Search results for: 'glycine'

A Fluorescent Probe for “Hard and Soft” Reactive Metabolites

Discover CysGluDan, a new fluorescent probe for the detection of reactive metabolites in drug development, which can detect both "soft" and "hard" nucleophiles.

PotM: Oligomeric Sarcosine Building Blocks

You are looking for monodisperse Sarcosines ? You want to use Sarcosine for SPPS? You need to improve your drug's hydrophilicity and search for PEG alternatives? Read on!

Peptide Nucleic Acids as Stable DNA and RNA Analogs

One molecule, two identities: PNAs are composed of nucleobases arranged on a peptidic backbone. Discover our PNA building blocks as ready-to-use bases suitable for SPPS.

Fluorogenic Protease Substrates with Enhanced Signal-to-Noise-Ratio

Shine bright like our fluorophores! Learn how our superior fluorogenic protease substrate peptides can enhance your test performance. Click here to gather more information and discover available products!

PotM: Limited Offer - Polysarcosine Bundles

From beginning of May until end of July 2023 we offer special polysarcosine bundles each containing three functionalized PSars of different molecular weight (5 kDa, 10 kDa, 15 kDa), 100 mg each.

Workshop Polymer Therapeutics for Improved Drug Delivery

You missed our workshop featuring Prof. María Jesus Vicent Docón (Head of Polymer Therapeutics Lab)? Any further questions? Please get in contact via info@iris-biotech.de.

Sarcosine Building Blocks

Interested in the introduction of Sarcosine (N-methylglycine), e.g. for hydrophilicity increase of your derivative of choice or for PEG replacement? Check-out our available Sarcosine building blocks!

Conformationally Constrained Amino Acid Derivatives

Herein we present a series of alpha,alpha-cycle-disubstituted amino acid derivatives used in peptide design for their structure promoting effects as well as conformational rigidity.

PotM: Polysarcosines for Drug Delivery

Polysarcosines (PSars) – a true alternative to polyethyleneglycols (PEGs) - stand out in terms of safety, synthetic control, and versatility. Interested? Read on to find out more about their properties.

Workshop Prevention of Aspartimide Formation

You missed our workshop featuring Prof. Dr. Jeffrey W. Bode (ETH Zurich)? Any further questions? Please get in contact via info@iris-biotech.de

Measures to Prevent Aspartimide Formation

Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.

Cyclopropyl Modification

Cyclopropanes represent important design elements in medicinal chemistry and are widely present in drug compounds. Read on to find out more about their full potential.

Amino-Methylcoumarins as Fluorescent Labels

Enzymatically-activatable probes based on 7-amino-4-methylcoumarin (AMC) represent versatile tools for the detection and localization of proteolytic enzyme activities. Read on to find out more.

His-Tag for Specific Linker Attachment

Learn, how His-Tag can be used for specific linker attachment. Another example in our LINKEROLOGY series of sophisticated linker technologies.

Product of the Month: cyclo-Arg-Gly-Asp (RGD) Peptides

The integrin receptor interacting RGD sequence and related peptides act as promising tools for drug therapy and cancer research. Find more information on our portfolio of cyclic RGD peptides.

Betulins – Potent Natural Products

Betulin and its derivatives are pentacyclic triterpenoids of the lupane-type. They are natural products that occur as secondary metabolites in over 200 different plants. Betulinic acid (BA) is a derivative of betulin that is oxidized at C-28.

Specific platforms

Asymmetric Phase-Transfer Reaction Phase-transfer alkylations e.g. with the chiral Maruoka catalyst result in unique α-mono substituted and α,α-disubstituted unnatural amino acids.

Poly(Glutamic Acid) as Versatile Biodegradable Drug Carrier

Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have already been used as building blocks in polymer drug conjugates and polymeric micelles.

Polysarcosine – a True Alternative to PEG

Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.

Photocleavable NCL-Auxiliary Glycine

This innovative auxiliary facilitates Native Chemical Ligation at the position of a Glycine residue in a peptide sequence. The auxiliary can be further functionalized, e.g. by PEGylation. Following NCL, the auxiliary is removed by irradiation with UV light.

New Iris Kits for the Synthesis of Peptoids and N-Alkylated Peptides

Peptides as pharmaceutical compounds suffer from unfavorable pharmacokinetics which is, among other things, due to a slow uptake into cells and rapid proteolytic cleavage. N -Alkylation of peptides is a valuable tool to overcome these limitations. We now offer new kits that enable the facile preparation of peptoids and N -alkylated peptides.

Fast and Easy Protease Kinetics with Asymmetric Rhodamine 110 Substrates

Asymmetric Rhodamine 110 protease substrates are used for the determination of protease kinetics. The asymmetric structure of these dyes greatly simplifies the determination of enzyme kinetics, while the properties of Rhodamine 110 facilitate an uncomplicated readout.

Getting Bulky

Bulky glycine analogs are interesting molecules for creating peptide derivatives with certain biological activities, e.g. with antiviral properties. Furthermore, they are useful compounds for protein structure evaluation.

New: Guanidino-Glycine

Visit our Glycine section and find a series of amino acid derivatives, where oxazole is the characteristic structural element carrying carboxy and amino function.

New: Oxazole expanded Glycines

Visit our Glycine section and find a series of amino acid derivatives, where oxazole is the characteristic structural element carrying carboxy and amino function.

New: Oligo Glycine – Linker

Oligo-glycines are either flexible linkers or form well defined rigid substructures. We offer a variety of oligo-glycines as building blocks which can easily be introduced into any molecule.

Peptoids - Peptide Backbone Derivatisation

Alkylating the Nitrogen of an amide bond results in peptoid structures, leading to conformational restrains, like N-methylation and allows backbone derivatisation. Applications already have been published with Cilengitide, Piscidin 1, and MC4 receptor agonist.

New: Cysteine-Pseudoproline

Pseudoprolines derived from Serine and Threonine have developed to standard building blocks for peptide synthesis since their invention. Now this technology is also available with Cysteine residues, as the corresponding 2,4-dimethoxyphenyl-pseudothiaproline is compatible with standard Fmoc/tBu protocols.

Amino Aldehydes

Aldehydes are between alcohols and carboxylic acids with respect to their oxidation level and show specific reactivity. Therefore they are highly interesting building blocks and intermediates for a large number of very interesting classes of reactions and compounds such as Wittig reaction, formation of secondary alcohols, heterocycles and semiaminals to name only a few.

Improved Synthesis with Dmb-Glycine Dipeptide Building Blocks

Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.

Available Bulk

Our portfolio currently contains over 5500 products. Many of them – in particular standard consumables for peptide synthesis – are being produced in bulk quantities. Therefore we can keep our prices also for lab quantities at very competitive level. In case of need for bulk quantities please inquire: - All 20 Proteinogenic Fmoc-protected Amino Acids are available in 100+ kg Lots;