Search results for: 'linkerology'

HMPO: A pH-Responsive Linker for Targeted Drug Delivery

HMPO (5-(hydroxymethyl)pyrogallol orthoester), a plasma-stable, pH-sensitive, 1,6-self-immolative crosslinker derived from the natural product gallic acid. Discover its properties!

GGFG Motif for ADC Construction

To address both chemical and IP considerations in self-immolating linker applications , we propose shifting from the commonly used Val-Cit-PAB linker to the less explored Gly-Gly-Phe-Gly-formyl motif.

Interview with C&EN

Our CSO and VP Business Development Dr. Thomas Bruckdorfer had the pleasure to talk to C&EN about our linkerology platform.

Linkerology® for Targeted Delivery and Release

Use the possibilities of Linkerology® to boost the efficacy of your drug! We illustrate how the drug Gepirone (Exxua TM ), a medication to treat major depressive disorders, can be conjugated.

Phenylboronate Amino Acid Building Blocks

Boron is not boring at all! Today, we'll delve deeper into the exciting world of boronate-containing amino acid building blocks and unlock the potential of the next generation of peptides. Read on!

Linkerology® - An Example of Advanced Conjugation

The targeted delivery and traceless release of drugs is an important concept in pharmacology. Discover the possibilities of payload conjugation to carrier proteins shown for the example drug Elacestrant.

Review – Product Highlights 2023

Curious about the highlights of our 2023 portfolio additions? Discover innovative building blocks and latest technologies! Read on to check out the summary or get in contact if you need more details!

Combination Therapy & Linkerology®

Discover possibilities to fight chronic pain diseases by employing linker technologies. Check out the options for multiple drug conjugation in combination with different release mechanisms.

Linkerology® on Metal & Ore Surfaces

A heart of gold! Metals and ores - see here how their surfaces can be equipped with bifunctional organic linker molecules and thus be turned into modifiable biocompatible materials.

Workshop Bioorthogonal Chemistry in the Context of cell-free Protein Synthesis

You missed our workshop featuring Dr. Stefan Kubick (B4Pharmatech, Berlin)? Any further questions? Please get in contact via info@iris-biotech.de

Conjugating Small Molecule Drugs

You want to attach your small molecule to a certain carrier? Let’s analyze the functional groups present and discuss Linkerology® possibilities for permanent or trigger-inducible, tracelessly-cleavable linkage.

Cell-Free Bioengineering & Linkerology®

Bioengineering in combination with Linkerology® . Check out the unique options for membrane proteins, recombinant immunotoxins (RITs) and novel antibody-drug conjugates.

PotM: TCEP as Versatile Reducing Agent

TCEP is an effective reductant for disulfide bonds and a versatile reagent for various applications in protein science with distinct advantages compared to DTT and BME.

Conjugating Natural Products (3)

The potential of natural products of daily life , such as 6-shogaol from ginger ( Zingiber officinale) , can flourish if the active ingredient is conjugated to an appropriate carrier via Linkerology®.

Functionalization of Carbon Materials by Linker Attachment

Allotropes of carbon show distinct characteristics in structure and e.g. electric and biophysiological properties. Discover how these materials can be further exploited by linker attachment!

Review – Product Highlights 2023 (Part 1)

Curious about our latest portfolio additions from January to June 2023? Discover our New Products Flyer and check out the summary of recent product highlights! Get in contact for more details!

Functionalization of (Inert) Polymeric Surfaces

Plasma technology allows to equip inert polymers such as poly(ethylene) or polystyrene with functional groups like amine or carboxylate enabling further conjugations and applications. Read on!

Conjugating Natural Products (2)

Infinite like the deep sea – marine natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.

Conjugating Natural Products (1)

From evolution to solution - natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.

Maleimide Crosslinkers

Maleimides provide versatile options for connecting payloads to proteins and other biomolecules. Discover how our bifunctional thiol reactive crosslinkers can support your project. Read on!

Choose your Taste – Functionalized Halo/Snap/Clip Substrates

The HaloTag®, SNAP-Tag® and CLIP-Tag TM represent versatile tools for the specific, covalent attachment of in principle any molecule of choice to a protein of interest. Discover our substrates!

Let’s Talk Iris

You want to get an overview about the different Click technologies as well as available derivatives and applications? Let’s arrange a (virtual) talk by Iris Biotech about your topic of choice – Contact us!

Review – Product Highlights 2022

Curious about our latest portfolio additions from July to December 2022 and the 2022’s overall product and newsletter highlights? Click here to check out the summary or get in contact for more details!

Workshop Autocatalytic His Tags for the Chemical Modification of Proteins

You missed our workshop featuring Prof. Knud J. Jensen (Professor, Head of Group; University of Copenhagen)? Any further questions? Please get in contact via info@iris-biotech.de.

Linker Technologies for Sophisticated Bioconjugations

Linkers serve as versatile tools, e.g. during SPPS or for the sophisticated (self-immolative) conjugation of a potent small molecule to a carrier. Check out our selection of over 100 readily available linkers.

pH-Sensitive Self-Immolative Linkers

Are you active in the field of antibody drug conjugates? Click here to find out more about our selection of as well as the technology behind pH-sensitive self-immolative linkers.

Custom Synthesis Services at Iris Biotech

Iris Biotech is your trusted partner in the world of peptides and all related disciplines. Your project requires a compound not listed in our portfolio? Get in contact and inquire for a custom synthesis!

PotM: Proteolysis Targeting Chimeras (PROTACs®)

Drug the undruggable – click here to get more information about the use of PROteolysis TArgeting Chimeras (PROTACs®) as a tool for targeted protein degradation and discover available building blocks.

Review – Product Highlights 2021

Herein, we summarize certain product highlights and innovations, which we presented in our newsletters 2021. Have a look and get in contact for more information or an individualized offer.

Special Offer – Summary Advent Calendar

See a summary of our advent calendar surprises and benefit from special discounts and great offers! Interested? Just click here to check-out all available products.

Enzymatically Cleavable Linkers Based on Val-Cit and Val-Ala

The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.

PotM: Pyridyldithiols as Precursors for Disulfide-Based (Self-Immolative) Linkers

Read on to find out more about Iris Biotech’s Linkerology® portfolio including substituted pyridyldithiols as building blocks for the reversible chemical conjugation to sulfhydryls.

11th World ADC Europe 2021

March 8 - 11th, 2021

Cyclopropyl Modification

Cyclopropanes represent important design elements in medicinal chemistry and are widely present in drug compounds. Read on to find out more about their full potential.

Trimethyl Locks

The sterical interference of three closely positioned methyl groups favors amide cleavage and payload release upon lactonization. This cascade can be induced by various triggers. Read on to find out more.

PotM: Disulfide-Based Self-Immolative Linkers

The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.

Linkerology

Check out our latest video summarizing our capabilities and knowledge on linker technologies

Valine-Citrulline Based Enzymatically Cleavable Linkers

Iris Biotech presents its selection of Val-Cit-based linkers, a dipeptide motif frequently utilized for the development of ADCs with increased serum stability and high cleavage efficiency.

His-Tag for Specific Linker Attachment

Learn, how His-Tag can be used for specific linker attachment. Another example in our LINKEROLOGY series of sophisticated linker technologies.

Product of the Month: Dde-based Linkers

Placing Dde as one terminal group of a linker and a functional group prone for conjugation as the other or using Dde as the central connective portion of a linker, allows for the creation of new bifunctional linkers.

Subject Focus: Linkerology

The ever-growing sophistication and variation in linker design have given rise to a new and distinct field of knowledge in synthetic chemistry termed Linkerology. Discover our expertise and panoply of new cutting-edge tailor-made linker constructs for the latest state-of-the-art bioconjugations.