly: Tel: +49 (0) 9231 97121-0 Fax: +49 (0) 9231 97121-99 Email: info@iris-biotech.de

The Fmoc group is the most frequently used protecting group in peptide chemistry. The most common deprotection conditions involve a solution of 20% piperidine in DMF.

Poly-(α-L-glutamic acid) is a synthetic polypeptide of L-Glu linked by the alpha-amino groups (α-PGA). These polyanionic and biodegradable polymers can be used for a variety of purposes.

Amino acids of high quality are crucial for the synthesis of peptides with a high purity.

Polylysines are polymers of the canonical amino acid Lysine, and are characterized by their high charge density caused by the presence of one free amino group per lysine monomer.

10 - 11 August 2017

5 - 7 July 2017

17 - 22 June 2017

20 - 23/03/2017

Mercapto-PEG-Acids are highly hydrophilic, non-antigenic, non-immunogenic and non-toxic.

Azido and alkyne functions can cyclise by an intramolecular CuI or Cu0 catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC). This so-called Click Reaction, developed by K. Barry Sharpless and Morton Meldal, has meanwhile grown to a widely used type of reaction orthogonal to many other types of reactions in different kinds of applications.

a) Catalyst-free Click Reaction Cycloaddition reactions such as the [3+2] azide-alkyne and the [4+2] Diels-Alder reaction, are becoming common conjugation techniques. Applications range from imaging, drug design and development of sensors, thereby spanning the fields of chemical biology, material science, surface and polymer chemistry as well as many other fields. Introduced in 2002, the copper-catalyzed variant of the azide-alkyne cycloaddition (CuAAC) reaction has found broad applicability in t...

Mutant or modified aminoacyl tRNA synthetases (aaRS) have been used to charge non-natural amino acids to the corresponding tRNA, which incorporates them into polypeptides or proteins during recombinant synthesis.

The azido group can be reduced to an amino function and hereby serve as masked amino group. It is of particular use if additional orthogonalities are needed. Azido is stable towards treatment with piperidine (Fmoc deprotection), Pd(0) (Alloc removal) and acidic treatmet (cleavage of Mtt, Trt or other acid sensitive groups). However, as it is a pseudohalogenide, care has to be taken during coupling steps, as HATU will cause high racemization. This can be avoided using collidine or other non-nucleophilic bas...

Protein and lipid glycosilation is a life-governing and omnipresent process. Glycoconjugates display a multitude of biological effects from protein folding and stabilization, energy storage, cell surface interaction through molecular recognition motifs for cell-cell communication, and structural support and protection.

Click Chemistry in DNA Synthesis - Applications and Procedures in DNA Synthesis

α-Methyl and alkyl-amino acids can be produced by a number of platforms, where the (2S,4S)-4-methyl-2-phenyloxazolidin-5-one scaffold is one of the most popular one.

The polymers in this context are a polymeric linear structures with n repeating units of monomers. Depending whether the polymer is consisting of one single molecular weight (only one n existing) or of a range of compounds with an average mass and a distribution of n around a mean value, polymers are referred to as “monodisperse” or “polydisperse”.

The polymers in this context are a polymeric linear structures with n repeating units of monomers. Depending whether the polymer is consisting of one single molecular weight (only one n existing) or of a range of compounds with an average mass and a distribution of n around a mean value, polymers are referred to as “monodisperse” or “polydisperse”.

Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have already been used as building blocks in polymer drug conjugates and polymeric micelles.

Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.

PEGs show a spectrum of unique physical and chemical properties, which have been described in literature extensively by the pioneers in PEGylation: Harris, Veronese and recently by Hermanson. Here are summarized the most common known properties.

Nanotechnology and nanobiotechnology using gold or silver particles, quantum dots or even magnetic particles are broadly diverse, rapidly expanding areas of study in medical diagnostics and therapeutics, sensoric and chemistry.

The Biopharmaceuticals market, estimated at US$ 200 billion globally in 2013 by reportbuyer.com (Biopharmaceuticals - A Global Market Overview, 2013, London), is further projected to reach US$ 500 billion by 2020, growing at 13.5 % CAGR between 2010 and 2020.

Small drug molecules and also large biomolecules like proteins or antibodies suffer rapid clearance from human body.

Abstract: A symposium report. Protected peptides were synthesized using 9-fluorenylmethoxycarbonyl (Fmoc) amino acids and the acid labile 2-chlorotrityl and the multidetachable 2-chlorotrityl-Rink-linker resins.

We now offer a series of Lysine dendrons for chemoselective functionalization of molecules containing carbonyl groups. These multivalent molecules carry diverse types of moieties, such as amine- or hydroxyl-groups, DOTA chelators or triphenylphosphonium (TPP) cations.

Conjugates of PEG and folic acid or cholesterol, respectively, combine the positive properties of these molecules. Those conjugates are available with a wide variety of functional groups and different PEG chain lengths to suit your needs.

10-13 October 2016 San Diego, CA, USA Marriot Marquis & Marina

21-23 September 2016 Bangkok International Trade & Exhibition Centre (BITEC) 88th Bangna Trad Road, Bang Na, Bangkok 10260, Thailand

This innovative auxiliary facilitates Native Chemical Ligation at the position of a Glycine residue in a peptide sequence. The auxiliary can be further functionalized, e.g. by PEGylation. Following NCL, the auxiliary is removed by irradiation with UV light.

The classic FRET pair EDANS and DABCYL is now available linked to Fmoc amino acid building blocks that can be readily used in SPPS. Conveniently synthesize your own custom protease substrates!

Omniligase-1 enables efficient and racemization-free ligation of two side-chain unprotected peptide fragments at many different positions. Test this innovative enzyme developed by EnzyPep B.V. using the complementary model peptides included in our kit!

Peptides as pharmaceutical compounds suffer from unfavorable pharmacokinetics which is, among other things, due to a slow uptake into cells and rapid proteolytic cleavage. N -Alkylation of peptides is a valuable tool to overcome these limitations. We now offer new kits that enable the facile preparation of peptoids and N -alkylated peptides.

The regioselective formation of multiple disulfide bonds is often a synthetic challenge. We now offer an innovative safety-catch Cys protecting group that allows selective deprotection of the sulfhydryl group and is a valuable addition to the peptide chemist’s toolbox.

May 26th-27th, 2016 Lille, France The third Chemical Ligation Meeting is a one-day international meeting focused on ligation chemistry broadly defined. The meeting will cover a large range of topics from synthetic methodology applied to peptides, proteins, polysaccharides or nucleic acids to applications in medicine and materials.  Read more online

The reaction between a tetrazine (Tz) and a trans -cyclooctene (TCO) is the innovative third generation Click reaction that proceeds without the use of copper or other catalyst. It is rapid, fully bioorthogonal and excels at very low concentrations.

Asymmetric Rhodamine 110 protease substrates are used for the determination of protease kinetics. The asymmetric structure of these dyes greatly simplifies the determination of enzyme kinetics, while the properties of Rhodamine 110 facilitate an uncomplicated readout.

Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.

Maillard Reaction Products (MRPs) result from the reaction of Arg and Lys side chains with reducing carbohydrates. MRPs are valuable markers for food quality and are used in many different branches of industry such as food, pharma, cosmetics and biochemistry.

2-Furyl-alanine can be incorporated into peptides via SPPS or by using enzymatic approaches. UV-irradiation in the presence of oxygen and a photosensitizer converts furyl-alanine to an intermediate that selectively reacts with certain nucleophiles. This property can be employed for site-specific labeling of peptides and proteins.

Our new Biotin-SS-Tyramide linker is a valuable tool for peroxidase-promoted targeted protein biotinylation. By using peroxidase-tagged antibodies, proteins and protein clusters can be selectively biotinylated, and then isolated using streptavidin. The biotin tag can be subsequently removed using reducing agents (e.g. glutathione).

Click chemistry is a convenient method to chemoselectively functionalize peptides at specific positions. We offer a variety of different propargyl amino acids for both Fmoc and Boc strategies, for enzymatic synthesis, as well as preloaded resins for SPPS.

5-oxa-Derivatives of Orn and Arg, respectively, these rare amino acids are produced by legumes as protection against herbivores. For your convenience, we offer building blocks of both amino acids compatible with standard Fmoc/ t Bu SPPS chemistry

Peptide linkers usually are cleaved under acidic conditions or using two-step procedures. Photocleavage proceeds under neutral conditions using UV light and can either be performed in batch or using flow chemistry.

October 22 to 25, 2015 Ramada Couran Cove Island Resort, South Stradbroke Island, Queensland, Australia http://solidphase.org The symposium provides a superb opportunity for all practitioners of solid phase peptide synthesis together with those who use synthetic peptides for a myriad of applications to congregate at the beautiful Couran Cove Resort, South Stradbroke Island, a short ferry ride from the famed Gold Coast of Queensland .

October 13th - 15th, 2015 Feria de Madrid, Spain Join us in Paris for CPhI Worldwide 2015 , the world's leading pharmaceutical networking event, co-located with ICSE, P-MEC and InnoPack. CPhI Worldwide hosts 2,500 exhibitors and 35,000 attendees from 140 countries. Meet face-to-face with international pharmaceutical companies, stay informed about the latest industry trends and remain one step ahead of a constantly changing pharmaceutical market.

Oligo-glycines are either flexible linkers or form well defined rigid substructures. We offer a variety of oligo-glycines as building blocks which can easily be introduced into any molecule.

Surprising behavior of NXO-peptides. It is a significant property of peptides that oxalo-retro azapeptides have the same donor and acceptor distances and properties for hydrogen bridge formation as a tripeptide fragment and therefore induce beta-sheet formation at this position.

August, 6th - 7th, 2015 Molecular Foundry, Lawrence Berkeley National Laboratory Berkeley, CA, USA The Peptoid Summit is a friendly gathering of students, post-docs, and PI’s investigating new directions in bio-inspired polymer research.  Peptoids are a highly designable polymer system, allowing unprecedented control over the their exact chemical structure.  This is leading to advances in a wide range of fields, from biomedicine to materials science.  Our community is growin...

Alkylating the Nitrogen of an amide bond results in peptoid structures, leading to conformational restrains, like N-methylation and allows backbone derivatisation. Applications already have been published with Cilengitide, Piscidin 1, and MC4 receptor agonist.

May 27th, 2015 Radboud University Nijmegen, The Netherlands The annual Dutch Peptide Symposium provides a unique opportunity for academic and industrial researchers working in the fields of peptide-, protein-, and amino acid chemistry to meet and exchange ideas, insights, and expertise. The 2015 edition of the Dutch Peptide Symposium will be held in Nijmegen on May 27.

March 18th-21st, 2015 Technische Universität Darmstadt Darmstadt, Germany The 12th German Peptide Symposium 2015 will take place at the Technische Universität Darmstadt, Department of Chemistry, in Darmstadt, March 18 - 21, 2015. The meeting covers all fields of peptide science  ranging from peptide and protein synthesis, peptide structure to the application of peptides and peptidomimetics in medicine and material sciences.

Wang resins are widely used for peptide synthesis. However, certain side reactions, like diketopiperazin formation limit their use. 4-Methylbenzhydryl resin needs more space and leaves less room for this type of side reactions. Standard “Wang-typical” Fmoc/tBu coupling protocols can be applied.

  March 11th-12th, 2015 Technische Universität München Garching, Germany Latest findings and developments in the life sciences and their implementation in innovative technologies and new products in areas such as pharmaceutics, food and biotechnology will be at the focus of the 9th International Congress 'Forum Life Science' on 11-12 March 2015 at the Technische Universität Munich in Garching.

February 19th-20th, 2015 Deutsche Akademie der Naturforscher Leopoldina Halle/Saale, Germany The "Halle Conference on Recombinant Proteins" provides an unique platform for the exchange of latest scientific and technological findings, know-how and expertise between scientists from academia and industry. Presenters from Pharma industry, Biotech industry and Academia talk about latest developments of protein-based therapeutics covering new formats, modifications, manufacturing, formulation and an...

Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.

October 7th - 9th, 2014 Paris Nord Villepint Paris, France Join us in Paris for CPhI Worldwide 2014 , the world's leading pharmaceutical networking event, co-located with ICSE, P-MEC and InnoPack. CPhI Worldwide hosts 2,500 exhibitors and 35,000 attendees from 140 countries. Meet face-to-face with international pharmaceutical companies, stay informed about the latest industry trends and remain one step ahead of a constantly changing pharmaceutical market.

1,4-substituted 1,2,3-triazole are isosteric to peptide bonds and result in peptide mimetics which even retain activity e.g. in case of certain tyrosinease inhibitors. We offer custom synthesis of Alkyne Amino Acid Analogues as building blocks for triazol formation via Click conjugation. Side chains can represent all natural amino acids or unusual residues. In combination with our alpha-azido acids we can offer the whole range of building blocks to design Click-peptide bond analogues for every proteinoge...

August 31st - September 5th, 2014 National Palace of Culture Sofia, Bulgaria The 33 rd European Peptide Symposium will provide a great opportunity to exchange ideas and to create new collaborations between successful scientists working in the field of Chemistry, Biology and Pharmaceutical industry related to Peptide Science. The event will offer a varied scientific program, including young scientists’ mini symposium, poster sessions, industrial exhibitions and attractive social program.

The presence of catalytic copper, limits the in vivo application of the Click this reaction for several reasons. We offer custom synthesis of Strained Cyclooctynes and Substituted 1,2,4,5- Tetrazines as building blocks for fast Click reactions in the absence of any catalyst.

GABA is a neurotransmitter in the central nervous system of mammals and its deficiency is associated with severe neurological disorders. Statine, a GABA analogue, occurs in several peptide APIs. Derivatives of gamma-amino acid analogues are of continued vital interest for a variety of applications in medicinal chemistry. We have a tool box available to offer a broad range of substituted gamma-amino acids and statines on custom synthesis basis.

September 10th - 12th, 2014 LITEXPO, Vilnius Vilnius, Lithuania Life Sciences Baltics 2014 is the only international forum in the Baltics for world-class biotechnology, pharmaceutical and medical devices experts from all around the world. It provides a unique opportunity to explore the new horizons of partnerships, exchange ideas and seek progress through networking. Discover enormous potential and passion in the field of life sciences in Lithuania and the Baltics – the gateway to emerging market...

July 13th - 18th, 2014 SOCRATE Auditorium Louvain-la-Neuve, Belgium The BOSS -conference is a unique international symposium as it combines lectures delivered by established organic chemists as well as younger rising stars with two prestigious events: a lecture delivered by the recipient of the “Janssen Pharmaceutica Prize for Creativity in Organic Synthesis”, and the “Tetrahedron Chair”: a one-day course on a specific topic in organic synthesis.

Benzotriazol activated carboxylic acids: Fast reaction (within minutes) at room temperature with amines and other nucleophiles under addition of base (in both water and non- aqueous solvents). Stable to racemization when coupling with nucleophiles. High solubility in organic solvents like DMF and DCM. Stable in water.

Novel liposomes built of dPEG-Phospholipids with defined PEG chain length provide prolonged blood-circulation time and improved cellular uptake as administration carriers for drugs, delivering active molecules to the desired target.

May 28th - 30th, 2014 KINTEX, Exhibition Center II Kintex, Korea BIO KOREA 2014 Conference is a worldwide accepted venue and place to discuss and acquire the cutting edge knowledge on various topics including vaccines, clinical trials, regenerative medicine, bio energy, GMO, functional food, technology transfer and licensing to firmly secure the global competitiveness.

May 19th - 21th, 2014 Centro de Investigación Príncipe Felipe Valencia, Spain Unlike other Drug Delivery Symposia that have a broader remit, this unique conference series was specifically established to provide a forum for interdisciplinary exchange of state-of-the-art techniques and advances in knowledge relating to the design, clinical development and commercialisation of Polymer Therapeutics. The key topics discussed during the 10th International Symposium on Polymer Therapeutics are...

May 13th, 2014 Universiteit Utrecht Netherlands The annual Dutch Peptide Symposium provides a unique opportunity for academic and industrial researchers working in the fields of peptide-, protein-, and amino acid chemistry to meet and exchange ideas, insights, and expertise. The 2014 edition of the Dutch Peptide Symposium will be held in Utrecht on May 13.

For most of our products Safety Data Sheets are available online now. Find them in five languages: English / French / German / Spanish / Czech . Simply log in to your account on our webpage and find them on the product description pages.

April 1st - 4th, 2014 Messe München Germany For four decades, analytica has been the leading international fair for state-of-the-art laboratory technology and pioneering biotechnology . No other trade fair in the world covers the range of subjects to do with the laboratory in industry and science in such breadth and depth, and on such a scale.

March 27th - 29th, 2014 Mosbach/Baden Germany The spring meetings of the German Society for Biochemistry and Molecular Biology (GBM) are held annually in the picturesque town of Mosbach to promote the exchange of scientific ideas and education of young scientists. The scientific theme of the 65th meeting is “Molecular quality control of proteins in health and disease”.

Bis Thiol & Amine reactive PEGylated Cross-Linker which has been used for enhanced receptor binding, for the design of long-acting conjugates for type 2 diabetes therapeutics and in reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators.

Phthalimidooxy PEG-based cross linkers form stable oximes with aldehydes, also latent ones as present in carbohydrates. Their reactivity is sufficiently mild for a broad used in creating conjugates with sensitive biologics.

Superior Performance at a Sensational Price! Available as –COOH, -NHS, -Maleimide, -Alkyne, -Azide Half the price of other well-known dyes like Alexa- & Cy-Dyes. Available also in large quantities. Broadly applied in cell imaging, FRET, fluorescence quenching.

Compounds like putrescine, spermidine, and spermine play important roles in a many biological functions. Many of them are excellent targets for oncology studies and other fields of medicinal chemistry. Find in our new brochure Diamines & Polyamines our possibilities for custom synthesis and a set over 100 available derivatives.

Resin especially designed for the synthesis of long and difficult peptide sequences!

October 9th-11th, 2013 Yokohama, Japan Meet our CEO and Mrs. Annick Vancolen and discuss the latest trends and ideas at our booth. Additional we will take part in the partnering and are looking forward to meet you.

Dess-Martin-Periodinane is one of the most useful reagents for the reduction of primary and secondary alcohols to aldehydes and ketones.

Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet  et al . as versatile photoaffinity labeling agents to probe biological receptors.

A prominent luciferase group was first discovered in Coelenterata and the corresponding light emitting molecule was therefore named coelenterazine.

Building Blocks for the synthesis of 2,3-diaminobutanoic acid containing peptides or for Click reactions.

October 10th-12th, 2012 Yokohama, Japan Meet our CEO and Mrs. Annick Vancolen and discuss the latest trends and ideas at our booth. Additional we will take part in the partnering and are looking forward to meet you.

September 2nd - 7th, 2012 Athens, Greece Megaron Conference Centre   With more than 550 submitted abstracts and more than 500 already registered participants coming from more than 40 different countries, the 32nd European Peptide Symposium assures an exciting scientific program.

Press release (german text,  pdf Download-Version ) IRIS Biotech bringt neue Innovationen auf den Markt Das in Marktredwitz in Oberfranken/Ostbayern beheimatete Unternehmen IRIS Biotech GmbH hat durch Intensivierung seiner Zusammenarbeit mit Forschungsinstitutionen den Zeitraum der Markteinführung neuer Produktgruppen drastisch verkürzt. Derzeit kooperiert das Unternehmen mit 35 ausgewählten Herstellern und Universitäten aus aller Welt...

Pressemitteilung ( pdf Download-Version ) IRIS Biotech bringt neue Innovationen auf den Markt Das in Marktredwitz in Oberfranken/Ostbayern beheimatete Unternehmen IRIS Biotech GmbH hat durch Intensivierung seiner Zusammenarbeit mit Forschungsinstitutionen den Zeitraum der Markteinführung neuer Produktgruppen drastisch verkürzt. Derzeit kooperiert das Unternehmen mit 35 ausgewählten Herstellern und Universitäten aus aller Welt...

July 15th - 20th, 2012 Leuven, Belgium The BOSS-conference is a unique international symposium as it combines lectures delivered by established organic chemists as well as younger rising stars with two prestigious events: a lecture delivered by the recipient of the “Janssen Pharmaceutica Prize for Creativity in Organic Synthesis”, and the “Tetrahedron Chair”: a one-day course on a specific topic in organic synthesis. Prof. Erick M. Carreira (ETH Zürich) has accep...

March, 18th - 22th, 2012 Aussois, France Depuis 1986, les RECOB (REncontres en Chimie Organique Biologique) réunissent tous les deux ans des chimistes, des physicochimistes, des biochimistes et des biologistes intéressés par l´interface chimie-biologie. Les 14èmes REncontres en Chimie Organique Biologique (recob14) du 18 au 22 Mars 2012

Spermines and other Biogenic Polyamines interact due to their multi cationic structure with DNA!

Properties of the MiDye Chromophore System: Readily applicable to biolabelling, Click  conjugation protocols and peptide synthesis Stable under buffer conditions (pH 4-8)  and in solid phase peptide synthesis Broadly applied in cell und animal  imaging, tested in FRET systems Available in larger quantities compared  to e.g. Alexa, Cy-Dyes etc. Purities > 85%, supplied as freeze-dried solid powder

H-L-Aha-OH*HCl H-L-Dab(N3)-OH 4-Azido-L-homoalanine (S)-2-Amino-4-azidobutanoic acid hydrochloride Formula:                    C 4 H 8 N 4 O 2 *HCl Molecular Weight:     144,13*35,45 g/mole CAS:  942518-29-8 CODE:  HAA5730 1g:       EUR    200,-    US$    300,-  5g:   ...

Reported applications: Introduction of 9-fluorenylmethyloxycarbonyl, trichloroethoxycarbonyl, and benzyloxycarbonyl amine protecting groups into O-unprotected hydroxylamino acids using succinimidyl carbonates; Anelka Paquet; Can. J. Chem. ; 1982; 60: 976. Widely Applicable Deprotection Method of 2,2,2-Trichloroethoxycarbonyl (Troc) Group Using Tetrabutylammonium Fluoride; Cheng-yuan Huanga; Ning Wanga; Katsumasa Fujikia; Yuji Otsukaa; Masao Akamatsua; Yukari Fujimotoa; Koichi Fukasea; Journal o...

Cleland's reagent, also known as dithiothreitol or DTT is a water soluble protective reagent for sulfhydryl groups. It reduces disulfide linkages to free sulfhydryl groups in proteins and enzymes. It is a component of buffers used in protocols for the isolation and purification of proteins. DTT (racemic), Cleland's Reagent

Dendrimers offer a new possibility to derivatize small molecules, surfaces or biopharmaceuticals with a monodisperse macromolecule and alter in this way properties like solubility and hydrophilicity. Immunogenicity and pharmacokinetics of pharmaceuticals will be improved. The synthetic approach for designing these dendrons of different generations is based on 2,2-bis(hydroxymethyl) propionic acid, which is a non-toxic and biocompatible building block. The size can be designed from 250 g/mole for 1st gene...

Abstract: Trypsin digests peptides at the position of arginine. Because shorter homologues of arginine with appropriate protecting groups for conventional Fmoc/tBu peptide synthesis are now available, three model peptides containing arginine and two shorter homologues of arginine were synthesized.

Abstract: N alpha-9-Fluorenylmethoxycarbonyl-N epsilon-4=methyltrityl-lysine, [Fmoc-Lys(Mtt)-OH], was prepared in two steps from lysine, in 42% overall yield.