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Benefit of our latest Maillard Reaction Product additions! Use them as reference standard for quality control and food analysis or synthesize modified peptides for research studies.

Looking for methods to selectively modify your peptide’s N-terminus ? Discover triazolecarbaldehydes and benefit of mild reaction conditions, high yields, and compatibility with aqueous media.

Game Changer for Protein Modification: Discover oxidation-induced furan crosslinking and 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones ( 5HP2O s) as stable alternative to maleimides.

5 December, 2024

Discover CysGluDan, a new fluorescent probe for the detection of reactive metabolites in drug development, which can detect both "soft" and "hard" nucleophiles. 

We expanded our portfolio of Fmoc-protected homo amino acids . Benefit of their unique properties to modulate the stability, hydrophobicity, and biological performance of your peptide!

November 28-30, 2024

November 14, 2024

HMPO (5-(hydroxymethyl)pyrogallol orthoester), a plasma-stable, pH-sensitive, 1,6-self-immolative crosslinker derived from the natural product gallic acid. Discover its properties!

Discover MYTsA as coupling reagent for peptide synthesis in “traditional” C→N and vice versa in “natural” N→C direction. Avoid racemization and benefit of improved atom economy!

You missed our Workshop with Prof. Thomas Carell? As unpublished data was shown, the recording of the workshop will just be available on our homepage in a few weeks. If you would like to be informed please get in contact via info@iris-biotech.de.

Tetrahydropyranyl (THP) is an excellent protective group for hydroxy and thiol moieties but rarely used in solid-phase peptide synthesis (SPPS). Discover its advantages, e.g., over O/S t Bu and Trt.

Collect information about the most common side reactions during Fmoc SPPS and how to avoid them! Choose your building blocks and conditions wisely to avoid unnecessary trouble!

To address both chemical and IP considerations in self-immolating linker applications , we propose shifting from the commonly used Val-Cit-PAB linker to the less explored Gly-Gly-Phe-Gly-formyl motif.

Discover the diversity of TentaGel® Resins ! Read our blog to get more information about our latest product additions and possible applications and find the right resin for your research endeavors!

October 14-15, 2024

October 9-11, 2024

Where does life come from and how can we simulate early earth conditions leading to simple organic molecules such as nucleotides and amino acids, the building blocks of RNA and peptides?

October 8-10, 2024

Green – Yellow – Red – Grey. To increase transparency in terms of expected shipping times, we have introduced a color code in our webshop indicating product and packing unit availabilities.

Cyclophase Synthesis - Dissolve. React. Precipitate. Filter. Repeat! Make your peptide synthesis greener by avoiding DMF and benefit from the advantages of both liquid and solid phase synthesis.

September 9-11, 2024

Take part in our survey to rate the quality of our brochures in terms of layout, provided information and prices, scientific references, and user-friendliness. Thank you!

Same but different! Expand your possibilities for peptide modification and fine-tuning by implementing N ω -carbamoylated arginine building blocks as bioisosteric arginine analogs.

August 25-29, 2024

Mix & Match. Discover typically employed protecting groups used to temporarily mask reactive functional moieties during solid-phase peptide synthesis to prevent undesired side-reactions.

Shaken, not stirred. Amino-Li resin – a cross-linked polyacrylic amide solid support suitable for the synthesis of peptides and biomolecules, which is compatible with organic as well as aqueous solvents.

Let’s make scientific progress together! To support especially young researchers, we now are granting a general discount of 5% on catalog items / quantities to universities and non-profit research institutions. 

What’s new? Don’t miss innovative building blocks and latest technologies – have a look at our new products flyer and discover our portfolio additions from January to June 2024!

Get the most out of your synthesis! Monitor your deprotection and coupling steps for completion and optimize your reaction protocols to maximize yields and minimize side-products! 

Novel excipients can help you master the challenges associated with the production and formulation of protein- and RNA-based drugs due to their inherent fragility. Discover the SURPAX TM technology!

July 22-23, 2024

July 2-3, 2024

Encode beads with unique tags for combinatorial syntheses & screening. Build libraries & identify hits. Discover properties and applications of our novel bifunctional TentaGel® resins.

Wondering about the difference between Boc and Fmoc chemistry in solid phase peptide synthesis? Don't worry: in this short overview we will guide you through the basics of both strategies.

Proposing norbornenes – strained, bicyclic alkenes for fast, copper-free, biocompatible click-conjugation with tetrazines. Read on for more details on applications and available products!

June 10-12, 2024

Clever Move - Add positive effects to your molecule by introducing the most electronegative element. Discover fluorinated building blocks as game changer for your lead development. 

Level up! Carboxymethyl-modified amino acid building blocks suitable for incorporation by solid-phase peptide synthesis. Learn more about available derivatives and their properties.

Discover photocages – photosensitive protecting groups that are removed by irradiation with light of a defined wavelength, thus restoring the original, “active” state.

June 2-5, 2024

May 8th - 10th, 2024

Have an additional ace up your sleeve for selective and efficient peptide modification, cyclization, and/or bioconjugation. Explore 2-cyanopyridines for click-like reactions. Get more information!

Beyond cysteines: Unlock targeted side-chain modifications of your peptides and proteins via the introduction of 1,2-aminothiols and subsequent click-like functionalization. 

29 April - 1 May, 2024

Engineer shape-shifting peptides , controllable by a laser as magic wand! In this newsletter, we’ll explore the possibilities of photo switchable building blocks based on azobenzene.

You are looking for monodisperse Sarcosines ? You want to use Sarcosine for SPPS? You need to improve your drug's hydrophilicity and search for PEG alternatives? Read on!

You missed our workshop featuring Dr. Fabio de Moliner & Prof. Dr. Marc Vendrell? Watch the Recording! Any further questions? Please get in contact via info@iris-biotech.de.

April 22-23, 2024  

Boron is not boring at all! Today, we'll delve deeper into the exciting world of boronate-containing amino acid building blocks and unlock the potential of the next generation of peptides. Read on!

The targeted delivery and traceless release of drugs is an important concept in pharmacology. Discover the possibilities of payload conjugation to carrier proteins shown for the example drug Elacestrant.

Explore phenylisopropylesters (OPP/OPis) as carboxy protecting groups. Facilitate your peptide synthesis with building blocks for precise side chain modifications or seamless macrolactamizations. 

You are looking for a building block suitable to control the folding characteristics of your peptide or want to add a pH-sensitive conformational switch? Discover aminoprolines and their properties!

March 18-20, 2024

Live-imaging of dynamic structures and catching events in living cells is a challenge, as most fluorescent probes have a high background signal. For alternatives, please read on!

Are you keen on developing novel billion-dollar-selling peptide API blockbusters? Most recent ones use lipophilic Albumin binding moieties. Of course, Iris Biotech has the necessary building blocks!

The tetrazole isostere of malonyllysine is thermally stable and does not suffer from decarboxylation. Discover our building blocks suitable for incorporation via solid-phase peptide synthesis.

REACH regulation for the handling of N , N -dimethylformamide (DMF), the most commonly used solvent for solid-phase peptide synthesis (SPPS). Read more about consequences and alternatives!

Increase your peptide’s stability, introduce an NMR label for analysis, or enhance lipophilicity. Read our blog to discover our latest toolbox additions in the field of non-canonical amino acids.

Our special Christmas offer is still valid! Get our standard L-amino acid bundle with 30% discount compared to standard prices. Choose your packaging unit!

Curious about the highlights of our 2023 portfolio additions? Discover innovative building blocks and latest technologies! Read on to check out the summary or get in contact if you need more details!

January 28 - February 1, 2024

The festive season already started and with it, the year is drawing to a close. We would like to thank you for your trust and the pleasant cooperation in 2023.

Discover possibilities to fight chronic pain diseases by employing linker technologies. Check out the options for multiple drug conjugation in combination with different release mechanisms.

Do not miss our special Christmas offer starting on December 1st!

Add glycans to your proteins with our ready-to-use Fmoc asparagine building blocks suitable for solid phase peptide synthesis and produce peptides with exactly defined glycosylation patterns!

December 5, 2023

The discovery of the Merrifield peptide synthesis paved the way for automated solid-phase peptide synthesis (SPPS) enabling fast and convenient simultaneous peptide synthesis.

Discover our small-sized, neutral Fmoc-protected nitrobenzoselenadiazole- and nitrobenzothiadiazole-modified amino acids suitable for SPPS of fluorescent peptides. 

One molecule, two identities: PNAs are composed of nucleobases arranged on a peptidic backbone. Discover our PNA building blocks as ready-to-use bases suitable for SPPS.

November 29-30, 2023

November 27-29, 2023

Sick of Lysine side chain protecting groups jumping around, yielding scrambled peptides? Check our various options to fine-tune protecting group stability vs. cleavability to optimize your peptide yield.

A heart of gold! Metals and ores - see here how their surfaces can be equipped with bifunctional organic linker molecules and thus be turned into modifiable biocompatible materials.

Ongoing research efforts lead to the discovery of innovative building blocks and new APIs. However, for industrial applications, upscaling is required. Herein, we share the process development for Fmoc-Cys(Msbh)-OH.

Keeping control! PEGylating reagents with a squaric acid ethyl ester react chemoselectively with side chain amino functions of surface-accessible Lysines in proteins. Other functionalities are not affected.

October 24-26, 2023

October 26-28, 2023

Discover our new building block 4-(azido-propyl-tetrazine)phenylalanine (pTAF) and make use of the orthogonality of the 2 nd and 3 rd generation Click reaction to build multiconjugates via double-Click.

You want to attach your small molecule to a certain carrier? Let’s analyze the functional groups present and discuss Linkerology® possibilities for permanent or trigger-inducible, tracelessly-cleavable linkage.

October 15-20, 2023

October 10 - 13, 2023

Bioengineering in combination with Linkerology® . Check out the unique options for membrane proteins, recombinant immunotoxins (RITs) and novel antibody-drug conjugates.

September 17 - 21, 2023

TCEP is an effective reductant for disulfide bonds and a versatile reagent for various applications in protein science with distinct advantages compared to DTT and BME.

The potential of natural products of daily life , such as 6-shogaol from ginger ( Zingiber officinale) , can flourish if the active ingredient is conjugated to an appropriate carrier via Linkerology®. 

September 6-8, 2023

September 4 - 5, 2023

August 28 - 30, 2023

Allotropes of carbon show distinct characteristics in structure and e.g. electric and biophysiological properties. Discover how these materials can be further exploited by linker attachment!

Discover the cyanobenzothiazole (CBT) click reaction , a not (yet) so well-known biocompatible and bio-orthogonal mechanism faster than the famous azide-alkyne cycloaddition (CuAAC).

Curious about our latest portfolio additions from January to June 2023? Discover our New Products Flyer and check out the summary of recent product highlights! Get in contact for more details!

Add a new dimension of orthogonality to your peptide synthesis by using Safety-Catch arylalkyl sulfoxide protecting groups! This newsletter tells you about benefits and usage – Read on!

Discover our diazirine-substituted building blocks suitable for the analysis of protein-protein and RNA-protein interactions via proximity labeling upon photoactivation. Read on for more information!

Plasma technology allows to equip inert polymers such as poly(ethylene) or polystyrene with functional groups like amine or carboxylate enabling further conjugations and applications. Read on!

June 24th - 29th

Our building block Fmoc-L-Cys(Cam)-OH enables peptides resembling reduced and carbamido-methylated protein fragments by standard SPPS without error-prone modification reactions.

Plant-derived Cholesterol of high and consistent product quality in accordance with Pharmacopoeia requirements to replace established animal source material in LNP formulation. Read on!

Shine bright like our fluorophores! Learn how our superior fluorogenic protease substrate peptides can enhance your test performance. Click here to gather more information and discover available products!

Infinite like the deep sea – marine natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.

June 5th - 8th

Building blocks with a strained triple bond do not require copper catalysis when used in click chemistry. Discover CliCr®: improved solubility in aqueous conditions and high reactivity! Click here!

Peptide therapeutics – fewer injections/lower doses by prolonging their half-life via addition of a lipid modification that promotes binding to serum proteins such as albumin. Read on for recent innovations!

From beginning of May until end of July 2023 we offer special polysarcosine bundles each containing three functionalized PSars of different molecular weight (5 kDa, 10 kDa, 15 kDa), 100 mg each.

May 10th - 12th

April 26th - 28th

From evolution to solution - natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.

Our monofunctionalized dextrans are enriching the toolbox of polymer therapeutics – Dextrans benefit of excellent solubility, biocompatibility, biodegradability, and non-immunogenicity.

April 21st

Non-canonical Tryptophan analogs can help to improve your API’s performance in terms of potency, specificity, and stability. We offer various substituted Trp derivatives also available in small quantities for screening.

Coupling Reagents are required for the formation of an amide or ester bond. As simple as those reactions seem to be, the choice of the appropriate reagent is crucial for optimizing purity and yield.

You missed our workshop featuring Prof. Christian F. W. Becker (University of Vienna)? Any further questions? Please get in contact via info@iris-biotech.de.

Maleimides provide versatile options for connecting payloads to proteins and other biomolecules. Discover how our bifunctional thiol reactive crosslinkers can support your project. Read on!

Herein, we present functionalized perfluorobiphenyl building blocks which can be used for site-selective π -clamp mediated cysteine conjugation. Read on for more details about this general method!

PEGs are being used as spacers, as hydrophilic decoration, and building blocks. Read on for more detailed information about the reactivity of different PEG derivatives and how to use them.

We are pleased to serve as your platform – either to highlight your science performed with our building blocks or to market innovative building blocks you are developing! Read on for more information!

March 9th - 12th, 2023

Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!

February 28th - March 2nd

February 23nd - 25th

The HaloTag®, SNAP-Tag® and CLIP-Tag TM represent versatile tools for the specific, covalent attachment of in principle any molecule of choice to a protein of interest. Discover our substrates!

(Bi)functional dioxoborolane and disulfide-based self-immolative linkers – mode of action and application examples for the detection of H 2 O 2 , for prodrug design, and reversible peptide cyclization.

You want to get an overview about the different Click technologies as well as available derivatives and applications? Let’s arrange a (virtual) talk by Iris Biotech about your topic of choice – Contact us!

Herein, we present CliCr® as an innovative cyclic alkyne for metal-free strain-promoted click chemistry. Read our blog for detailed information about CliCr® reagents based on TMTHSI and check out available derivatives!

In two joint studies together with Prof. F. Albericio we investigated the coupling efficiencies of Ser and Thr pseudoproline monomers and their use for the synthesis of inaccessible peptide sequenes. Read on!

Curious about our latest portfolio additions from July to December 2022 and the 2022’s overall product and newsletter highlights? Click here to check out the summary or get in contact for more details!

Herein we investigate the incorporation of the Fmoc-Thr-pseudoproline monomer during Fmoc SPPS. Typically, pseudoprolines are incorporated as preformed dipeptides. However, the possibility of using the monomer adds flexibility to the synthesis.

We can’t get enough of new products and innovations! Read this blog to get detailed information on the cyanylating reagent NTCB as well as selenocysteine amino acids, both useful tools for peptide ligation.

Jensen et al. developed two methods that use poly-His sequences to direct the highly selective acylation of proteins, either at the N-terminus or at a specific Lys residue. Read on for more information.

See how our “mRNA grade” DTT and Spermidine can support also your nucleic acid production. Read on for more information.

Linkers serve as versatile tools, e.g. during SPPS or for the sophisticated (self-immolative) conjugation of a potent small molecule to a carrier. Check out our selection of over 100 readily available linkers.

The 2022 Chemistry Nobel prize is awarded to B. Sharpless, M. Meldal and C. Bertozzi for their work in the field of Click Chemistry. At Iris, we are providing clickable building blocks for nobel chemistry. Read on for more information!

The ChemMatrix® resin production and distribution was discontinued by its manufacturer SEQENS. Products are only available at Iris till current stock is sold out. Read on for more information!

November 1st - 3rd

October 11th - 14th

We refreshed our topic-specific brochures. All of them are accessible via our website and can be downloaded free of charge. Click here to check-out the overview of available brochures.

You are working on complex peptides and are looking for a new level of orthogonality facilitating the overall synthetic process and improving your yields? Check out the Msbh safety-catch protecting group!

From mg synthesis of a peptide up to bulk quantities often makes a huge difference in the route of production. Read on for more information about Iris Biotech’s process development services.

1,4-Benzenedimethanethiol is used as thiol scavenger during solid-phase peptide synthesis. In comparison to other thiol scavengers, this reagent is odorless and provides high quality crude peptides.

No matter how much you hate them, in the pharmaceutical world you have to deal with them: Impurities. Iris Biotech can provide you with the molecules you require. Click here for more detailed information.

Read on for detailed information on the results of our comparative study on different methods to tackle aspartimide formation. Click here!

As the molecular diversity of cyclic and branched peptides becomes more and more challenging, a high level of orthogonal dimensionality is required. Herein, we present a new category of orthogonal protecting groups.

Herein, we report the first-time SPPS of a special peptide sequence via employment of of a serine pseudoproline building block as well as sec-isamyl mercaptan (SIT) as cysteine protecting group.

Herein, we present the Clean Peptide Technology using Smoc Amino Acids developed by Sulfotools in Germany. Replace organic solvents with water during peptide synthesis - Read on for more information!

You want to get an overview about the various resins available at Iris Biotech as well as their specifications, differences, and applications? Read on for further information and details.

We refreshed our topic-specific product flyers. All of them are available on our website for download free of charge. Click here to check-out the overview of the available flyers.

You just started working in the field of solid phase (peptide) synthesis and want to get familiar with resins? Click here to get an overview about the different parameters describing resins.

We are highly excited to see the research that our products are used for. Send your peer-reviewed scientific publication to publication@iris-biotech.de for citation – we will reward you.

Herein, we present 2-Iminobiotin, a cyclic guanidino analogue of biotin with pH-dependent affinity for avidin, and compare it to biotin and desthiobiotin. Click here for more detailed information.

The Dawson Linker and its variants provide access to C-terminal peptide thioesters which are crucial components of Native Chemical Ligation reactions. Read on to discover all derivatives available at Iris Biotech!

Are you active in the field of antibody drug conjugates? Click here to find out more about our selection of as well as the technology behind pH-sensitive self-immolative linkers.

June 27 th - 29 th 2022

The para -azido benzyloxycarbonyl protected lysine building block Fmoc-L-Lys(4-N3-Z)-OH (FAA8830) is useful for a wide range of applications. Read on to find out more!

Photoswitches grant the ability to modulate the function of a molecule by effecting a structural change upon irradiation with UV light. Find out about our photoswitchable building blocks and their properties.

You missed our workshop featuring Prof. María Jesus Vicent Docón (Head of Polymer Therapeutics Lab)? Any further questions? Please get in contact via info@iris-biotech.de.

June 13 th - 16 th 2022

June 11 th - 16 th 2022

Dyes and fluorescent labels are an invaluable tool for diagnostics, medical and biochemical research. Iris Biotech offers labels with excitation ranges from UV to near-IR and various functional groups.

We want to support you in the development of next generation peptide pharmaceuticals, therapeutics, and diagnostics by easing the process of peptide manufacturing. Read on to gather more information.

For selected products we added minimum purity and minimum enantiomeric purity as part of our product description on our website. High product qualities at Iris Biotech – Read on for more info.

Replace undesired solvents such as DCM, THF and DMF during the loading of 2-CTC and 4-MBH-Br resin by a “greener” EtOAc/MeCN (1:1) mixture. Click here and read on for more details.

Discover our products suitable for drug delivery including poly ethyleneglycols (PEGs), poly amino acids (PArg, PGlu, PLys, POR, PSar), poly(oxazoline)s, as well as fullerenes. Read on to find out more!

Iris Biotech is your trusted partner in the world of peptides and all related disciplines. Your project requires a compound not listed in our portfolio? Get in contact and inquire for a custom synthesis!

Drug the undruggable – click here to get more information about the use of PROteolysis TArgeting Chimeras (PROTACs®) as a tool for targeted protein degradation and discover available building blocks.

Iris Biotech offers the main building blocks for the synthesis of Liraglutide and Semaglutide and commonly observed impurities as well as reference standards. Read on for more information!

We are providing variously functionalized, protected and unprotected fatty acid derivatives suitable for SPPS and further conjugation, e.g. via Click chemistry. Read on to discover our portfolio.

May 29 th - June 3 rd  2022

Oxidation is not only a known degradation pathway of proteins and peptides in vivo but is also a major side reaction for certain amino acids during peptide synthesis in vitro. Read on to discover our available building blocks.

Discover our selection of disulfide-based self-immolative linkers allowing to influence linker stability, fine-tune the self-immolative cleavage rate and thus impact the speed of the payload release.

Interested in polymers for the delivery of promising drug candidates, e.g. nucleic acids? Discover our selection of lipidated polyamino acids and custom capabilities. Read on to find out more!

Interested in the introduction of Sarcosine (N-methylglycine), e.g. for hydrophilicity increase of your derivative of choice or for PEG replacement? Check-out our available Sarcosine building blocks!

Herein, we present building blocks for the synthesis of protected hydroxylamine derivatives which can be further used for bio-conjugation and various other applications. Read on to find out more!

Discover our selection of propargyl-substituted amino acids and find the best position for subsequent Click chemistry within your peptide/protein. Just click here for further information on our products.

April 20 th - 22 nd  2022

Looking for an acid stable protecting group? Struggling with undesired loss of the Cbz protecting group while removing Boc under acidic conditions? Read on to find out more about iNoc as alternative.

Stable isotopically labeled drugs are routinely used to investigate a drug’s metabolism, distribution, bioavailability, side effects and potential toxicity. Discover our selection of labeled drugs.

Discover our selection of substrates for Halo-, Snap-, and Clip-tagged proteins bearing different terminal groups suitable for further functionalization, e.g. biotinylation and Click chemistry.

Herein, we summarize certain product highlights and innovations, which we presented in our newsletters 2021. Have a look and get in contact for more information or an individualized offer.

See a summary of our advent calendar surprises and benefit from special discounts and great offers! Interested? Just click here to check-out all available products.

Common protocols for the loading of 2-CTC and MBH-Br resins presume the application of DCM, THF, or DMF; these solvents are considered as undesirable in accordance with modern regulatory rules.

You missed our workshop featuring Prof. Dr. Fernando Albericio (University of KwaZulu-Natal & University of Barcelona)? Any further questions? Please get in contact via info@iris-biotech.de

Herein we present a series of alpha,alpha-cycle-disubstituted amino acid derivatives used in peptide design for their structure promoting effects as well as conformational rigidity.

Herein we are reporting on the linker stability of amino-PEG-acids achieved via N-methylation and the possible side-reaction without this additional modification. Read on to find out more!

Typically known and employed as preformed dipeptides, we are presenting Serine- and Threonine-derived Pseudoproline monomers as building blocks for solid-phase peptide synthesis.

Check out our growing portfolio on adamantyl-substituted amino acids and building blocks. At Iris Biotech, we are constantly striving to improve our services, our products, and the routes of synthesis.

Discover our selection of Halo ligands as haloalkane dehalogenase substrates, bearing different terminal functional groups suitable for further conjugation, e.g. via Click chemistry.

Polysarcosines (PSars) – a true alternative to polyethyleneglycols (PEGs) - stand out in terms of safety, synthetic control, and versatility. Interested? Read on to find out more about their properties.

October 25th – 28th, 2021

Back in the lab after enjoying your holidays? Motivated to run new experiments but lacking certain building blocks or standards? Check out our huge portfolio or get in contact for our special offers!

Discover the versatile applications of hydrazone resins e.g. for the preparation of peptide hydrazides, or the generation of peptide thio esters. Read on to find out more and see our available products.

You missed our workshop featuring Prof. Dr. Jeffrey W. Bode (ETH Zurich)? Any further questions? Please get in contact via info@iris-biotech.de

Selenocysteine (Sec) plays a crucial role for various biological processes, and selenoproteins can be found in all lineages of life. Read on to discover the 21 st amino acid, its derivatives and applications.

Read on for more information about the right handling of Maillard Reaction Products (MRPs), which are frequently used as analytical standards related to food quality and disease processes.

September 27th - 30th, 2021

Herein we are presenting 2-(Fmoc-amino)-3,3-diMe-pent-4-enoic acid (FAA5040), a protease stable Ile/Leu surrogate suitable for further modification via its side chain double bond.

September 20th - 24th, 2021

Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.

Iris Biotech offers a variety of (functionalized) biotin and desthiobiotin reagents reactive towards certain functional groups. Discover our growing portfolio and latest additions.

Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which can be elongated by Fmoc-SPPS and can easily be linked to amino-functionalized solid supports. Read on to find out more about their advantages.

Compounds of the shown formula can simply be bound to solid supports via amide bond formation without racemization of the C-terminal amino acid and enable the synthesis of very pure peptides.

The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.

The incorporation of alpha-trifluoromethyl substituted amino acids into peptides increases proteolytic stability, enhances lipophilicity, and induces secondary structures. Read on to find out more!

Interested in structure-activity studies of your Proline-containing peptide drug? Find out more about the use of Methanoprolines and Dimethylprolines as conformational amide locks.

With the approval of several COVID-19 vaccines and drugs in recent months, hope is growing that the current pandemic will end soon.

July 7th - 9th, 2021

Iris Biotech offers various (protected) azide- and alkyne-modified fatty acid derivatives suitable for Click Chemistry. Interested? Read on to find out more!

Serine- and Threonine-derived oxazolidines as well as Cysteine-derived thiazolidines, so-called Pseudoprolines, serve as structure-disrupting, solubilizing building blocks in peptide synthesis.

Iris Biotech offers hetero-bifunctional crosslinkers bearing an N-hydroxysuccinimide (NHS) ester and a maleimide group suitable for the reaction with amine- and thiol-containing molecules.

Read on to find out more about Iris Biotech’s Linkerology® portfolio including substituted pyridyldithiols as building blocks for the reversible chemical conjugation to sulfhydryls.

You missed it? We are pleased to provide the full-length recording for your convenience! Any further questions? Please get in contact via info@iris-biotech.de!

June 14th – 17th, 2021

Interested in studying the effect of palmitoylation on your peptide’s localization, function, and stability? Read on to find out more about the use of lipidated “fatty” amino acids!

Cys(Aapam): an Alloc protected Phacm linker as removable side chain modification for the incorporation of e.g. solubilizing tags facilitating the preparation of hydrophobic peptides and proteins.

Interested in structure activity studies on your Arginine containing peptide or further optimization for improved receptor binding? Explore our guanidino Proline derivatives as rigid Arginine mimics.

Hurrah! We are celebrating our 20th anniversary with a refreshed company logo. Interested in the evolution behind? Click here to find out more!

Are you using the Fmoc-MeDbz-OH Dawson Linker in large scale on a regular basis? A robust and economic processallows us to promptly provide you with kg quantities at competitive prices and in high quality.

Herein we present substituted diazacyclononynes (DACNs) as versatile tools for metal-free strain-promoted Click Chemistry that are characterized by high reactivity and stability, both thermally and chemically.

Fmoc-Asp(CSY)-OH – an innovative building block to suppress aspartimide formation during peptide synthesis by utilizing cyanosulfurylide as carboxylic acid protecting group. Read on to find our more!

The highly lipophilic, bulky adamantyl motif is a promising and validated building block to increase the drug-qualities of lead compounds without increasing their toxicity.

An efficient, versatile linker developed for the synthesis of C-terminal primary/secondary amides and hydrazides as well as peptide alcohols, which is compatible with SPPS and suppresses side reactions.

Herein, we present aminooxy-amino acids reported for peptide synthesis via oxime ligation, cyclization via oxime formation, derivatization e.g. by glycosylation, or chelation. Read on to find out more.

March 24-26th, 2021

Herein we present two arginine derivatives, in which the native guanidino group is replaced by an isosteric amino-functionalized carbamoylated guanidino group that can serve as an attachment point for further derivatization.

Frustrated by aspartimide formation during peptide synthesis? Iris Biotech presents aspartate derivatives with bulky side chain protecting groups that minimize the formation of aspartimide-related side-products.

March 8 - 11th, 2021

The new disulfide-based protecting group sec-isoamyl mercaptan (SIT) is fully compatible with Fmoc- and Boc-SPPS and can easily be removed reductively upon addition of dithiothreitol.

Cyclopropanes represent important design elements in medicinal chemistry and are widely present in drug compounds. Read on to find out more about their full potential.

March 4, 2021

The sterical interference of three closely positioned methyl groups favors amide cleavage and payload release upon lactonization. This cascade can be induced by various triggers. Read on to find out more.

The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.

January 19, 2021

Interested in the formation of peptide thioesters for Native Chemical Ligation? Read on to find out more about the use of Dawson Linker derivatives as thioester surrogates compatible with Fmoc SPPS.

Enzymatically-activatable probes based on 7-amino-4-methylcoumarin (AMC) represent versatile tools for the detection and localization of proteolytic enzyme activities. Read on to find out more.

Methionine is particularly prone to oxidation by atmospheric oxygen in vitro but also by reactive oxygen species in vivo, resulting in the corresponding sulfoxide and sulfone. Read on to find out more.

One approach for the design of bioactive peptides with improved pharmacological properties is the derivatization of amino acid building blocks with fluorine. Find out more about the advantages of fluorinated peptides.

The thiosuccinimide linkage is a prominent connective motif resulting from the reaction of a thiol and an alkyl maleimide. Read on to learn more about its applications and potential improvements.

Mpro is a key enzyme of coronaviruses (coronaviridae) and thus an attractive drug target. Iris Biotech offers fluorescent substrates, which can be used to perform various types of screenings and to identify potential inhibitors of COVID-19.

Interested in histidine derivatives? Iris Biotech provides a selection of deamino- and decarboxy-products. Find out more about benefits and potential applications of our new building blocks.

Fighting COVID-19 by modifying essential viral proteins via glycation through methylglyoxal – a reactive carbonyl compound known from the Maillard reaction. Read on to find out more!

Iris Biotech offers various linked kinase inhibitors including analogues of Gefitinib, Imatinib, Sunitinib, Staurosporine and many more, which can easily be conjugated to other biomolecules, if desired. Have a look and read more.

Iris Biotech presents its selection of Val-Cit-based linkers, a dipeptide motif frequently utilized for the development of ADCs with increased serum stability and high cleavage efficiency.

Nitrodibenzofuran (NDBF) is a photocleavable side chain protecting group that can be removed by photolysis upon irradiation with UV-light or – especially for in vivo applications – by two-photon excitation using near infrared light.

Iris Biotech presents (functionalized) fullerenes of different core size (C60 vs. C70) as versatile tools for multiple functionalization. Read more about their unique properties and fields of applications.

Iris Biotech presents the next-generation of hydrolysis-stable phosphono-analogs of pSer, pThr and pTyr. Fluorination renders the phosphonic acid more acidic and thus an even better mimic of the parent phosphoamino acid.

Looking to optimize or functionalize your peptide? Explore our ever-growing selection of Arg derivatives and find the one suitable for your application.

Isopropyl-β-D-thiogalactopyranoside (IPTG) is one of the most commonly utilized reagents in molecular biology.

Find out more about those building blocks with side chains able to coordinate metal ions, and why peptide-based HDACis are intriguing synthetic targets.

Welcome at Iris Biotech - Josephine Wendt joined our team by September 1st, 2020.

Learn, how His-Tag can be used for specific linker attachment. Another example in our LINKEROLOGY series of sophisticated linker technologies.

We, Iris Biotech GmbH, are pleased that Dr. Thomas Bruckdorfer completes the BIOPARK8-Brain-Network in Regensburg and will enrich it with our experience.

Amongst various somatostatin analogues, the pentacyclic heptapeptide TT-232 bears unique properties. Iris Biotech offers TT-232 as triacetate and trifluoroacetate salt, respectively, as well as conjugated to either biotin or the fluorophore indocyanine green.

Find out which Maillard Reaction Products from Iris Biotech were used in the development of a state-of-the-art analytical method for 15 different AGEs.

Empowering Peptide Innovation – now also via Twitter! Iris Biotech is excited to present news, our latest products and brochures, upcoming events and more. Follow us at @IrisBiotechGmbH and #Iris Biotech GmbH to stay tuned.

The ever-growing sophistication and variation in linker design have given rise to a new and distinct field of knowledge in synthetic chemistry termed Linkerology. Discover our expertise and panoply of new cutting-edge tailor-made linker constructs for the latest state-of-the-art bioconjugations.

Iris Biotech GmbH is excited to present its latest developments. Interested in details on the different product categories? Please get in contact, we are pleased to provide further information on the topic(s) of your choice and discuss potential applications, e.g. via a Microsoft Teams product presentation.

Alkyne amino acids allow for Click conjugations and other types of chemistry. Read more about alkyne-functionalized amino acids and our related products.

The integrin receptor interacting RGD sequence and related peptides act as promising tools for drug therapy and cancer research. Find more information on our portfolio of cyclic RGD peptides.

Iris Biotech offers L-Cysteine Hydrochloride Monohydrate from Cystine, which is produced by fermentation of Escherichia coli .

DTT is a powerful yet mild reducing agent. Based on your demand we can offer different quality grades to suit your needs.

Sidechain-derivatized amino acids have shown great potential in enhancing select properties of peptide lead compounds. Find the most recent additions to our portfolio of amino acids bearing additional aryl and alkyl groups in their side chains.

Peptide purification after SPPS usually requires time- and solvent-consuming HPLC, which is often limited by co-eluting side-products. Belyntic’s catch-and-release PEC-Linker chemoselectively catches the desired product from your crude to reach a new dimension of purity.

The tremendous success of Liraglutide and Semaglutide has moved amino acids modified with lipids into the focus of many research endeavors. Delve into the treasure trove of our lipidated amino acids!

The presence of phenyl groups in APIs is connected with various disadvantages. An increasingly popular solution is the use of BCP as a phenyl ring bioisostere. Find out more about this highly diversifiable motif.

Beginning of March 2020 Iris Biotech implemented measures in order to minimize the impact of and the risks associated with the current pandemic. As of 26 March 2020, Iris Biotech is classified as system-relevant .

27 - 29 April 2020

23 - 24 March 2020

Our distribution partner in Mumbai / India, Sumit Biosciences Pvt Ltd., recently opened a new warehouse in Mumbai to stock various Iris Biotech products from our amino acids and resins product ranges. Stocked pack sizes range from 5 g to 1 kg.

Betulin and its derivatives are pentacyclic triterpenoids of the lupane-type. They are natural products that occur as secondary metabolites in over 200 different plants. Betulinic acid (BA) is a derivative of betulin that is oxidized at C-28.

29 - 31 January 2020

27 - 29 January 2020

19 - 23 January 2020

Arginine, a semi-essential amino acid, is involved in various important metabolic processes.

Biotinylation of proteins and their purification via Streptavidin beads is a widely applied method.

Proximity labeling of proteins with biotin-phenol (biotin-tyramide) and an engineered peroxidase enzyme (e.g. APEX = Engineered Ascorbate Peroxidase) is a pivotal tool for molecular biology.

Wir freuen uns Ihnen unsere drei neuen Teammitglieder vorstellen zu dürfen: Frau Lusine Davtyan (li.) absolviert bei der Cfm Oskar Tropitzsch GmbH ein 6 monatiges Praktikum im Bereich Gesundheitsmanagement. Frau Celine Pohlers (mi.) begann eine Ausbildung bei der Cfm Oskar Tropitzsch GmbH als Kauffrau Groß- und Aussenhandel, Fachrichtung Aussenhandel. Frau Sina Weichold (re.) begann die selbe Ausbildung bei der Iris Biotech GmbH. Wir wünschen unseren jungen Mitarbeiterinnen viel Freude bei ...

22 November 2019

12 - 15 November 2019

5 - 7 November 2019

21 - 22 October 2019

The Allocam protecting group allows for selective deprotection and disulfide bond formation on-resin in one step.

Two selected publications were summarized in this article in order to highlight the impressive utility of amino acids incorporating the diazirine photophore.

9 - 11 October 2019

9 - 11 October 2019

17 - 18 September 2019

8 - 12 September 2019

8 - 13 September 2019

5 - 7 September 2019

28 - 30 August 2019

3 - 5 July 2019

17 - 20 June 2019

22 - 27 June 2019

3 - 6 June 2019

12 - 16 May 2019

24 - 25 April 2019

9 - 11 April 2019

Protease inhibitors are molecules that inhibit protease function by binding either reversibly or irreversibly to the enzyme.

Methods for proteomic mapping of cellular organelles or subdomains that avoid the necessity of cell lysis and purification by targeting specific subcellular regions have several advantages.

18 - 21 March 2019

28 February - 1st March 2019

20 - 24 February 2019

3 - 7 December 2018

o -Nitroveratryloxycarbonyl (Nvoc) is a photocleavable side chain protecting group for lysine that can be removed by irradiation with UV light (350 nm).

Succinylation of proteins on the epsilon-amino group of lysine residues is a posttranslational modification that is still poorly understood.

8 – 10 November 2018

09 – 11 October 2018

10 – 12 October 2018

Find below derivatives of arginine and lysine bearing side chains as found in Maillard reaction products.

10-13 September 2018

Indocyanine Green (ICG) dye, a material approved by the FDA for various applications, is a powerful tool for imaging in live cells and tissues .

September 2 - 4, 2018

August 26-31, 2018

July 4-6, 2018

The 2D monolayer cell culture model is widely applied for drug screening. However, this approach is frequently not able to adequately mimic the in vivo response.

June 7-9, 2018 Aula Magna Partenope, Centro Congressi “Federico II” Naples, Italy

5 June 2018 Hotel Crowne Plaza Maastricht, The Netherlands

June 4-7, 2018 Boston, MA

Phosphorylation of serine, threonine and tyrosine is counted among the most important posttranslational modifications that occur in organisms.

We are proud to announce the relocation of our company to a brand new office and warehouse complex on May 17th.

Iris Biotech introduces a comprehensive set of photo-crosslinking amino acids bearing the diazirine moiety.

28-30 May 2018

The most common reagent for the Fmoc-protection of amino acids is currently Fmoc-OSu, followed by Fmoc-Cl. However, the use of these reagents is usually accompanied by several side reactions, such as the formation of beta-alanine and dipeptides.

The use of bioactive peptides has increased over the recent years as they attracted attention for their use as therapeutic agents.

May 7-10, 2018

16-17 April 2018

5-7 March 2018

February 28th – March 1st, 2018

5-7 February 2018

You can order via email, fax, our website, or telephone. If you are a new customer, we would like to ask you to use the order function of our webshop for your first order and to fill in all necessary fields of the form during checkout. Email: info@iris-biotech.de For orders: orders@iris-biotech.de Fax number for orders: +49 (0) 9231 97121-99

You can pay by bank transfer. US customers can pay by credit card (Visa, Master).

Of course, Iris Biotech is aiming to deliver your products as fast as possible. The following table provides an overview of general delivery times for products which are on stock and are not counted as dangerous goods. Stock Items Delivery Destination Germany Europe Worldwide Delivery Time 1 Day 1-2 Days Around 2-5 Days Although smaller quantities of dangerous goods can often be delivered just as fast as substances that are not declare...

Iris Biotech is working with qualified and reliable logistic partners. As various factors are influencing freight costs, the following information is only to be understood as approximate values. ≤ 1kg* Delivery Destination Germany Europe Worldwide Costs 20,00 EUR 25,00 EUR Please inquire Delivery Time 1 Day 1-2 Days Around 2-5 Days * Dangerous goods excluded. Prices are subject to changes. > 1kg* ...

We are pleased to send you a free copy of our catalogue or brochures free of charge. Furthermore, pdf downloads of our catalogue, the brochures, and various flyers are available on our Homepage.

Polyarginines are well known for their ability to enhance cell penetration.

Pacifico Yokohama, Japan Asia's Premier Partnering Event for the Global Biotechnology Industry BioJapan has played an important role in facilitating interaction between Japanese and global companies/organizations and stimulating new business opportunities. The Japanese and global biotechnology industry's top business development professionals, R&D personnel and biotech company executives will gather in Yokohama for the 19th BioJapan. We are looking forward to meet you there. Link: http://www.ics-exp...

The Fmoc group is the most frequently used protecting group in peptide chemistry. The most common deprotection conditions involve a solution of 20% piperidine in DMF.

Poly-(α-L-glutamic acid) is a synthetic polypeptide of L-Glu linked by the alpha-amino groups (α-PGA). These polyanionic and biodegradable polymers can be used for a variety of purposes.

Amino acids of high quality are crucial for the synthesis of peptides with a high purity.

Polylysines are polymers of the canonical amino acid Lysine, and are characterized by their high charge density caused by the presence of one free amino group per lysine monomer.

10 - 11 August 2017

5 - 7 July 2017

25 - 28 June 2017

19 - 22 June 2017

17 - 22 June 2017

This meeting intends to cover the various aspects of peptide-, protein chemistry as well as drug discovery and development, pharmacology, and structure-activity relationships. The meeting will take place on 08th June 2017 in Auditorium TU/e, Eindhoven, The Netherlands

24 - 25/04/2017

26 - 30/03/2017

20 - 23/03/2017

Mercapto-PEG-Acids are highly hydrophilic, non-antigenic, non-immunogenic and non-toxic.

a) Catalyst-free Click Reaction Cycloaddition reactions such as the [3+2] azide-alkyne and the [4+2] Diels-Alder reaction, are becoming common conjugation techniques. Applications range from imaging, drug design and development of sensors, thereby spanning the fields of chemical biology, material science, surface and polymer chemistry as well as many other fields. Introduced in 2002, the copper-catalyzed variant of the azide-alkyne cycloaddition (CuAAC) reaction has found broad applicability in t...

Mutant or modified aminoacyl tRNA synthetases (aaRS) have been used to charge non-natural amino acids to the corresponding tRNA, which incorporates them into polypeptides or proteins during recombinant synthesis.

As Boc and Fmoc protected derivatives of both azido and alkyne amino acids are available, they can be introduced into peptide sequences through standard SPPS protocols, for example. In an α-helical secondary structure amino acids at positions i and i+4 are above each other.

The azido group can be reduced to an amino function and hereby serve as masked amino group. It is of particular use if additional orthogonalities are needed. Azido is stable towards treatment with piperidine (Fmoc deprotection), Pd(0) (Alloc removal) and acidic treatmet (cleavage of Mtt, Trt or other acid sensitive groups). However, as it is a pseudohalogenide, care has to be taken during coupling steps, as HATU will cause high racemization. This can be avoided using collidine or other non-nucleophilic bas...

Protein and lipid glycosilation is a life-governing and omnipresent process. Glycoconjugates display a multitude of biological effects from protein folding and stabilization, energy storage, cell surface interaction through molecular recognition motifs for cell-cell communication, and structural support and protection.

Click Chemistry in DNA Synthesis - Applications and Procedures in DNA Synthesis

Diethyl-acetamidomalonate Route: The probably most widely used first approach to unnatural amino acids goes via alkylation of diethyl acetamidomalonate.

Several platforms are available to display the whole assortment of homo-amino acids, as well as the higher homologues β2-, β3-, their double substituted derivatives β2,2,2-, β3,3-, and corresponding γ-amino acids.

α-Methyl and alkyl-amino acids can be produced by a number of platforms, where the (2S,4S)-4-methyl-2-phenyloxazolidin-5-one scaffold is one of the most popular one.

Trypsin (EC 3.4.21.4), an endopeptidase and natural protease found in the digestive system, cleaves peptide chains and proteins predominantly at the carboxyl side of the amino acids Lys and Arg (except when followed by Pro).

The variations for linkers are endless, as in our catalogue program already hundreds of different derivatives are available for conjugation of small molecules, biomolecules and surfaces to each other.

Polyamines such as ethylene diamine and its higher homologues are important feedstocks for the chemical industry. Compounds like putrescine, spermidine, and spermine play important roles in both eukaryotic and prokaryotic cells and show many other different biological functions.

Proteins contained in meat and other comestible goods are usually rich in the amino acids arginine and lysine. The side chain func- tional groups of Arg and Lys react with reducing carbohydrates such as glucose or lactose to form Amadori reaction products.

The polymers in this context are a polymeric linear structures with n repeating units of monomers. Depending whether the polymer is consisting of one single molecular weight (only one n existing) or of a range of compounds with an average mass and a distribution of n around a mean value, polymers are referred to as “monodisperse” or “polydisperse”.

The polymers in this context are a polymeric linear structures with n repeating units of monomers. Depending whether the polymer is consisting of one single molecular weight (only one n existing) or of a range of compounds with an average mass and a distribution of n around a mean value, polymers are referred to as “monodisperse” or “polydisperse”.

Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have already been used as building blocks in polymer drug conjugates and polymeric micelles.

Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.

PEGs show a spectrum of unique physical and chemical properties, which have been described in literature extensively by the pioneers in PEGylation: Harris, Veronese and recently by Hermanson. Here are summarized the most common known properties.

Amino protected amino-PEG-acids can be used for the PEGylation of solid particles in order to create hydrophilic and reactive surfaces with no non-specific binding issues.

Nanotechnology and nanobiotechnology using gold or silver particles, quantum dots or even magnetic particles are broadly diverse, rapidly expanding areas of study in medical diagnostics and therapeutics, sensoric and chemistry.

The Biopharmaceuticals market, estimated at US$ 200 billion globally in 2013 by reportbuyer.com (Biopharmaceuticals - A Global Market Overview, 2013, London), is further projected to reach US$ 500 billion by 2020, growing at 13.5 % CAGR between 2010 and 2020.

Small drug molecules and also large biomolecules like proteins or antibodies suffer rapid clearance from human body.

Paolo Braiuca, Knapic Lorena, Valerio Ferrario, Cynthia Ebert, and Lucia Gardossi Adv. Synth. Catal. 2009; 351 : 1293–1302 https://doi.org/10.1002/adsc.200900009   Abstract: Computational techniques involving molecular modeling coupled with multivariate statistical analysis were used to evaluate and predict quantitatively the enantioselectivity of lipase B from Candida antarctica (CALB). In order to allow the mathematical and statistical processing of the experimental data largely ava...

Abstract: Ditrityl amino acids Trt-Lys(Trt)-OH (Trt = CPh3), Trt-Orn(Trt)-OH, Trt-Ser(Trt)-OH, and Trt-Hse(Trt)-OH were prepared and used in the synthesis of trityl-protected peptides, e.g., Trt-Ser(Trt)-Phe-NH2.

We now offer a series of Lysine dendrons for chemoselective functionalization of molecules containing carbonyl groups. These multivalent molecules carry diverse types of moieties, such as amine- or hydroxyl-groups, DOTA chelators or triphenylphosphonium (TPP) cations.

In this news section, we highlight three useful coupling reagents for peptide chemistry: PyCLOCK, PyAOP and HDMA.

Conjugates of PEG and folic acid or cholesterol, respectively, combine the positive properties of these molecules. Those conjugates are available with a wide variety of functional groups and different PEG chain lengths to suit your needs.

Fmoc-L-Dap(2-Boc-aminoethyl)-OH is the first in a series of new triamino acid building blocks. This azalysine is useful for introducing positive charges into a peptide, or for creating branched structures.

10-13 October 2016 San Diego, CA, USA Marriot Marquis & Marina

21-23 September 2016 Bangkok International Trade & Exhibition Centre (BITEC) 88th Bangna Trad Road, Bang Na, Bangkok 10260, Thailand

This innovative auxiliary facilitates Native Chemical Ligation at the position of a Glycine residue in a peptide sequence. The auxiliary can be further functionalized, e.g. by PEGylation. Following NCL, the auxiliary is removed by irradiation with UV light.

The classic FRET pair EDANS and DABCYL is now available linked to Fmoc amino acid building blocks that can be readily used in SPPS. Conveniently synthesize your own custom protease substrates!

Omniligase-1 enables efficient and racemization-free ligation of two side-chain unprotected peptide fragments at many different positions. Test this innovative enzyme developed by EnzyPep B.V. using the complementary model peptides included in our kit!

The SCAL linker offers superior chemical stability and permits a variety of orthogonal solid-phase approaches. It is fully compatible with the Fmoc-, Boc- and Alloc- strategies. Cleavage can be performed either by a simultaneous, or by a two-step reduction/acidolysis procedure to afford peptide amides.

Peptides as pharmaceutical compounds suffer from unfavorable pharmacokinetics which is, among other things, due to a slow uptake into cells and rapid proteolytic cleavage. N -Alkylation of peptides is a valuable tool to overcome these limitations. We now offer new kits that enable the facile preparation of peptoids and N -alkylated peptides.

The regioselective formation of multiple disulfide bonds is often a synthetic challenge. We now offer an innovative safety-catch Cys protecting group that allows selective deprotection of the sulfhydryl group and is a valuable addition to the peptide chemist’s toolbox.

June 6th - 8th, 2016 Moscone Center - South hall San Francisco, CA, USA

May 26-27,  2016 Hungarian Academy of Science Budapest, Hungary

May 23rd - 25th, 2016 Valencia, Spain The International Symposia on Polymer Therapeutics have become an excellent forum for the discussion of the latest developments in the emerging field of polymer therapeutics, emphasizing the importance of collaboration

The reaction between a tetrazine (Tz) and a trans -cyclooctene (TCO) is the innovative third generation Click reaction that proceeds without the use of copper or other catalyst. It is rapid, fully bioorthogonal and excels at very low concentrations.

Asymmetric Rhodamine 110 protease substrates are used for the determination of protease kinetics. The asymmetric structure of these dyes greatly simplifies the determination of enzyme kinetics, while the properties of Rhodamine 110 facilitate an uncomplicated readout.

Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.

Maillard Reaction Products (MRPs) result from the reaction of Arg and Lys side chains with reducing carbohydrates. MRPs are valuable markers for food quality and are used in many different branches of industry such as food, pharma, cosmetics and biochemistry.

April 18th-19th, 2016 London, UK Scientific discussions about the current results and future challenges of peptides research and therapeutics will be the main topic of this meeting.

Our new Biotin-SS-Tyramide linker is a valuable tool for peroxidase-promoted targeted protein biotinylation. By using peroxidase-tagged antibodies, proteins and protein clusters can be selectively biotinylated, and then isolated using streptavidin. The biotin tag can be subsequently removed using reducing agents (e.g. glutathione).

The Fmoc-L-Phe-Aca pseudo-dipeptide is a useful reporter group for the successful internalization of CPPs. Phe quenches the fluorescence of Aca. Internalization of the peptide containing Phe-Aca leads to proteolytic cleavage of the Phe-Aca bond and thus to fluorescence.

February 15th-17th, 2016 School of Pharmacie, Lille, France Iris Biotech GmbH will be present during the talks and supports the organisation with a booth at the Industrial Exhibition. We are pleased to get in personal contact with you.

We now offer  N,N' -Bis-Boc- N" -triflylguanidine , at both a very competitive price and our habitual high quality. Find out about the usefulness of this and our other guanylation reagents!

N δ -hydroxy- N δ -acetyl-ornithine, an important constituent of many siderophores, is now available for your convenience as  N α -Fmoc- N δ -(acetyl)- N δ -(benzoyloxy)-ornithine  building block which can be used in standard Fmoc/ t Bu SPPS and permits facile on-resin  N δ -deprotection.

5-oxa-Derivatives of Orn and Arg, respectively, these rare amino acids are produced by legumes as protection against herbivores. For your convenience, we offer building blocks of both amino acids compatible with standard Fmoc/ t Bu SPPS chemistry

Pre-packed amino acid cartridges for ABI peptide synthesizers are available for you convenience. Speed up your peptide syntheses with our cartridges containing all 20 standard amino acids for Fmoc/tBu chemistry.

Peptide linkers usually are cleaved under acidic conditions or using two-step procedures. Photocleavage proceeds under neutral conditions using UV light and can either be performed in batch or using flow chemistry.

Bulky glycine analogs are interesting molecules for creating peptide derivatives with certain biological activities, e.g. with antiviral properties. Furthermore, they are useful compounds for protein structure evaluation.

October 22 to 25, 2015 Ramada Couran Cove Island Resort, South Stradbroke Island, Queensland, Australia http://solidphase.org The symposium provides a superb opportunity for all practitioners of solid phase peptide synthesis together with those who use synthetic peptides for a myriad of applications to congregate at the beautiful Couran Cove Resort, South Stradbroke Island, a short ferry ride from the famed Gold Coast of Queensland .

October 25 to 30, 2015 Peppers Salt & Spa, Kingscliff, NSW, Australia http://www.ozpeptide.org/australian-peptide-conference-2015/australian-peptide-conference-2015/ In the 11th Australian Peptide Conference with typically some 200+ delegates the theme 'Peptide Discovery and Development' will address cutting edge areas of peptide and small protein research including: new bioactive peptides, advances in peptide and protein synthesis, target receptors and GPCRs, structure-based drug design, transc...

October 19 to 21, 2015 Sheraton San Diego Hotel & Marina, San Diego, CA, USA http://worldadc-usa.com More than 600 scientists from all over the world will gather for the leading conference in the field of Antibody Drug Conjugation . Learn how the industry’s best are innovating drug-linker chemistries to maximize efficacy and tolerability. Find new toxic molecules as potential payloads and see how Iris Biotech can support you with peptide and PEG based linker technologies.

Oligo-glycines are either flexible linkers or form well defined rigid substructures. We offer a variety of oligo-glycines as building blocks which can easily be introduced into any molecule.

Surprising behavior of NXO-peptides. It is a significant property of peptides that oxalo-retro azapeptides have the same donor and acceptor distances and properties for hydrogen bridge formation as a tripeptide fragment and therefore induce beta-sheet formation at this position.

A new hydrazone resin enables a convenient way to synthesize peptide hydrazides for Hydrazone Ligation Technique and Native Chemical Ligation (NCL).

September 20th - 23rd, 2015 Center for Interdisciplinary Research (ZiF), Bielefeld University, Germany The Center for Biotechnology (CeBiTec) of Bielefeld University cordially invites you to attend the 5 th International Bielefeld-CeBiTec Research Conference on "Drug Conjugates in Directed Therapy” . CeBiTec Research Conferences are annual events with thematic focus on a challenging topic in the life sciences. The 2015 conference " Drug Conjugates for Directed Therapy " is being organize...

August, 6th - 7th, 2015 Molecular Foundry, Lawrence Berkeley National Laboratory Berkeley, CA, USA The Peptoid Summit is a friendly gathering of students, post-docs, and PI’s investigating new directions in bio-inspired polymer research.  Peptoids are a highly designable polymer system, allowing unprecedented control over the their exact chemical structure.  This is leading to advances in a wide range of fields, from biomedicine to materials science.  Our community is growin...

July 1st - 3rd, 2015 Université d’Avignon et des Pays de Vaucluse Avignon, France RICT 2015 - the 51st edition of the International Conference on Medicinal Chemistry - is expected to gather 550-600 scientists from around the world, with a majority of scientists coming from Europe. The scientific programme, which will include over 25 plenary lectures by internationally well-known scientists, will focus on " Drug Discovery and Selection - Understanding Targets and Mechanisms ", coverin...

Alkylating the Nitrogen of an amide bond results in peptoid structures, leading to conformational restrains, like N-methylation and allows backbone derivatisation. Applications already have been published with Cilengitide, Piscidin 1, and MC4 receptor agonist.

May 17th - 22nd, 2015 Village Vacances of Portbail Portbail, Normandie, France The attractive program of the 19ème Congrès du GFPP will cover all aspects of contemporary peptide and protein sciences in both basic and applied domains. The conference program will include a general-public lecture, 13 cutting-edge plenary lectures, 28 selected oral communications, and several dozen posters and partner exhibition stands.

June 20th - 25th, 2015 Hyatt Regency Grand Cypress Orlando, FL, USA The topics of the 24th American Peptide Symposium are timely, and include biomarkers, bioactive peptides, synthetic methods, materials, macrocycles, epigenetics, metabolism, peptide medicinal chemistry, peptide therapeutics, formulation and delivery, as well peptide manufacturing. The program allows time for networking and checking out the latest technologies offered by the vendors.

June 15th - 18th, 2015 Pennsylvania Convention Center Philadelphia, PA, USA The BIO 2015 covers the wide spectrum of life science innovations and application areas. Drug discovery, biomanufacturing, genomics, biofuels, nanotechnology and cell therapy are just a few of the industries represented at the BIO International Convention. The four key elements of the event are: BIO Education Program Networking Events BIO One-on-One Partnering TM   BIO Exhibtion

June 10th - 12th, 2015 Reitoria of Universidade Nova de Lisboa Campus de Campolide, Lisboa, Portugal The 6th European Conference on Chemistry for Life Sciences (6th ECCLS) will be held in Lisbon, Portugal, in June 10-12, 2015. Lisbon meeting will be sixth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009), Budapest (2011) and Barcelona (2013) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge between chemi...

We at Iris Biotech, are pleased to announce that we have entered into an agreement with Peptide Solutions, LLC to sell the complete line of our products in the USA and Canada. Peptide Solutions’ website has a link to our complete list of products so ordering online is extremely easy, however, personal contact is available at the phone listed above, Monday through Friday, 8am to 5pm MST.

May 27th, 2015 Radboud University Nijmegen, The Netherlands The annual Dutch Peptide Symposium provides a unique opportunity for academic and industrial researchers working in the fields of peptide-, protein-, and amino acid chemistry to meet and exchange ideas, insights, and expertise. The 2015 edition of the Dutch Peptide Symposium will be held in Nijmegen on May 27.

June 9th - 12th, 2015 Palais Universitaire Strasbourg, France The use of biophysical techniques in drug discovery is rapidly increasing, and many pharmaceutical companies have set up in-house biophysical platforms to speed up the target-to-candidate process and improve the quality of small-molecule therapeutics through a better understanding of their interactions with their targets. The 2nd NovAliX Conference Biophysics in Drug Discovery 2015 intends to further develop the synergy between bi...

Wang resins are widely used for peptide synthesis. However, certain side reactions, like diketopiperazin formation limit their use. 4-Methylbenzhydryl resin needs more space and leaves less room for this type of side reactions. Standard “Wang-typical” Fmoc/tBu coupling protocols can be applied.

Pseudoprolines derived from Serine and Threonine have developed to standard building blocks for peptide synthesis since their invention. Now this technology is also available with Cysteine residues, as the corresponding 2,4-dimethoxyphenyl-pseudothiaproline is compatible with standard Fmoc/tBu protocols.

Aldehydes are between alcohols and carboxylic acids with respect to their oxidation level and show specific reactivity. Therefore they are highly interesting building blocks and intermediates for a large number of very interesting classes of reactions and compounds such as Wittig reaction, formation of secondary alcohols, heterocycles and semiaminals to name only a few.

  March 11th-12th, 2015 Technische Universität München Garching, Germany Latest findings and developments in the life sciences and their implementation in innovative technologies and new products in areas such as pharmaceutics, food and biotechnology will be at the focus of the 9th International Congress 'Forum Life Science' on 11-12 March 2015 at the Technische Universität Munich in Garching.

March 9th-11th, 2015 Porte de Versailles, Conference Center Expo Paris, France As the springtime counterpart to BIO-Europe, BIO-Europe Spring ® continues the tradition of providing life science companies with high caliber partnering opportunities. Featuring EBD Group’s acclaimed partnering system, partneringONE ® , the event enables delegates to efficiently identify, meet and get partnerships started with companies across the biotech value chain. In addition to productive part...

February 10th, 2015 DECHEMA-Haus Frankfurt/Main, Germany   The one-day symposium, organised by the DECHEMA working group on novel bio-production systems, will focus on recent advancements in the production and the application of these artificial proteins.

Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.

Cleavable dipeptide linkers like Val-Ala and Val-Cit rely on processes inside the cell to liberate the payload, as they undergo rapid hydrolysis in the presence of lysosomal extracts or purified human cathepsin B.

This oNv (2-Nitroveratryl) is the latest addition to our repertoire of cysteine protecting groups. It opens new possibilities of orthogonality to the existing strategies for disulfide bridge formation.

Many efforts have been undertaken to develop possibilities for copper-free Diels-Alder reaction based conjugation. Very promising options are Tetrazines and appropriate Dienophiles, as they are patent free and have potential for affordable bulk application.

February 4th-6th, 2015 Paris Biocitech, France Iris Biotech GmbH will be present during the talks and supports the organisation with a booth at the Industrial Exhibition. We are pleased to get in personal contact with you.

Maleimide (MAL) reacts rather specific with free thiol groups and forms appropriate conjugates. However, this reaction is slightly reversible, resulting in loss of the conjugation partner. Amino functions open the maleimido ring structure through hydrolysis with nucleophilc neighboring effect and thus inhibit the undesired release reaction.

Aminoisobutyric acid (Aib) and its homologues are a strong helix promoters in peptide mimetics. Aib-containing model peptides are already used in cancer treatment, antimicrobial peptides and cell penetrating peptides (CPP). We offer Aib and its homologues positioning the dimethyl fragment either close to the N- or to the C-terminus.

For introducing amino-PEG-acids into a peptide chain, several affordable building blocks are available with all conventional protecting groups. They can be incorporated at any sequence position by standard coupling protocols.

alpha-Sulfo-beta-Alanine has been used to couple to hydrophobic molecules and peptides and increase solubility. Attachment can be carried out by conventional Fmoc/tBu protocols.

November 21st, 2014 Llyod Conference Room, UCB Pharma Braine-L'Alleud, Belgium The Medicinal Chemistry Divisions of the two Belgian Chemical Societies, Société Royale de Chimie (SRC) and the Koninklijke Vlaamse Chemische Vereniging (KVCV), are organising every year an international one day symposium in Belgium, with the aim to update participants on selected areas of pharmaceutical research by specialists in their respective field. MedChem 2014 , with six invited lectures and three...

October 15th - 17th, 2014 Pacifico Yokohama Japan BioJapan has played an important role in facilitating interaction between Japanese and global companies/organizations and stimulating new business opportunities. The Japanese and global biotechnology industry's top business development and licensing professionals, alliance management professionals, R&D personnel and biotech company executives will gather in Yokohama for the 16th BioJapan .

September 22nd - 24th, 2014 St. Julien Hotel & Spa Boulder, CO USA ABOUT THE BOULDER PEPTIDE SYMPOSIUM The Boulder Peptide Symposium seeks to bring together key decision leaders from both industry and academia to discuss the future of peptide therapeutics. Peptide therapeutics are potent and highly selective yet their development into effective treatments can be challenged by limited delivery routes, product stability, manufacturing challenges and an evolving regulatory landscape. BPS is the ke...

1,4-substituted 1,2,3-triazole are isosteric to peptide bonds and result in peptide mimetics which even retain activity e.g. in case of certain tyrosinease inhibitors. We offer custom synthesis of Alkyne Amino Acid Analogues as building blocks for triazol formation via Click conjugation. Side chains can represent all natural amino acids or unusual residues. In combination with our alpha-azido acids we can offer the whole range of building blocks to design Click-peptide bond analogues for every proteinoge...

August 31st - September 5th, 2014 National Palace of Culture Sofia, Bulgaria The 33 rd European Peptide Symposium will provide a great opportunity to exchange ideas and to create new collaborations between successful scientists working in the field of Chemistry, Biology and Pharmaceutical industry related to Peptide Science. The event will offer a varied scientific program, including young scientists’ mini symposium, poster sessions, industrial exhibitions and attractive social program.

The presence of catalytic copper, limits the in vivo application of the Click this reaction for several reasons. We offer custom synthesis of Strained Cyclooctynes and Substituted 1,2,4,5- Tetrazines as building blocks for fast Click reactions in the absence of any catalyst.

GABA is a neurotransmitter in the central nervous system of mammals and its deficiency is associated with severe neurological disorders. Statine, a GABA analogue, occurs in several peptide APIs. Derivatives of gamma-amino acid analogues are of continued vital interest for a variety of applications in medicinal chemistry. We have a tool box available to offer a broad range of substituted gamma-amino acids and statines on custom synthesis basis.

September 10th - 12th, 2014 LITEXPO, Vilnius Vilnius, Lithuania Life Sciences Baltics 2014 is the only international forum in the Baltics for world-class biotechnology, pharmaceutical and medical devices experts from all around the world. It provides a unique opportunity to explore the new horizons of partnerships, exchange ideas and seek progress through networking. Discover enormous potential and passion in the field of life sciences in Lithuania and the Baltics – the gateway to emerging market...

Used for Efficient and Economic Bulk Synthesis of Peptide APIs: A new technology is available with a set of new preloaded resins, which enable the synthesis of peptide amides WITHOUT ANY LINKER. Amino acid amides, which bear a functional side chain, are immobilized on acid sensitive resins. This makes process development, small scale synthesis, bulk production and in-process control very easy. Find more technical details in our application for demonstration purposes with BIVALIRUDIN.

Benzotriazol activated carboxylic acids: Fast reaction (within minutes) at room temperature with amines and other nucleophiles under addition of base (in both water and non- aqueous solvents). Stable to racemization when coupling with nucleophiles. High solubility in organic solvents like DMF and DCM. Stable in water.

In modern biotechnology there are numerous applications for the luminogenic luciferase assay. We supply luciferin from mg scale for research applications like monitoring of gene expression or tumor growth up to kg quantities for hygiene surveillance in food industry

Novel liposomes built of dPEG-Phospholipids with defined PEG chain length provide prolonged blood-circulation time and improved cellular uptake as administration carriers for drugs, delivering active molecules to the desired target.

July 2nd - 4th, 2014 Rouen’s Law Faculty Rouen, Normandy, France The “Golden Jubilee” of the “Rencontres Internationales de Chimie Thérapeutique” (RICT) will focus on “Interfacing Chemical Biology and Drug Discovery” . Chemical Biology can be defined as the use of chemical tools to unravel biological processes. The chemical approach to Biology may not only contribute a quantitative framework for the description (and prediction!) of complex biological ev...

June 12th - 14th, 2014 Centro Congressi of University of Naples "Frederico II" Napoli, Italy The Workshop, designed to provide updated information and to critically discuss current trends on synthetic and conformational aspects of bioactive peptides, will deal in the 14th edition with the general subject: "The Renaissance era of Pepitdes in Drug Discovery" .

May 28th - 30th, 2014 KINTEX, Exhibition Center II Kintex, Korea BIO KOREA 2014 Conference is a worldwide accepted venue and place to discuss and acquire the cutting edge knowledge on various topics including vaccines, clinical trials, regenerative medicine, bio energy, GMO, functional food, technology transfer and licensing to firmly secure the global competitiveness.

Arginine rich peptides show increased interest during the last years as they have the capability to cross cell and blood brain barrier membranes.

Arginine rich peptides show increased interest during the last years as the have the capability to cross cell and blood brain barrier membranes.

Click chemistry has developed to a widely used conjugation technique. Here are our latest developments of new short linker for hydrophilic and hydrophobic applications.

May 19th - 21th, 2014 Centro de Investigación Príncipe Felipe Valencia, Spain Unlike other Drug Delivery Symposia that have a broader remit, this unique conference series was specifically established to provide a forum for interdisciplinary exchange of state-of-the-art techniques and advances in knowledge relating to the design, clinical development and commercialisation of Polymer Therapeutics. The key topics discussed during the 10th International Symposium on Polymer Therapeutics are...

Cysteins and homocysteins are found in many natural and artificial peptide sequences. Mercaptoproline is a rigid analogue of homocysteine offering several options to the medicinal chemist.

For most of our products Safety Data Sheets are available online now. Find them in five languages: English / French / German / Spanish / Czech . Simply log in to your account on our webpage and find them on the product description pages.

April 1st - 4th, 2014 Messe München Germany For four decades, analytica has been the leading international fair for state-of-the-art laboratory technology and pioneering biotechnology . No other trade fair in the world covers the range of subjects to do with the laboratory in industry and science in such breadth and depth, and on such a scale.

Tyramine compounds are converted to highly reactive radicals by horseradish peroxidase in presence of H2O2 which preferentially react with surface exposed tyrosines. Biotin Tyramide and Biotin-PEG-Tyramide therefore are ideal reagents used for tyrosine-/protein-biotinylation.

March 27th - 29th, 2014 Mosbach/Baden Germany The spring meetings of the German Society for Biochemistry and Molecular Biology (GBM) are held annually in the picturesque town of Mosbach to promote the exchange of scientific ideas and education of young scientists. The scientific theme of the 65th meeting is “Molecular quality control of proteins in health and disease”.

Phthalimidooxy PEG-based cross linkers form stable oximes with aldehydes, also latent ones as present in carbohydrates. Their reactivity is sufficiently mild for a broad used in creating conjugates with sensitive biologics.

Prolines are key elements positioned at the edge of β-turns in peptides. With modified prolines these positions can be used for either covalent amide or disulfide bonds – as we have demonstrated in many examples – or for filling hydrophobic pockets, whenever the pyrrolidine ring is substituted with groups like Methyl or Phenyl.

Superior Performance at a Sensational Price! Available as –COOH, -NHS, -Maleimide, -Alkyne, -Azide Half the price of other well-known dyes like Alexa- & Cy-Dyes. Available also in large quantities. Broadly applied in cell imaging, FRET, fluorescence quenching.

March 24th-25th, 2014 Montpellier, France Iris Biotech GmbH will be present during the talks and supports the organisation with a booth at the Industrial Exhibition. We are pleased to get in personal contact with you.

Compounds like putrescine, spermidine, and spermine play important roles in a many biological functions. Many of them are excellent targets for oncology studies and other fields of medicinal chemistry. Find in our new brochure Diamines & Polyamines our possibilities for custom synthesis and a set over 100 available derivatives.

January 22nd - 23rd, 2013 DECHEMA-Haus Frankfurt am Main, Germany The organizing committee cordially invites you to the 8th Status Seminar on Chemical Biology which will present cutting-edge research at the prolific interface of chemistry and biology.

Cfm Oskar Tropitzsch and Iris Biotech GmbH attended the China Hi-Tech-Fair (Nov 16-21, 2013) in Shenzhen. The Bavarian companies presented the latest stage of the art products in the field of peptides, life sciences research and drug discovery.

DTNB, frequently called Ellman’s Reagent, used as reagent for determination of free sulfhydryl groups.

Resin especially designed for the synthesis of long and difficult peptide sequences!

November 13th, 2013 Rudolf-Virchov-Zentrum Würzburg, Germany Iris Biotech GmbH nimmt am 6. Kooperationsforum Drug Developement - Targets-Design-Screening-  teil, wo über neuste Technologien und aktuelle Konzepte der Arzneimittelentwicklung zu informiert wird.

November 22nd, 2013 Beerse, Belgium MedChem 2013 - Constrained Peptides and Macrocycles – New Opportunities for Drug Discovery Annual One-Day Meeting on Medicinal Chemistry of KVCV & SRC

April 22-25, 2013 McCormick Place, Chicago, Illinois Iris Biotech GmbH will participate at the international Bio Convention 2013 in Chicago, USA. We would be glad to meet you.

June 22nd– 27th, 2013 Hilton Waikoloa Village Hawai‘i, USA The Symposium will follow its long standing tradition of featuring talks by leading scientists from the academic and industry communities sharing current and compelling peptide research.

October 9th-11th, 2013 Yokohama, Japan Meet our CEO and Mrs. Annick Vancolen and discuss the latest trends and ideas at our booth. Additional we will take part in the partnering and are looking forward to meet you.

October 22th-24th, 2013 Frankfurt/Main, Germany CPhI Worldwide 2013 is the best place to network with the global pharmaceutical community, source new suppliers, build relationships with existing partners and identify new business opportunities.

May 26th - 31st, 2013 Le Lazaret Sète, France Iris Biotech GmbH will be present during the talks and supports the organisation with a booth at the exhibition. We are pleased to get in personal contact with you.

Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet  et al . as versatile photoaffinity labeling agents to probe biological receptors.

June 18th-19th, 2013 Newmarket Racecourse Conference Centre, Cambridge, UK This 2-day conference and exhibition will feature top-level papers from industry and academia enabling delegates to learn how they can improve their research and development in the areas of peptide discovery, development, manufacture and application.

Long-chain acylcarnitines are well-known intermediates in mitochondrial fatty acid oxidation

The azido function can be used for different applications

Building Blocks for the synthesis of 2,3-diaminobutanoic acid containing peptides or for Click reactions.

October 10th-12th, 2012 Yokohama, Japan Meet our CEO and Mrs. Annick Vancolen and discuss the latest trends and ideas at our booth. Additional we will take part in the partnering and are looking forward to meet you.

October 9th-11th, 2012 Feria de Madrid, Spain CPhI Worldwide 2012 is the best place to network with the global pharmaceutical community, source new suppliers, build relationships with existing partners and identify new business opportunities.

The overall goal of our research is to capitalize on peptides of natural origin and their biological activity and chemistry.

September 2nd - 7th, 2012 Athens, Greece Megaron Conference Centre   With more than 550 submitted abstracts and more than 500 already registered participants coming from more than 40 different countries, the 32nd European Peptide Symposium assures an exciting scientific program.

July 15th - 20th, 2012 Leuven, Belgium The BOSS-conference is a unique international symposium as it combines lectures delivered by established organic chemists as well as younger rising stars with two prestigious events: a lecture delivered by the recipient of the “Janssen Pharmaceutica Prize for Creativity in Organic Synthesis”, and the “Tetrahedron Chair”: a one-day course on a specific topic in organic synthesis. Prof. Erick M. Carreira (ETH Zürich) has accep...

July 04th-06th, 2012 Poitiers, France This major international symposium will gather more than 450 scientists from around the world at the Faculty of Medicine and Pharmacy in Poitiers. The scientific programme, which will include over 25 plenary lectures by internationally well-known scientists, focuses on "Interfacing Chemical Biology and Drug Discovery", covering the main stages of modern drug discovery.

June 18th-21st, 2012 Boston, USA Iris Biotech GmbH will participate at the international Bio Convention 2012 in Boston, USA. We would be glad to meet you at our booth number 0828.  

June 07th-10th, 2012 Naples, Italy The Workshop, designed to provide updated information and to critically discuss current trends on synthetic and conformational aspects of bioactive peptides, will deal in the 13th edition with the general topic: “Conformation and Activity in Peptides: Relationships and Interactions” .

May 28th-30th, 2012 Valencia, Spain From Laboratory to Clinical Practice For details on the meeting please follow this link to the official website of CIPF

April 17th - 18th, 2012 Cambridge, UK The Peptide Conference will take place in conjunction with our new Dynamic Outsourcing for Life Sciences (DOLS) event, which will add extra value to your participation.

April 2-3 rd, 2012 CRDP - Montpellier, France An International Symposium dedicated to Prolines and derivatives organized under the auspices of the GFPP Iris Biotech GmbH will be present during the talks and supports the organisation with a booth at the Industrial Exhibition. We are pleased to get in personal contact with you.

March, 29th - 31th, 2012 Mosbach, Germany Once again outstanding scientists will present their work focussed on Posttranslational Modifications at the Mosbacher Kolloquium. Under the headline "Post-translational modifications in signal integration and molecular Therapies" the Kollogium will be an interesting event.

Spermines and other Biogenic Polyamines interact due to their multi cationic structure with DNA!

Properties of the MiDye Chromophore System: Readily applicable to biolabelling, Click  conjugation protocols and peptide synthesis Stable under buffer conditions (pH 4-8)  and in solid phase peptide synthesis Broadly applied in cell und animal  imaging, tested in FRET systems Available in larger quantities compared  to e.g. Alexa, Cy-Dyes etc. Purities > 85%, supplied as freeze-dried solid powder

February 12 th - 15 th , 2012 Dubai, UAE This unique international conference provides a platform for all pharmaceutical scientists, internists and primary care physicians to discuss and learn about all the important international breakthrough developments in drug discovery and on new therapeutics.

February 9th - 10th, 2012 Brussels, Belgium Since many years, the Belgian academic and industrial groups that are active in various aspects of peptide research did not have an opportunity to get to know each other and to discuss common interests.

Our portfolio currently contains over 5500 products. Many of them – in particular standard consumables for peptide synthesis – are being produced in bulk quantities.  Therefore we can keep our prices also for lab quantities at very competitive level. In case of need for bulk quantities please inquire: - All 20 Proteinogenic  Fmoc-protected Amino Acids  are available in 100+ kg Lots;

H-L-Aha-OH*HCl H-L-Dab(N3)-OH 4-Azido-L-homoalanine (S)-2-Amino-4-azidobutanoic acid hydrochloride Formula:                    C 4 H 8 N 4 O 2 *HCl Molecular Weight:     144,13*35,45 g/mole CAS:  942518-29-8 CODE:  HAA5730 1g:       EUR    200,-    US$    300,-  5g:   ...

Mal-AMCHC-OSu trans-N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate Formula:                    C 16 H 18 N 2 O 6 Molecular Weight:     334,33 g/mole CAS:  64987-85-5 CODE:  MAA1000 1g:       EUR    300,-    US$   420,- 5g:       EUR  1200,-  ...

Cleland's reagent, also known as dithiothreitol or DTT is a water soluble protective reagent for sulfhydryl groups. It reduces disulfide linkages to free sulfhydryl groups in proteins and enzymes. It is a component of buffers used in protocols for the isolation and purification of proteins. DTT (racemic), Cleland's Reagent

Reported applications: Introduction of 9-fluorenylmethyloxycarbonyl, trichloroethoxycarbonyl, and benzyloxycarbonyl amine protecting groups into O-unprotected hydroxylamino acids using succinimidyl carbonates; Anelka Paquet; Can. J. Chem. ; 1982; 60: 976. Widely Applicable Deprotection Method of 2,2,2-Trichloroethoxycarbonyl (Troc) Group Using Tetrabutylammonium Fluoride; Cheng-yuan Huanga; Ning Wanga; Katsumasa Fujikia; Yuji Otsukaa; Masao Akamatsua; Yukari Fujimotoa; Koichi Fukasea; Journal o...

Lipase B from Candida antarctica (EC 3.1.1.3) adsorbed on hydrophobic polymer Polystyrene DVB cross linked, 300-700µm, Synthetic Activity >10.000 U/g (dry),  very high mechanical stability - suitable for packed bed reactors

PGA (Penicillin G Amidase, Penicillin Acylase, Penicillin Amidohydrolase from E.coli on acrylic resin, Systematic name: Penicillin amidohydrolase, E.C. 3.5.1.11) has an active pocket, which is very specific for phenyl acetic acid. The prominent commercial use is hydrolysis of a phenylacetamid bond during production of the penicillin API 6-APA (De Martin et al., J. Mol. Catal. B:Enzymatic 1999; 6: 437). The high specifity of PGA towards the Phenylacetyl moiety makes the use of Phacm as new alternative ...

Dendrimers offer a new possibility to derivatize small molecules, surfaces or biopharmaceuticals with a monodisperse macromolecule and alter in this way properties like solubility and hydrophilicity. Immunogenicity and pharmacokinetics of pharmaceuticals will be improved. The synthetic approach for designing these dendrons of different generations is based on 2,2-bis(hydroxymethyl) propionic acid, which is a non-toxic and biocompatible building block. The size can be designed from 250 g/mole for 1st gene...

Ulf Hanefeld, Lucia Gardossi and Edmond Magner Chem. Soc. Rev. 2009; 38 :453–468; https://doi.org/10.1039/b711564b   Abstract:Enzymes are versatile catalysts in the laboratory and on an industrial scale. To broaden their applicability in the laboratory and to ensure their (re)use in manufacturing the stability of enzymes can often require improvement. Immobilisation can address the issue of enzymatic instability. Immobilisation can also help to enable the employment of enzymes in differe...

A novel, ethylene glycol-based protecting group is designed and synthesized for use in solid phase peptide synthesis.

Abstract: Trypsin digests peptides at the position of arginine. Because shorter homologues of arginine with appropriate protecting groups for conventional Fmoc/tBu peptide synthesis are now available, three model peptides containing arginine and two shorter homologues of arginine were synthesized.

Abstract: In 2006 the market of modern biopharmaceuticals has reached a volume of over 3 billion in USA and over billion world wide (IMS Health, Inc.).

Abstract: A considerable number of biologically active naturally occurring products are peptides, depsipeptides, and peptide conjugates.

Chiara Carboni, Hans G. T. Kierkels, Lucia Gardossi, Kamil Tamiola, Dick B. Janssen and Peter J. L. M. Quaedflieg Tetrahedron Asymmetry: 2006; 17 : 245–251 https://doi.org/10.1016/j.tetasy.2005.12.023     Abstract: We have demonstrated for the first time that D-glutamine (D-Gln) and D-glutamic acid (D-Glu) can be efficiently obtained in high ee (97% and 90%, respectively) by enzymatic kinetic resolution of D,L-Gln and D,L-Glu. This was achieved by enantioselective conversion of...

Peptides are key to modern drug discovery. This article reviews the requirements for bulk production of peptides and how it affects research and production of smaller scales.

Abstract: N alpha-9-Fluorenylmethoxycarbonyl-N epsilon-4=methyltrityl-lysine, [Fmoc-Lys(Mtt)-OH], was prepared in two steps from lysine, in 42% overall yield.