Search results for: 'poly lysine'

PotM: Versatile TentaGel® Resins

Discover the diversity of TentaGel® Resins ! Read our blog to get more information about our latest product additions and possible applications and find the right resin for your research endeavors!

Bioisosteric Argininine Analogs

Same but different! Expand your possibilities for peptide modification and fine-tuning by implementing N ω -carbamoylated arginine building blocks as bioisosteric arginine analogs.

Protecting Groups in SPPS

Mix & Match. Discover typically employed protecting groups used to temporarily mask reactive functional moieties during solid-phase peptide synthesis to prevent undesired side-reactions.

Norbornenes – Will You Click Me?

Proposing norbornenes – strained, bicyclic alkenes for fast, copper-free, biocompatible click-conjugation with tetrazines. Read on for more details on applications and available products!

A Tetrazole-Substituted Lysine as PTM Isostere

The tetrazole isostere of malonyllysine is thermally stable and does not suffer from decarboxylation. Discover our building blocks suitable for incorporation via solid-phase peptide synthesis.

Review – Product Highlights 2023

Curious about the highlights of our 2023 portfolio additions? Discover innovative building blocks and latest technologies! Read on to check out the summary or get in contact if you need more details!

Selective Lysine Labeling with Squaric Acid

Keeping control! PEGylating reagents with a squaric acid ethyl ester react chemoselectively with side chain amino functions of surface-accessible Lysines in proteins. Other functionalities are not affected.

Amino-PEG-Acids

PEGs are being used as spacers, as hydrophilic decoration, and building blocks. Read on for more detailed information about the reactivity of different PEG derivatives and how to use them.

PotM: Argpyrimidine Building Block for SPPS

Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!

Temporary Activity Masking via Self-Immolative Linkage

(Bi)functional dioxoborolane and disulfide-based self-immolative linkers – mode of action and application examples for the detection of H 2 O 2 , for prodrug design, and reversible peptide cyclization.

PotM: His Tags for the Chemical Modification of Peptides

Jensen et al. developed two methods that use poly-His sequences to direct the highly selective acylation of proteins, either at the N-terminus or at a specific Lys residue. Read on for more information.

Workshop Polymer Therapeutics for Improved Drug Delivery

You missed our workshop featuring Prof. María Jesus Vicent Docón (Head of Polymer Therapeutics Lab)? Any further questions? Please get in contact via info@iris-biotech.de.

Drug Delivery at Iris Biotech

Discover our products suitable for drug delivery including poly ethyleneglycols (PEGs), poly amino acids (PArg, PGlu, PLys, POR, PSar), poly(oxazoline)s, as well as fullerenes. Read on to find out more!

Hydrazone Resins as Alternative to SEA Resins

Discover the versatile applications of hydrazone resins e.g. for the preparation of peptide hydrazides, or the generation of peptide thio esters. Read on to find out more and see our available products.

Fmoc-L-Cys(Palm)-OH – A S-palmitoylated Cysteine building block

Interested in studying the effect of palmitoylation on your peptide’s localization, function, and stability? Read on to find out more about the use of lipidated “fatty” amino acids!

Product Focus: TT-232, a Potent Somatostatin Analogue

Amongst various somatostatin analogues, the pentacyclic heptapeptide TT-232 bears unique properties. Iris Biotech offers TT-232 as triacetate and trifluoroacetate salt, respectively, as well as conjugated to either biotin or the fluorophore indocyanine green.

Alkyne Amino Acids for Click Chemistry and other Conjugations:

Alkyne amino acids allow for Click conjugations and other types of chemistry. Read more about alkyne-functionalized amino acids and our related products.

Fmoc-L-Lys(Nvoc)-OH

o -Nitroveratryloxycarbonyl (Nvoc) is a photocleavable side chain protecting group for lysine that can be removed by irradiation with UV light (350 nm).

(TPP-Lys(TPP))2-Lys-Gly-Gly-Gly-N2H3*4Br*TFA

Delivery of hydrophilic compounds across membranes is usually problematic. Modification with triphenylphosphonium ions has been shown to overcome this barrier.

Polylysines

Polylysines are polymers of the canonical amino acid Lysine, and are characterized by their high charge density caused by the presence of one free amino group per lysine monomer.

Recombinant Incorporation of Amino Acids into Proteins

Mutant or modified aminoacyl tRNA synthetases (aaRS) have been used to charge non-natural amino acids to the corresponding tRNA, which incorporates them into polypeptides or proteins during recombinant synthesis.

Specific Linkers

The variations for linkers are endless, as in our catalogue program already hundreds of different derivatives are available for conjugation of small molecules, biomolecules and surfaces to each other.

Polysarcosine – a True Alternative to PEG

Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.

Poly(Ethylene Glycol) – the Pioneer in Polymer Therapeutics

PEGs show a spectrum of unique physical and chemical properties, which have been described in literature extensively by the pioneers in PEGylation: Harris, Veronese and recently by Hermanson. Here are summarized the most common known properties.

Lysine Dendrons

We now offer a series of Lysine dendrons for chemoselective functionalization of molecules containing carbonyl groups. These multivalent molecules carry diverse types of moieties, such as amine- or hydroxyl-groups, DOTA chelators or triphenylphosphonium (TPP) cations.

Click Chemistry Tools: Propargyl Amino Acids

Click chemistry is a convenient method to chemoselectively functionalize peptides at specific positions. We offer a variety of different propargyl amino acids for both Fmoc and Boc strategies, for enzymatic synthesis, as well as preloaded resins for SPPS.

Phthalimidooxy PEG-based cross linkers

Phthalimidooxy PEG-based cross linkers form stable oximes with aldehydes, also latent ones as present in carbohydrates. Their reactivity is sufficiently mild for a broad used in creating conjugates with sensitive biologics.