Search results for: 'protein'

Game Changer for Protein Modification: Discover oxidation-induced furan crosslinking and 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones ( 5HP2O s) as stable alternative to maleimides.

HMPO (5-(hydroxymethyl)pyrogallol orthoester), a plasma-stable, pH-sensitive, 1,6-self-immolative crosslinker derived from the natural product gallic acid. Discover its properties!

Discover MYTsA as coupling reagent for peptide synthesis in “traditional” C→N and vice versa in “natural” N→C direction. Avoid racemization and benefit of improved atom economy!

Collect information about the most common side reactions during Fmoc SPPS and how to avoid them! Choose your building blocks and conditions wisely to avoid unnecessary trouble!

Discover the diversity of TentaGel® Resins ! Read our blog to get more information about our latest product additions and possible applications and find the right resin for your research endeavors!

Where does life come from and how can we simulate early earth conditions leading to simple organic molecules such as nucleotides and amino acids, the building blocks of RNA and peptides?

Mix & Match. Discover typically employed protecting groups used to temporarily mask reactive functional moieties during solid-phase peptide synthesis to prevent undesired side-reactions.

What’s new? Don’t miss innovative building blocks and latest technologies – have a look at our new products flyer and discover our portfolio additions from January to June 2024!

Novel excipients can help you master the challenges associated with the production and formulation of protein- and RNA-based drugs due to their inherent fragility. Discover the SURPAX TM technology!

Encode beads with unique tags for combinatorial syntheses & screening. Build libraries & identify hits. Discover properties and applications of our novel bifunctional TentaGel® resins.

Wondering about the difference between Boc and Fmoc chemistry in solid phase peptide synthesis? Don't worry: in this short overview we will guide you through the basics of both strategies.

Proposing norbornenes – strained, bicyclic alkenes for fast, copper-free, biocompatible click-conjugation with tetrazines. Read on for more details on applications and available products!

Clever Move - Add positive effects to your molecule by introducing the most electronegative element. Discover fluorinated building blocks as game changer for your lead development. 

Level up! Carboxymethyl-modified amino acid building blocks suitable for incorporation by solid-phase peptide synthesis. Learn more about available derivatives and their properties.

Discover photocages – photosensitive protecting groups that are removed by irradiation with light of a defined wavelength, thus restoring the original, “active” state.

June 2-5, 2024

Have an additional ace up your sleeve for selective and efficient peptide modification, cyclization, and/or bioconjugation. Explore 2-cyanopyridines for click-like reactions. Get more information!

Beyond cysteines: Unlock targeted side-chain modifications of your peptides and proteins via the introduction of 1,2-aminothiols and subsequent click-like functionalization. 

Engineer shape-shifting peptides , controllable by a laser as magic wand! In this newsletter, we’ll explore the possibilities of photo switchable building blocks based on azobenzene.

You are looking for monodisperse Sarcosines ? You want to use Sarcosine for SPPS? You need to improve your drug's hydrophilicity and search for PEG alternatives? Read on!

The targeted delivery and traceless release of drugs is an important concept in pharmacology. Discover the possibilities of payload conjugation to carrier proteins shown for the example drug Elacestrant.

You are looking for a building block suitable to control the folding characteristics of your peptide or want to add a pH-sensitive conformational switch? Discover aminoprolines and their properties!

Are you keen on developing novel billion-dollar-selling peptide API blockbusters? Most recent ones use lipophilic Albumin binding moieties. Of course, Iris Biotech has the necessary building blocks!

The tetrazole isostere of malonyllysine is thermally stable and does not suffer from decarboxylation. Discover our building blocks suitable for incorporation via solid-phase peptide synthesis.

Increase your peptide’s stability, introduce an NMR label for analysis, or enhance lipophilicity. Read our blog to discover our latest toolbox additions in the field of non-canonical amino acids.

Curious about the highlights of our 2023 portfolio additions? Discover innovative building blocks and latest technologies! Read on to check out the summary or get in contact if you need more details!

Discover possibilities to fight chronic pain diseases by employing linker technologies. Check out the options for multiple drug conjugation in combination with different release mechanisms.

Add glycans to your proteins with our ready-to-use Fmoc asparagine building blocks suitable for solid phase peptide synthesis and produce peptides with exactly defined glycosylation patterns!

The discovery of the Merrifield peptide synthesis paved the way for automated solid-phase peptide synthesis (SPPS) enabling fast and convenient simultaneous peptide synthesis.

Sick of Lysine side chain protecting groups jumping around, yielding scrambled peptides? Check our various options to fine-tune protecting group stability vs. cleavability to optimize your peptide yield.

A heart of gold! Metals and ores - see here how their surfaces can be equipped with bifunctional organic linker molecules and thus be turned into modifiable biocompatible materials.

Keeping control! PEGylating reagents with a squaric acid ethyl ester react chemoselectively with side chain amino functions of surface-accessible Lysines in proteins. Other functionalities are not affected.

You missed our workshop featuring Dr. Stefan Kubick (B4Pharmatech, Berlin)? Any further questions? Please get in contact via info@iris-biotech.de  

Discover our new building block 4-(azido-propyl-tetrazine)phenylalanine (pTAF) and make use of the orthogonality of the 2 nd and 3 rd generation Click reaction to build multiconjugates via double-Click.

Bioengineering in combination with Linkerology® . Check out the unique options for membrane proteins, recombinant immunotoxins (RITs) and novel antibody-drug conjugates.

September 17 - 21, 2023

TCEP is an effective reductant for disulfide bonds and a versatile reagent for various applications in protein science with distinct advantages compared to DTT and BME.

Allotropes of carbon show distinct characteristics in structure and e.g. electric and biophysiological properties. Discover how these materials can be further exploited by linker attachment!

Discover the cyanobenzothiazole (CBT) click reaction , a not (yet) so well-known biocompatible and bio-orthogonal mechanism faster than the famous azide-alkyne cycloaddition (CuAAC).

Curious about our latest portfolio additions from January to June 2023? Discover our New Products Flyer and check out the summary of recent product highlights! Get in contact for more details!

Discover our diazirine-substituted building blocks suitable for the analysis of protein-protein and RNA-protein interactions via proximity labeling upon photoactivation. Read on for more information!

Plasma technology allows to equip inert polymers such as poly(ethylene) or polystyrene with functional groups like amine or carboxylate enabling further conjugations and applications. Read on!

You missed our workshop featuring Prof. Rob Liskamp (Cristal Therapeutics, University of Maastricht, University of Glasgow)? Any further questions? Please get in contact via info@iris-biotech.de.

Our building block Fmoc-L-Cys(Cam)-OH enables peptides resembling reduced and carbamido-methylated protein fragments by standard SPPS without error-prone modification reactions.

Plant-derived Cholesterol of high and consistent product quality in accordance with Pharmacopoeia requirements to replace established animal source material in LNP formulation. Read on!

Shine bright like our fluorophores! Learn how our superior fluorogenic protease substrate peptides can enhance your test performance. Click here to gather more information and discover available products!

Building blocks with a strained triple bond do not require copper catalysis when used in click chemistry. Discover CliCr®: improved solubility in aqueous conditions and high reactivity! Click here!

Peptide therapeutics – fewer injections/lower doses by prolonging their half-life via addition of a lipid modification that promotes binding to serum proteins such as albumin. Read on for recent innovations!

From beginning of May until end of July 2023 we offer special polysarcosine bundles each containing three functionalized PSars of different molecular weight (5 kDa, 10 kDa, 15 kDa), 100 mg each.

Our monofunctionalized dextrans are enriching the toolbox of polymer therapeutics – Dextrans benefit of excellent solubility, biocompatibility, biodegradability, and non-immunogenicity.

Non-canonical Tryptophan analogs can help to improve your API’s performance in terms of potency, specificity, and stability. We offer various substituted Trp derivatives also available in small quantities for screening.

You missed our workshop featuring Prof. Christian F. W. Becker (University of Vienna)? Any further questions? Please get in contact via info@iris-biotech.de.

Maleimides provide versatile options for connecting payloads to proteins and other biomolecules. Discover how our bifunctional thiol reactive crosslinkers can support your project. Read on!

Herein, we present functionalized perfluorobiphenyl building blocks which can be used for site-selective π -clamp mediated cysteine conjugation. Read on for more details about this general method!

PEGs are being used as spacers, as hydrophilic decoration, and building blocks. Read on for more detailed information about the reactivity of different PEG derivatives and how to use them.

Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!

The HaloTag®, SNAP-Tag® and CLIP-Tag TM represent versatile tools for the specific, covalent attachment of in principle any molecule of choice to a protein of interest. Discover our substrates!

(Bi)functional dioxoborolane and disulfide-based self-immolative linkers – mode of action and application examples for the detection of H 2 O 2 , for prodrug design, and reversible peptide cyclization.

Herein, we present CliCr® as an innovative cyclic alkyne for metal-free strain-promoted click chemistry. Read our blog for detailed information about CliCr® reagents based on TMTHSI and check out available derivatives!

Curious about our latest portfolio additions from July to December 2022 and the 2022’s overall product and newsletter highlights? Click here to check out the summary or get in contact for more details!

You missed our workshop featuring Prof. Knud J. Jensen (Professor, Head of Group; University of Copenhagen)? Any further questions? Please get in contact via info@iris-biotech.de.

We can’t get enough of new products and innovations! Read this blog to get detailed information on the cyanylating reagent NTCB as well as selenocysteine amino acids, both useful tools for peptide ligation.

Jensen et al. developed two methods that use poly-His sequences to direct the highly selective acylation of proteins, either at the N-terminus or at a specific Lys residue. Read on for more information.

Linkers serve as versatile tools, e.g. during SPPS or for the sophisticated (self-immolative) conjugation of a potent small molecule to a carrier. Check out our selection of over 100 readily available linkers.

The 2022 Chemistry Nobel prize is awarded to B. Sharpless, M. Meldal and C. Bertozzi for their work in the field of Click Chemistry. At Iris, we are providing clickable building blocks for nobel chemistry. Read on for more information!

The ChemMatrix® resin production and distribution was discontinued by its manufacturer SEQENS. Products are only available at Iris till current stock is sold out. Read on for more information!

You want to get an overview about the various resins available at Iris Biotech as well as their specifications, differences, and applications? Read on for further information and details.

Herein, we present 2-Iminobiotin, a cyclic guanidino analogue of biotin with pH-dependent affinity for avidin, and compare it to biotin and desthiobiotin. Click here for more detailed information.

The Dawson Linker and its variants provide access to C-terminal peptide thioesters which are crucial components of Native Chemical Ligation reactions. Read on to discover all derivatives available at Iris Biotech!

The para -azido benzyloxycarbonyl protected lysine building block Fmoc-L-Lys(4-N3-Z)-OH (FAA8830) is useful for a wide range of applications. Read on to find out more!

Photoswitches grant the ability to modulate the function of a molecule by effecting a structural change upon irradiation with UV light. Find out about our photoswitchable building blocks and their properties.

You missed our workshop featuring Prof. María Jesus Vicent Docón (Head of Polymer Therapeutics Lab)? Any further questions? Please get in contact via info@iris-biotech.de.

Dyes and fluorescent labels are an invaluable tool for diagnostics, medical and biochemical research. Iris Biotech offers labels with excitation ranges from UV to near-IR and various functional groups.

Discover our products suitable for drug delivery including poly ethyleneglycols (PEGs), poly amino acids (PArg, PGlu, PLys, POR, PSar), poly(oxazoline)s, as well as fullerenes. Read on to find out more!

Drug the undruggable – click here to get more information about the use of PROteolysis TArgeting Chimeras (PROTACs®) as a tool for targeted protein degradation and discover available building blocks.

Iris Biotech offers the main building blocks for the synthesis of Liraglutide and Semaglutide and commonly observed impurities as well as reference standards. Read on for more information!

We are providing variously functionalized, protected and unprotected fatty acid derivatives suitable for SPPS and further conjugation, e.g. via Click chemistry. Read on to discover our portfolio.

Oxidation is not only a known degradation pathway of proteins and peptides in vivo but is also a major side reaction for certain amino acids during peptide synthesis in vitro. Read on to discover our available building blocks.

Interested in polymers for the delivery of promising drug candidates, e.g. nucleic acids? Discover our selection of lipidated polyamino acids and custom capabilities. Read on to find out more!

Interested in the introduction of Sarcosine (N-methylglycine), e.g. for hydrophilicity increase of your derivative of choice or for PEG replacement? Check-out our available Sarcosine building blocks!

Herein, we present building blocks for the synthesis of protected hydroxylamine derivatives which can be further used for bio-conjugation and various other applications. Read on to find out more!

Discover our selection of propargyl-substituted amino acids and find the best position for subsequent Click chemistry within your peptide/protein. Just click here for further information on our products.

Stable isotopically labeled drugs are routinely used to investigate a drug’s metabolism, distribution, bioavailability, side effects and potential toxicity. Discover our selection of labeled drugs.

Discover our selection of substrates for Halo-, Snap-, and Clip-tagged proteins bearing different terminal groups suitable for further functionalization, e.g. biotinylation and Click chemistry.

Herein, we summarize certain product highlights and innovations, which we presented in our newsletters 2021. Have a look and get in contact for more information or an individualized offer.

Herein we present a series of alpha,alpha-cycle-disubstituted amino acid derivatives used in peptide design for their structure promoting effects as well as conformational rigidity.

Check out our growing portfolio on adamantyl-substituted amino acids and building blocks. At Iris Biotech, we are constantly striving to improve our services, our products, and the routes of synthesis.

Discover our selection of Halo ligands as haloalkane dehalogenase substrates, bearing different terminal functional groups suitable for further conjugation, e.g. via Click chemistry.

Polysarcosines (PSars) – a true alternative to polyethyleneglycols (PEGs) - stand out in terms of safety, synthetic control, and versatility. Interested? Read on to find out more about their properties.

Discover the versatile applications of hydrazone resins e.g. for the preparation of peptide hydrazides, or the generation of peptide thio esters. Read on to find out more and see our available products.

Selenocysteine (Sec) plays a crucial role for various biological processes, and selenoproteins can be found in all lineages of life. Read on to discover the 21 st amino acid, its derivatives and applications.

Read on for more information about the right handling of Maillard Reaction Products (MRPs), which are frequently used as analytical standards related to food quality and disease processes.

Herein we are presenting 2-(Fmoc-amino)-3,3-diMe-pent-4-enoic acid (FAA5040), a protease stable Ile/Leu surrogate suitable for further modification via its side chain double bond.

Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.

Iris Biotech offers a variety of (functionalized) biotin and desthiobiotin reagents reactive towards certain functional groups. Discover our growing portfolio and latest additions.

Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which can be elongated by Fmoc-SPPS and can easily be linked to amino-functionalized solid supports. Read on to find out more about their advantages.

Compounds of the shown formula can simply be bound to solid supports via amide bond formation without racemization of the C-terminal amino acid and enable the synthesis of very pure peptides.

The incorporation of alpha-trifluoromethyl substituted amino acids into peptides increases proteolytic stability, enhances lipophilicity, and induces secondary structures. Read on to find out more!

Interested in structure-activity studies of your Proline-containing peptide drug? Find out more about the use of Methanoprolines and Dimethylprolines as conformational amide locks.

With the approval of several COVID-19 vaccines and drugs in recent months, hope is growing that the current pandemic will end soon.

Iris Biotech offers various (protected) azide- and alkyne-modified fatty acid derivatives suitable for Click Chemistry. Interested? Read on to find out more!

Iris Biotech offers hetero-bifunctional crosslinkers bearing an N-hydroxysuccinimide (NHS) ester and a maleimide group suitable for the reaction with amine- and thiol-containing molecules.

Read on to find out more about Iris Biotech’s Linkerology® portfolio including substituted pyridyldithiols as building blocks for the reversible chemical conjugation to sulfhydryls.

You missed it? We are pleased to provide the full-length recording for your convenience! Any further questions? Please get in contact via info@iris-biotech.de!

Interested in studying the effect of palmitoylation on your peptide’s localization, function, and stability? Read on to find out more about the use of lipidated “fatty” amino acids!

Cys(Aapam): an Alloc protected Phacm linker as removable side chain modification for the incorporation of e.g. solubilizing tags facilitating the preparation of hydrophobic peptides and proteins.

Interested in structure activity studies on your Arginine containing peptide or further optimization for improved receptor binding? Explore our guanidino Proline derivatives as rigid Arginine mimics.

Are you using the Fmoc-MeDbz-OH Dawson Linker in large scale on a regular basis? A robust and economic processallows us to promptly provide you with kg quantities at competitive prices and in high quality.

Herein we present substituted diazacyclononynes (DACNs) as versatile tools for metal-free strain-promoted Click Chemistry that are characterized by high reactivity and stability, both thermally and chemically.

Herein, we present aminooxy-amino acids reported for peptide synthesis via oxime ligation, cyclization via oxime formation, derivatization e.g. by glycosylation, or chelation. Read on to find out more.

Herein we present two arginine derivatives, in which the native guanidino group is replaced by an isosteric amino-functionalized carbamoylated guanidino group that can serve as an attachment point for further derivatization.

The sterical interference of three closely positioned methyl groups favors amide cleavage and payload release upon lactonization. This cascade can be induced by various triggers. Read on to find out more.

The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.

Interested in the formation of peptide thioesters for Native Chemical Ligation? Read on to find out more about the use of Dawson Linker derivatives as thioester surrogates compatible with Fmoc SPPS.

Enzymatically-activatable probes based on 7-amino-4-methylcoumarin (AMC) represent versatile tools for the detection and localization of proteolytic enzyme activities. Read on to find out more.

Methionine is particularly prone to oxidation by atmospheric oxygen in vitro but also by reactive oxygen species in vivo, resulting in the corresponding sulfoxide and sulfone. Read on to find out more.

One approach for the design of bioactive peptides with improved pharmacological properties is the derivatization of amino acid building blocks with fluorine. Find out more about the advantages of fluorinated peptides.

Mpro is a key enzyme of coronaviruses (coronaviridae) and thus an attractive drug target. Iris Biotech offers fluorescent substrates, which can be used to perform various types of screenings and to identify potential inhibitors of COVID-19.

Interested in histidine derivatives? Iris Biotech provides a selection of deamino- and decarboxy-products. Find out more about benefits and potential applications of our new building blocks.

Fighting COVID-19 by modifying essential viral proteins via glycation through methylglyoxal – a reactive carbonyl compound known from the Maillard reaction. Read on to find out more!

Iris Biotech offers various linked kinase inhibitors including analogues of Gefitinib, Imatinib, Sunitinib, Staurosporine and many more, which can easily be conjugated to other biomolecules, if desired. Have a look and read more.

Iris Biotech presents (functionalized) fullerenes of different core size (C60 vs. C70) as versatile tools for multiple functionalization. Read more about their unique properties and fields of applications.

Iris Biotech presents the next-generation of hydrolysis-stable phosphono-analogs of pSer, pThr and pTyr. Fluorination renders the phosphonic acid more acidic and thus an even better mimic of the parent phosphoamino acid.

Isopropyl-β-D-thiogalactopyranoside (IPTG) is one of the most commonly utilized reagents in molecular biology.

Find out more about those building blocks with side chains able to coordinate metal ions, and why peptide-based HDACis are intriguing synthetic targets.

Learn, how His-Tag can be used for specific linker attachment. Another example in our LINKEROLOGY series of sophisticated linker technologies.

Amongst various somatostatin analogues, the pentacyclic heptapeptide TT-232 bears unique properties. Iris Biotech offers TT-232 as triacetate and trifluoroacetate salt, respectively, as well as conjugated to either biotin or the fluorophore indocyanine green.

Find out which Maillard Reaction Products from Iris Biotech were used in the development of a state-of-the-art analytical method for 15 different AGEs.

Placing Dde as one terminal group of a linker and a functional group prone for conjugation as the other or using Dde as the central connective portion of a linker, allows for the creation of new bifunctional linkers.

The ever-growing sophistication and variation in linker design have given rise to a new and distinct field of knowledge in synthetic chemistry termed Linkerology. Discover our expertise and panoply of new cutting-edge tailor-made linker constructs for the latest state-of-the-art bioconjugations.

Alkyne amino acids allow for Click conjugations and other types of chemistry. Read more about alkyne-functionalized amino acids and our related products.

DTT is a powerful yet mild reducing agent. Based on your demand we can offer different quality grades to suit your needs.

Sidechain-derivatized amino acids have shown great potential in enhancing select properties of peptide lead compounds. Find the most recent additions to our portfolio of amino acids bearing additional aryl and alkyl groups in their side chains.

The tremendous success of Liraglutide and Semaglutide has moved amino acids modified with lipids into the focus of many research endeavors. Delve into the treasure trove of our lipidated amino acids!

23 - 24 March 2020

Betulin and its derivatives are pentacyclic triterpenoids of the lupane-type. They are natural products that occur as secondary metabolites in over 200 different plants. Betulinic acid (BA) is a derivative of betulin that is oxidized at C-28.

27 - 29 January 2020

19 - 23 January 2020

Biotinylation of proteins and their purification via Streptavidin beads is a widely applied method.

Proximity labeling of proteins with biotin-phenol (biotin-tyramide) and an engineered peroxidase enzyme (e.g. APEX = Engineered Ascorbate Peroxidase) is a pivotal tool for molecular biology.

21 - 22 October 2019

Two selected publications were summarized in this article in order to highlight the impressive utility of amino acids incorporating the diazirine photophore.

8 - 13 September 2019

5 - 7 September 2019

3 - 5 July 2019

12 - 16 May 2019

24 - 25 April 2019

Protease inhibitors are molecules that inhibit protease function by binding either reversibly or irreversibly to the enzyme.

Methods for proteomic mapping of cellular organelles or subdomains that avoid the necessity of cell lysis and purification by targeting specific subcellular regions have several advantages.

28 February - 1st March 2019

o -Nitroveratryloxycarbonyl (Nvoc) is a photocleavable side chain protecting group for lysine that can be removed by irradiation with UV light (350 nm).

Succinylation of proteins on the epsilon-amino group of lysine residues is a posttranslational modification that is still poorly understood.

8 – 10 November 2018

10-13 September 2018

August 26-31, 2018

The 2D monolayer cell culture model is widely applied for drug screening. However, this approach is frequently not able to adequately mimic the in vivo response.

5 June 2018 Hotel Crowne Plaza Maastricht, The Netherlands

Phosphorylation of serine, threonine and tyrosine is counted among the most important posttranslational modifications that occur in organisms.

Iris Biotech introduces a comprehensive set of photo-crosslinking amino acids bearing the diazirine moiety.

The use of bioactive peptides has increased over the recent years as they attracted attention for their use as therapeutic agents.

16-17 April 2018

Polyarginines are well known for their ability to enhance cell penetration.

This alkyne-functionalized cysteine building block can be incorporated into peptides via the Fmoc strategy.

One role of proline in proteins is that a β-turn of a peptide chain is being induced at its position. Two major conformations, cis or trans, of the corresponding amid bond will induce that the protein folds in a specific way.

The Fmoc group is the most frequently used protecting group in peptide chemistry. The most common deprotection conditions involve a solution of 20% piperidine in DMF.

10 - 11 August 2017

This meeting intends to cover the various aspects of peptide-, protein chemistry as well as drug discovery and development, pharmacology, and structure-activity relationships. The meeting will take place on 08th June 2017 in Auditorium TU/e, Eindhoven, The Netherlands

24 - 25/04/2017

26 - 30/03/2017

Mercapto-PEG-Acids are highly hydrophilic, non-antigenic, non-immunogenic and non-toxic.

Azido and alkyne functions can cyclise by an intramolecular CuI or Cu0 catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC). This so-called Click Reaction, developed by K. Barry Sharpless and Morton Meldal, has meanwhile grown to a widely used type of reaction orthogonal to many other types of reactions in different kinds of applications.

a) Catalyst-free Click Reaction Cycloaddition reactions such as the [3+2] azide-alkyne and the [4+2] Diels-Alder reaction, are becoming common conjugation techniques. Applications range from imaging, drug design and development of sensors, thereby spanning the fields of chemical biology, material science, surface and polymer chemistry as well as many other fields. Introduced in 2002, the copper-catalyzed variant of the azide-alkyne cycloaddition (CuAAC) reaction has found broad applicability in t...

Mutant or modified aminoacyl tRNA synthetases (aaRS) have been used to charge non-natural amino acids to the corresponding tRNA, which incorporates them into polypeptides or proteins during recombinant synthesis.

Protein and lipid glycosilation is a life-governing and omnipresent process. Glycoconjugates display a multitude of biological effects from protein folding and stabilization, energy storage, cell surface interaction through molecular recognition motifs for cell-cell communication, and structural support and protection.

Trypsin (EC 3.4.21.4), an endopeptidase and natural protease found in the digestive system, cleaves peptide chains and proteins predominantly at the carboxyl side of the amino acids Lys and Arg (except when followed by Pro).

Polyamines such as ethylene diamine and its higher homologues are important feedstocks for the chemical industry. Compounds like putrescine, spermidine, and spermine play important roles in both eukaryotic and prokaryotic cells and show many other different biological functions.

Proteins contained in meat and other comestible goods are usually rich in the amino acids arginine and lysine. The side chain func- tional groups of Arg and Lys react with reducing carbohydrates such as glucose or lactose to form Amadori reaction products.

The polymers in this context are a polymeric linear structures with n repeating units of monomers. Depending whether the polymer is consisting of one single molecular weight (only one n existing) or of a range of compounds with an average mass and a distribution of n around a mean value, polymers are referred to as “monodisperse” or “polydisperse”.

Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have already been used as building blocks in polymer drug conjugates and polymeric micelles.

Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.

PEGs show a spectrum of unique physical and chemical properties, which have been described in literature extensively by the pioneers in PEGylation: Harris, Veronese and recently by Hermanson. Here are summarized the most common known properties.

Nanotechnology and nanobiotechnology using gold or silver particles, quantum dots or even magnetic particles are broadly diverse, rapidly expanding areas of study in medical diagnostics and therapeutics, sensoric and chemistry.

The Biopharmaceuticals market, estimated at US$ 200 billion globally in 2013 by reportbuyer.com (Biopharmaceuticals - A Global Market Overview, 2013, London), is further projected to reach US$ 500 billion by 2020, growing at 13.5 % CAGR between 2010 and 2020.

Small drug molecules and also large biomolecules like proteins or antibodies suffer rapid clearance from human body.

Abstract: A symposium report. Protected peptides were synthesized using 9-fluorenylmethoxycarbonyl (Fmoc) amino acids and the acid labile 2-chlorotrityl and the multidetachable 2-chlorotrityl-Rink-linker resins.

We now offer a series of Lysine dendrons for chemoselective functionalization of molecules containing carbonyl groups. These multivalent molecules carry diverse types of moieties, such as amine- or hydroxyl-groups, DOTA chelators or triphenylphosphonium (TPP) cations.

23-24 February 2017

This innovative auxiliary facilitates Native Chemical Ligation at the position of a Glycine residue in a peptide sequence. The auxiliary can be further functionalized, e.g. by PEGylation. Following NCL, the auxiliary is removed by irradiation with UV light.

September 4th - 9th, 2016 University Campus Augustusplatz Leipzig Germany

Omniligase-1 enables efficient and racemization-free ligation of two side-chain unprotected peptide fragments at many different positions. Test this innovative enzyme developed by EnzyPep B.V. using the complementary model peptides included in our kit!

June 3rd, 2016 Lelystad, The Netherlands Agora Congress Center This meeting intends to cover the various aspects of peptide-, protein chemistry as well as drug discovery and development, pharmacology, and structure-activity relationships. It will also be a great opportunity for PhD students and young scientists to learn about the many aspects of peptide research, and to discuss about peptide chemistry and biology with experienced researchers. Read more online

May 26th-27th, 2016 Lille, France The third Chemical Ligation Meeting is a one-day international meeting focused on ligation chemistry broadly defined. The meeting will cover a large range of topics from synthetic methodology applied to peptides, proteins, polysaccharides or nucleic acids to applications in medicine and materials.  Read more online

Chlorotoxin is a chloride channel blocker which has been found in the venom of the Egyptian scorpionLeiurus quinquestriatus.

The reaction between a tetrazine (Tz) and a trans -cyclooctene (TCO) is the innovative third generation Click reaction that proceeds without the use of copper or other catalyst. It is rapid, fully bioorthogonal and excels at very low concentrations.

Asymmetric Rhodamine 110 protease substrates are used for the determination of protease kinetics. The asymmetric structure of these dyes greatly simplifies the determination of enzyme kinetics, while the properties of Rhodamine 110 facilitate an uncomplicated readout.

Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.

Maillard Reaction Products (MRPs) result from the reaction of Arg and Lys side chains with reducing carbohydrates. MRPs are valuable markers for food quality and are used in many different branches of industry such as food, pharma, cosmetics and biochemistry.

2-Furyl-alanine can be incorporated into peptides via SPPS or by using enzymatic approaches. UV-irradiation in the presence of oxygen and a photosensitizer converts furyl-alanine to an intermediate that selectively reacts with certain nucleophiles. This property can be employed for site-specific labeling of peptides and proteins.

Our new Biotin-SS-Tyramide linker is a valuable tool for peroxidase-promoted targeted protein biotinylation. By using peroxidase-tagged antibodies, proteins and protein clusters can be selectively biotinylated, and then isolated using streptavidin. The biotin tag can be subsequently removed using reducing agents (e.g. glutathione).

5-oxa-Derivatives of Orn and Arg, respectively, these rare amino acids are produced by legumes as protection against herbivores. For your convenience, we offer building blocks of both amino acids compatible with standard Fmoc/ t Bu SPPS chemistry

l -Ornithine derivative containing peptides play important roles in SAR studies, enzyme inhibition and cancer research. We now offer a variety of N δ -substituted ornithines containing heterocyclic, aromatic and aliphatic groups, as well as N- substituted C3- and C4-analogs of ornithine.

Bulky glycine analogs are interesting molecules for creating peptide derivatives with certain biological activities, e.g. with antiviral properties. Furthermore, they are useful compounds for protein structure evaluation.

October 22 to 25, 2015 Ramada Couran Cove Island Resort, South Stradbroke Island, Queensland, Australia http://solidphase.org The symposium provides a superb opportunity for all practitioners of solid phase peptide synthesis together with those who use synthetic peptides for a myriad of applications to congregate at the beautiful Couran Cove Resort, South Stradbroke Island, a short ferry ride from the famed Gold Coast of Queensland .

October 25 to 30, 2015 Peppers Salt & Spa, Kingscliff, NSW, Australia http://www.ozpeptide.org/australian-peptide-conference-2015/australian-peptide-conference-2015/ In the 11th Australian Peptide Conference with typically some 200+ delegates the theme 'Peptide Discovery and Development' will address cutting edge areas of peptide and small protein research including: new bioactive peptides, advances in peptide and protein synthesis, target receptors and GPCRs, structure-based drug design, transc...

Oligo-glycines are either flexible linkers or form well defined rigid substructures. We offer a variety of oligo-glycines as building blocks which can easily be introduced into any molecule.

Surprising behavior of NXO-peptides. It is a significant property of peptides that oxalo-retro azapeptides have the same donor and acceptor distances and properties for hydrogen bridge formation as a tripeptide fragment and therefore induce beta-sheet formation at this position.

May 17th - 22nd, 2015 Village Vacances of Portbail Portbail, Normandie, France The attractive program of the 19ème Congrès du GFPP will cover all aspects of contemporary peptide and protein sciences in both basic and applied domains. The conference program will include a general-public lecture, 13 cutting-edge plenary lectures, 28 selected oral communications, and several dozen posters and partner exhibition stands.

June 10th - 12th, 2015 Reitoria of Universidade Nova de Lisboa Campus de Campolide, Lisboa, Portugal The 6th European Conference on Chemistry for Life Sciences (6th ECCLS) will be held in Lisbon, Portugal, in June 10-12, 2015. Lisbon meeting will be sixth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009), Budapest (2011) and Barcelona (2013) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge between chemi...

A set of new statin analogues, so called Super-Threonines, is available consisting of Fmoc protected L-enantiomers with all possible 4 stereoisomers of chiral centers in the side chain. They appear in nature as bridge building element in cyclodepsipeptides, like pipecolidepsin A, a compound which shows relevant cytotoxic activity in three human tumor cell lines (lung, colon, breast) and has unique structural features.

May 27th, 2015 Radboud University Nijmegen, The Netherlands The annual Dutch Peptide Symposium provides a unique opportunity for academic and industrial researchers working in the fields of peptide-, protein-, and amino acid chemistry to meet and exchange ideas, insights, and expertise. The 2015 edition of the Dutch Peptide Symposium will be held in Nijmegen on May 27.

June 9th - 12th, 2015 Palais Universitaire Strasbourg, France The use of biophysical techniques in drug discovery is rapidly increasing, and many pharmaceutical companies have set up in-house biophysical platforms to speed up the target-to-candidate process and improve the quality of small-molecule therapeutics through a better understanding of their interactions with their targets. The 2nd NovAliX Conference Biophysics in Drug Discovery 2015 intends to further develop the synergy between bi...

March 18th-21st, 2015 Technische Universität Darmstadt Darmstadt, Germany The 12th German Peptide Symposium 2015 will take place at the Technische Universität Darmstadt, Department of Chemistry, in Darmstadt, March 18 - 21, 2015. The meeting covers all fields of peptide science  ranging from peptide and protein synthesis, peptide structure to the application of peptides and peptidomimetics in medicine and material sciences.

February 19th-20th, 2015 Deutsche Akademie der Naturforscher Leopoldina Halle/Saale, Germany The "Halle Conference on Recombinant Proteins" provides an unique platform for the exchange of latest scientific and technological findings, know-how and expertise between scientists from academia and industry. Presenters from Pharma industry, Biotech industry and Academia talk about latest developments of protein-based therapeutics covering new formats, modifications, manufacturing, formulation and an...

February 10th, 2015 DECHEMA-Haus Frankfurt/Main, Germany   The one-day symposium, organised by the DECHEMA working group on novel bio-production systems, will focus on recent advancements in the production and the application of these artificial proteins.

Cleavable dipeptide linkers like Val-Ala and Val-Cit rely on processes inside the cell to liberate the payload, as they undergo rapid hydrolysis in the presence of lysosomal extracts or purified human cathepsin B.

1,4-substituted 1,2,3-triazole are isosteric to peptide bonds and result in peptide mimetics which even retain activity e.g. in case of certain tyrosinease inhibitors. We offer custom synthesis of Alkyne Amino Acid Analogues as building blocks for triazol formation via Click conjugation. Side chains can represent all natural amino acids or unusual residues. In combination with our alpha-azido acids we can offer the whole range of building blocks to design Click-peptide bond analogues for every proteinoge...

The presence of catalytic copper, limits the in vivo application of the Click this reaction for several reasons. We offer custom synthesis of Strained Cyclooctynes and Substituted 1,2,4,5- Tetrazines as building blocks for fast Click reactions in the absence of any catalyst.

GABA is a neurotransmitter in the central nervous system of mammals and its deficiency is associated with severe neurological disorders. Statine, a GABA analogue, occurs in several peptide APIs. Derivatives of gamma-amino acid analogues are of continued vital interest for a variety of applications in medicinal chemistry. We have a tool box available to offer a broad range of substituted gamma-amino acids and statines on custom synthesis basis.

Used for Efficient and Economic Bulk Synthesis of Peptide APIs: A new technology is available with a set of new preloaded resins, which enable the synthesis of peptide amides WITHOUT ANY LINKER. Amino acid amides, which bear a functional side chain, are immobilized on acid sensitive resins. This makes process development, small scale synthesis, bulk production and in-process control very easy. Find more technical details in our application for demonstration purposes with BIVALIRUDIN.

In modern biotechnology there are numerous applications for the luminogenic luciferase assay. We supply luciferin from mg scale for research applications like monitoring of gene expression or tumor growth up to kg quantities for hygiene surveillance in food industry

July 2nd - 4th, 2014 Rouen’s Law Faculty Rouen, Normandy, France The “Golden Jubilee” of the “Rencontres Internationales de Chimie Thérapeutique” (RICT) will focus on “Interfacing Chemical Biology and Drug Discovery” . Chemical Biology can be defined as the use of chemical tools to unravel biological processes. The chemical approach to Biology may not only contribute a quantitative framework for the description (and prediction!) of complex biological ev...

May 19th - 21th, 2014 Centro de Investigación Príncipe Felipe Valencia, Spain Unlike other Drug Delivery Symposia that have a broader remit, this unique conference series was specifically established to provide a forum for interdisciplinary exchange of state-of-the-art techniques and advances in knowledge relating to the design, clinical development and commercialisation of Polymer Therapeutics. The key topics discussed during the 10th International Symposium on Polymer Therapeutics are...

May 13th, 2014 Universiteit Utrecht Netherlands The annual Dutch Peptide Symposium provides a unique opportunity for academic and industrial researchers working in the fields of peptide-, protein-, and amino acid chemistry to meet and exchange ideas, insights, and expertise. The 2014 edition of the Dutch Peptide Symposium will be held in Utrecht on May 13.

Tyramine compounds are converted to highly reactive radicals by horseradish peroxidase in presence of H2O2 which preferentially react with surface exposed tyrosines. Biotin Tyramide and Biotin-PEG-Tyramide therefore are ideal reagents used for tyrosine-/protein-biotinylation.

March 27th - 29th, 2014 Mosbach/Baden Germany The spring meetings of the German Society for Biochemistry and Molecular Biology (GBM) are held annually in the picturesque town of Mosbach to promote the exchange of scientific ideas and education of young scientists. The scientific theme of the 65th meeting is “Molecular quality control of proteins in health and disease”.

Bis Thiol & Amine reactive PEGylated Cross-Linker which has been used for enhanced receptor binding, for the design of long-acting conjugates for type 2 diabetes therapeutics and in reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators.

Phthalimidooxy PEG-based cross linkers form stable oximes with aldehydes, also latent ones as present in carbohydrates. Their reactivity is sufficiently mild for a broad used in creating conjugates with sensitive biologics.

Superior Performance at a Sensational Price! Available as –COOH, -NHS, -Maleimide, -Alkyne, -Azide Half the price of other well-known dyes like Alexa- & Cy-Dyes. Available also in large quantities. Broadly applied in cell imaging, FRET, fluorescence quenching.

Compounds like putrescine, spermidine, and spermine play important roles in a many biological functions. Many of them are excellent targets for oncology studies and other fields of medicinal chemistry. Find in our new brochure Diamines & Polyamines our possibilities for custom synthesis and a set over 100 available derivatives.

DTNB, frequently called Ellman’s Reagent, used as reagent for determination of free sulfhydryl groups.

Resin especially designed for the synthesis of long and difficult peptide sequences!

March 18th-21st, 2013 TU Munich Munich, Germany The meeting will cover many fields of peptide science including peptides/peptidomimetics in medicine, peptide and protein synthesis, peptide structure and folding, peptide interactions, and peptide misfolding and self-assembly.

June 10th-12th, 2013 Auditorio AXA Barcelona, Spain Barcelona meeting will be fifth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009) and Budapest (2011) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge from chemistry to biology. 

Any amino acid can be functionalized on the N-terminus with oxalic acid and on the C-terminus with hydrazine, in order to form a so-called NXO building block. Through this double modification N and C terminus will be inverted, which provides interesting structural options for peptidomimetics.

Aryl azides are well-known precursors of nitrenes and have been introduced by Fleet  et al . as versatile photoaffinity labeling agents to probe biological receptors.

Long-chain acylcarnitines are well-known intermediates in mitochondrial fatty acid oxidation

A prominent luciferase group was first discovered in Coelenterata and the corresponding light emitting molecule was therefore named coelenterazine.

The overall goal of our research is to capitalize on peptides of natural origin and their biological activity and chemistry.

September 2nd - 7th, 2012 Athens, Greece Megaron Conference Centre   With more than 550 submitted abstracts and more than 500 already registered participants coming from more than 40 different countries, the 32nd European Peptide Symposium assures an exciting scientific program.

June 07th-10th, 2012 Naples, Italy The Workshop, designed to provide updated information and to critically discuss current trends on synthetic and conformational aspects of bioactive peptides, will deal in the 13th edition with the general topic: “Conformation and Activity in Peptides: Relationships and Interactions” .

Our portfolio currently contains over 5500 products. Many of them – in particular standard consumables for peptide synthesis – are being produced in bulk quantities.  Therefore we can keep our prices also for lab quantities at very competitive level. In case of need for bulk quantities please inquire: - All 20 Proteinogenic  Fmoc-protected Amino Acids  are available in 100+ kg Lots;

GFPP – 2011 Groupe francais des peptides et des protéines 30 Jan – 4 Feb, 2011, Aussois, France ( www.gfpp.free.fr/17_conferenciers )

H-L-Aha-OH*HCl H-L-Dab(N3)-OH 4-Azido-L-homoalanine (S)-2-Amino-4-azidobutanoic acid hydrochloride Formula:                    C 4 H 8 N 4 O 2 *HCl Molecular Weight:     144,13*35,45 g/mole CAS:  942518-29-8 CODE:  HAA5730 1g:       EUR    200,-    US$    300,-  5g:   ...

Cleland's reagent, also known as dithiothreitol or DTT is a water soluble protective reagent for sulfhydryl groups. It reduces disulfide linkages to free sulfhydryl groups in proteins and enzymes. It is a component of buffers used in protocols for the isolation and purification of proteins. DTT (racemic), Cleland's Reagent

Dendrimers offer a new possibility to derivatize small molecules, surfaces or biopharmaceuticals with a monodisperse macromolecule and alter in this way properties like solubility and hydrophilicity. Immunogenicity and pharmacokinetics of pharmaceuticals will be improved. The synthetic approach for designing these dendrons of different generations is based on 2,2-bis(hydroxymethyl) propionic acid, which is a non-toxic and biocompatible building block. The size can be designed from 250 g/mole for 1st gene...

Abstract: In 2006 the market of modern biopharmaceuticals has reached a volume of over 3 billion in USA and over billion world wide (IMS Health, Inc.).

Abstract: N alpha-9-Fluorenylmethoxycarbonyl-N epsilon-4=methyltrityl-lysine, [Fmoc-Lys(Mtt)-OH], was prepared in two steps from lysine, in 42% overall yield.