Search results for: 'pyrrolidine'

PotM: Aminoprolines - Controlling the Folding

You are looking for a building block suitable to control the folding characteristics of your peptide or want to add a pH-sensitive conformational switch? Discover aminoprolines and their properties!
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PotM: Methanoprolines and Dimethylprolines - Constraining the Conformation of Peptides

Interested in structure-activity studies of your Proline-containing peptide drug? Find out more about the use of Methanoprolines and Dimethylprolines as conformational amide locks.
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Proline Scaffold

One role of proline in proteins is that a β-turn of a peptide chain is being induced at its position. Two major conformations, cis or trans, of the corresponding amid bond will induce that the protein folds in a specific way.
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Prolines with Hydrophobic Substituents

Prolines are key elements positioned at the edge of β-turns in peptides. With modified prolines these positions can be used for either covalent amide or disulfide bonds – as we have demonstrated in many examples – or for filling hydrophobic pockets, whenever the pyrrolidine ring is substituted with groups like Methyl or Phenyl.
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