Search results for: 'tis'

Game Changer for Protein Modification: Discover oxidation-induced furan crosslinking and 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones ( 5HP2O s) as stable alternative to maleimides.

HMPO (5-(hydroxymethyl)pyrogallol orthoester), a plasma-stable, pH-sensitive, 1,6-self-immolative crosslinker derived from the natural product gallic acid. Discover its properties!

Tetrahydropyranyl (THP) is an excellent protective group for hydroxy and thiol moieties but rarely used in solid-phase peptide synthesis (SPPS). Discover its advantages, e.g., over O/S t Bu and Trt.

To address both chemical and IP considerations in self-immolating linker applications , we propose shifting from the commonly used Val-Cit-PAB linker to the less explored Gly-Gly-Phe-Gly-formyl motif.

What’s new? Don’t miss innovative building blocks and latest technologies – have a look at our new products flyer and discover our portfolio additions from January to June 2024!

Wondering about the difference between Boc and Fmoc chemistry in solid phase peptide synthesis? Don't worry: in this short overview we will guide you through the basics of both strategies.

Proposing norbornenes – strained, bicyclic alkenes for fast, copper-free, biocompatible click-conjugation with tetrazines. Read on for more details on applications and available products!

Discover photocages – photosensitive protecting groups that are removed by irradiation with light of a defined wavelength, thus restoring the original, “active” state.

Engineer shape-shifting peptides , controllable by a laser as magic wand! In this newsletter, we’ll explore the possibilities of photo switchable building blocks based on azobenzene.

You missed our workshop featuring Dr. Fabio de Moliner & Prof. Dr. Marc Vendrell? Watch the Recording! Any further questions? Please get in contact via info@iris-biotech.de.

Boron is not boring at all! Today, we'll delve deeper into the exciting world of boronate-containing amino acid building blocks and unlock the potential of the next generation of peptides. Read on!

You are looking for a building block suitable to control the folding characteristics of your peptide or want to add a pH-sensitive conformational switch? Discover aminoprolines and their properties!

Curious about the highlights of our 2023 portfolio additions? Discover innovative building blocks and latest technologies! Read on to check out the summary or get in contact if you need more details!

You missed our workshop featuring Dr. Quibria Guthrie (CEM Corporation)? Any further questions? Please get in contact via info@iris-biotech.de.

Discover possibilities to fight chronic pain diseases by employing linker technologies. Check out the options for multiple drug conjugation in combination with different release mechanisms.

One molecule, two identities: PNAs are composed of nucleobases arranged on a peptidic backbone. Discover our PNA building blocks as ready-to-use bases suitable for SPPS.

You missed our workshop featuring Dr. Stefan Kubick (B4Pharmatech, Berlin)? Any further questions? Please get in contact via info@iris-biotech.de  

The potential of natural products of daily life , such as 6-shogaol from ginger ( Zingiber officinale) , can flourish if the active ingredient is conjugated to an appropriate carrier via Linkerology®. 

Discover the cyanobenzothiazole (CBT) click reaction , a not (yet) so well-known biocompatible and bio-orthogonal mechanism faster than the famous azide-alkyne cycloaddition (CuAAC).

Building blocks with a strained triple bond do not require copper catalysis when used in click chemistry. Discover CliCr®: improved solubility in aqueous conditions and high reactivity! Click here!

Maleimides provide versatile options for connecting payloads to proteins and other biomolecules. Discover how our bifunctional thiol reactive crosslinkers can support your project. Read on!

Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!

The HaloTag®, SNAP-Tag® and CLIP-Tag TM represent versatile tools for the specific, covalent attachment of in principle any molecule of choice to a protein of interest. Discover our substrates!

(Bi)functional dioxoborolane and disulfide-based self-immolative linkers – mode of action and application examples for the detection of H 2 O 2 , for prodrug design, and reversible peptide cyclization.

Linkers serve as versatile tools, e.g. during SPPS or for the sophisticated (self-immolative) conjugation of a potent small molecule to a carrier. Check out our selection of over 100 readily available linkers.

You want to get an overview about the various resins available at Iris Biotech as well as their specifications, differences, and applications? Read on for further information and details.

We are highly excited to see the research that our products are used for. Send your peer-reviewed scientific publication to publication@iris-biotech.de for citation – we will reward you.

Herein, we present 2-Iminobiotin, a cyclic guanidino analogue of biotin with pH-dependent affinity for avidin, and compare it to biotin and desthiobiotin. Click here for more detailed information.

The para -azido benzyloxycarbonyl protected lysine building block Fmoc-L-Lys(4-N3-Z)-OH (FAA8830) is useful for a wide range of applications. Read on to find out more!

June 16 th - 18 th 2022

Dyes and fluorescent labels are an invaluable tool for diagnostics, medical and biochemical research. Iris Biotech offers labels with excitation ranges from UV to near-IR and various functional groups.

Iris Biotech is your trusted partner in the world of peptides and all related disciplines. Your project requires a compound not listed in our portfolio? Get in contact and inquire for a custom synthesis!

Discover our selection of disulfide-based self-immolative linkers allowing to influence linker stability, fine-tune the self-immolative cleavage rate and thus impact the speed of the payload release.

You missed our workshop featuring Dr. Nadja Berger and Dr. Manoj Kumar Muthyala (R&D Scientists; Belyntic GmbH)? Any further questions? Please get in contact via info@iris-biotech.de.

Discover our selection of propargyl-substituted amino acids and find the best position for subsequent Click chemistry within your peptide/protein. Just click here for further information on our products.

Herein we present a series of alpha,alpha-cycle-disubstituted amino acid derivatives used in peptide design for their structure promoting effects as well as conformational rigidity.

Discover the versatile applications of hydrazone resins e.g. for the preparation of peptide hydrazides, or the generation of peptide thio esters. Read on to find out more and see our available products.

The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.

The sterical interference of three closely positioned methyl groups favors amide cleavage and payload release upon lactonization. This cascade can be induced by various triggers. Read on to find out more.

The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.

One approach for the design of bioactive peptides with improved pharmacological properties is the derivatization of amino acid building blocks with fluorine. Find out more about the advantages of fluorinated peptides.

Nitrodibenzofuran (NDBF) is a photocleavable side chain protecting group that can be removed by photolysis upon irradiation with UV-light or – especially for in vivo applications – by two-photon excitation using near infrared light.

Iris Biotech presents (functionalized) fullerenes of different core size (C60 vs. C70) as versatile tools for multiple functionalization. Read more about their unique properties and fields of applications.

Find out more about those building blocks with side chains able to coordinate metal ions, and why peptide-based HDACis are intriguing synthetic targets.

We, Iris Biotech GmbH, are pleased that Dr. Thomas Bruckdorfer completes the BIOPARK8-Brain-Network in Regensburg and will enrich it with our experience.

Amongst various somatostatin analogues, the pentacyclic heptapeptide TT-232 bears unique properties. Iris Biotech offers TT-232 as triacetate and trifluoroacetate salt, respectively, as well as conjugated to either biotin or the fluorophore indocyanine green.

The ever-growing sophistication and variation in linker design have given rise to a new and distinct field of knowledge in synthetic chemistry termed Linkerology. Discover our expertise and panoply of new cutting-edge tailor-made linker constructs for the latest state-of-the-art bioconjugations.

Sidechain-derivatized amino acids have shown great potential in enhancing select properties of peptide lead compounds. Find the most recent additions to our portfolio of amino acids bearing additional aryl and alkyl groups in their side chains.

29 - 31 January 2020

19 - 23 January 2020

12 - 15 November 2019

17 - 20 June 2019

9 - 11 April 2019

Protease inhibitors are molecules that inhibit protease function by binding either reversibly or irreversibly to the enzyme.

3 - 7 December 2018

Succinylation of proteins on the epsilon-amino group of lysine residues is a posttranslational modification that is still poorly understood.

Indocyanine Green (ICG) dye, a material approved by the FDA for various applications, is a powerful tool for imaging in live cells and tissues .

The 2D monolayer cell culture model is widely applied for drug screening. However, this approach is frequently not able to adequately mimic the in vivo response.

June 7-9, 2018 Aula Magna Partenope, Centro Congressi “Federico II” Naples, Italy

5 June 2018 Hotel Crowne Plaza Maastricht, The Netherlands

May 7-10, 2018

February 28th – March 1st, 2018

Poly-(α-L-glutamic acid) is a synthetic polypeptide of L-Glu linked by the alpha-amino groups (α-PGA). These polyanionic and biodegradable polymers can be used for a variety of purposes.

Polylysines are polymers of the canonical amino acid Lysine, and are characterized by their high charge density caused by the presence of one free amino group per lysine monomer.

5 - 7 July 2017

25 - 28 June 2017

17 - 22 June 2017

This meeting intends to cover the various aspects of peptide-, protein chemistry as well as drug discovery and development, pharmacology, and structure-activity relationships. The meeting will take place on 08th June 2017 in Auditorium TU/e, Eindhoven, The Netherlands

Mercapto-PEG-Acids are highly hydrophilic, non-antigenic, non-immunogenic and non-toxic.

Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have already been used as building blocks in polymer drug conjugates and polymeric micelles.

Paolo Braiuca, Knapic Lorena, Valerio Ferrario, Cynthia Ebert, and Lucia Gardossi Adv. Synth. Catal. 2009; 351 : 1293–1302 https://doi.org/10.1002/adsc.200900009   Abstract: Computational techniques involving molecular modeling coupled with multivariate statistical analysis were used to evaluate and predict quantitatively the enantioselectivity of lipase B from Candida antarctica (CALB). In order to allow the mathematical and statistical processing of the experimental data largely ava...

Abstract: A symposium report. Protected peptides were synthesized using 9-fluorenylmethoxycarbonyl (Fmoc) amino acids and the acid labile 2-chlorotrityl and the multidetachable 2-chlorotrityl-Rink-linker resins.

Conjugates of PEG and folic acid or cholesterol, respectively, combine the positive properties of these molecules. Those conjugates are available with a wide variety of functional groups and different PEG chain lengths to suit your needs.

May 26-27,  2016 Hungarian Academy of Science Budapest, Hungary

June 3rd, 2016 Lelystad, The Netherlands Agora Congress Center This meeting intends to cover the various aspects of peptide-, protein chemistry as well as drug discovery and development, pharmacology, and structure-activity relationships. It will also be a great opportunity for PhD students and young scientists to learn about the many aspects of peptide research, and to discuss about peptide chemistry and biology with experienced researchers. Read more online

Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.

5-oxa-Derivatives of Orn and Arg, respectively, these rare amino acids are produced by legumes as protection against herbivores. For your convenience, we offer building blocks of both amino acids compatible with standard Fmoc/ t Bu SPPS chemistry

October 19 to 21, 2015 Sheraton San Diego Hotel & Marina, San Diego, CA, USA http://worldadc-usa.com More than 600 scientists from all over the world will gather for the leading conference in the field of Antibody Drug Conjugation . Learn how the industry’s best are innovating drug-linker chemistries to maximize efficacy and tolerability. Find new toxic molecules as potential payloads and see how Iris Biotech can support you with peptide and PEG based linker technologies.

A new hydrazone resin enables a convenient way to synthesize peptide hydrazides for Hydrazone Ligation Technique and Native Chemical Ligation (NCL).

July 1st - 3rd, 2015 Université d’Avignon et des Pays de Vaucluse Avignon, France RICT 2015 - the 51st edition of the International Conference on Medicinal Chemistry - is expected to gather 550-600 scientists from around the world, with a majority of scientists coming from Europe. The scientific programme, which will include over 25 plenary lectures by internationally well-known scientists, will focus on " Drug Discovery and Selection - Understanding Targets and Mechanisms ", coverin...

Alkylating the Nitrogen of an amide bond results in peptoid structures, leading to conformational restrains, like N-methylation and allows backbone derivatisation. Applications already have been published with Cilengitide, Piscidin 1, and MC4 receptor agonist.

June 10th - 12th, 2015 Reitoria of Universidade Nova de Lisboa Campus de Campolide, Lisboa, Portugal The 6th European Conference on Chemistry for Life Sciences (6th ECCLS) will be held in Lisbon, Portugal, in June 10-12, 2015. Lisbon meeting will be sixth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009), Budapest (2011) and Barcelona (2013) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge between chemi...

June 8th - 11th, 2015 University of Lorraine, Campus du Saulcy Metz, France The Bioheterocycles 2015 - XVI International Conference on Heterocycles in Bioorganic Chemistry is a continuation of the series started by Professor Henk van der Plas in 1980. Since that time the boundaries of bio-organic chemistry have been expanded significantly and we feel it is time to learn about the latest progress in the field. The objective is to facilitate fruitful interaction of young scientists with internat...

May 27th, 2015 Radboud University Nijmegen, The Netherlands The annual Dutch Peptide Symposium provides a unique opportunity for academic and industrial researchers working in the fields of peptide-, protein-, and amino acid chemistry to meet and exchange ideas, insights, and expertise. The 2015 edition of the Dutch Peptide Symposium will be held in Nijmegen on May 27.

February 19th-20th, 2015 Deutsche Akademie der Naturforscher Leopoldina Halle/Saale, Germany The "Halle Conference on Recombinant Proteins" provides an unique platform for the exchange of latest scientific and technological findings, know-how and expertise between scientists from academia and industry. Presenters from Pharma industry, Biotech industry and Academia talk about latest developments of protein-based therapeutics covering new formats, modifications, manufacturing, formulation and an...

Aminoisobutyric acid (Aib) and its homologues are a strong helix promoters in peptide mimetics. Aib-containing model peptides are already used in cancer treatment, antimicrobial peptides and cell penetrating peptides (CPP). We offer Aib and its homologues positioning the dimethyl fragment either close to the N- or to the C-terminus.

November 26th - 28th, 2014 Kobe International Conference Center Kobe, Japan The MCS2014 provides superb opportunities for participants to expand scientific knowledge and information on medicinal chemistry, and also to build collaboration and networking. The scientific program will include 10 special lectures by invited speakers and winners of the award of PSJ DMC and over 100 general presentations (short oral and poster presentations) on the basic and application research in medicinal chemistry. ...

August 31st - September 5th, 2014 National Palace of Culture Sofia, Bulgaria The 33 rd European Peptide Symposium will provide a great opportunity to exchange ideas and to create new collaborations between successful scientists working in the field of Chemistry, Biology and Pharmaceutical industry related to Peptide Science. The event will offer a varied scientific program, including young scientists’ mini symposium, poster sessions, industrial exhibitions and attractive social program.

July 2nd - 4th, 2014 Rouen’s Law Faculty Rouen, Normandy, France The “Golden Jubilee” of the “Rencontres Internationales de Chimie Thérapeutique” (RICT) will focus on “Interfacing Chemical Biology and Drug Discovery” . Chemical Biology can be defined as the use of chemical tools to unravel biological processes. The chemical approach to Biology may not only contribute a quantitative framework for the description (and prediction!) of complex biological ev...

June 23rd - 26th, 2014 San Diego Convention Center San Diego, CA The BIO International Convention is the largest global event for the biotechnology industry and attracts the biggest names in biotech, offers key networking and partnering opportunities, and provides insights and inspiration on the major trends affecting the industry.

May 13th, 2014 Universiteit Utrecht Netherlands The annual Dutch Peptide Symposium provides a unique opportunity for academic and industrial researchers working in the fields of peptide-, protein-, and amino acid chemistry to meet and exchange ideas, insights, and expertise. The 2014 edition of the Dutch Peptide Symposium will be held in Utrecht on May 13.

March 27th - 29th, 2014 Mosbach/Baden Germany The spring meetings of the German Society for Biochemistry and Molecular Biology (GBM) are held annually in the picturesque town of Mosbach to promote the exchange of scientific ideas and education of young scientists. The scientific theme of the 65th meeting is “Molecular quality control of proteins in health and disease”.

November 13th, 2013 Rudolf-Virchov-Zentrum Würzburg, Germany Iris Biotech GmbH nimmt am 6. Kooperationsforum Drug Developement - Targets-Design-Screening-  teil, wo über neuste Technologien und aktuelle Konzepte der Arzneimittelentwicklung zu informiert wird.

June 10th-12th, 2013 Auditorio AXA Barcelona, Spain Barcelona meeting will be fifth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009) and Budapest (2011) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge from chemistry to biology. 

June 22nd– 27th, 2013 Hilton Waikoloa Village Hawai‘i, USA The Symposium will follow its long standing tradition of featuring talks by leading scientists from the academic and industry communities sharing current and compelling peptide research.

July 3-5, 2013 Nice, France Meet us at the RICT Symposium ( 49th International Conference on Medicinal Chemistry ), Nice. Booth #14

Press release (german text,  pdf Download-Version ) IRIS Biotech bringt neue Innovationen auf den Markt Das in Marktredwitz in Oberfranken/Ostbayern beheimatete Unternehmen IRIS Biotech GmbH hat durch Intensivierung seiner Zusammenarbeit mit Forschungsinstitutionen den Zeitraum der Markteinführung neuer Produktgruppen drastisch verkürzt. Derzeit kooperiert das Unternehmen mit 35 ausgewählten Herstellern und Universitäten aus aller Welt...

Pressemitteilung ( pdf Download-Version ) IRIS Biotech bringt neue Innovationen auf den Markt Das in Marktredwitz in Oberfranken/Ostbayern beheimatete Unternehmen IRIS Biotech GmbH hat durch Intensivierung seiner Zusammenarbeit mit Forschungsinstitutionen den Zeitraum der Markteinführung neuer Produktgruppen drastisch verkürzt. Derzeit kooperiert das Unternehmen mit 35 ausgewählten Herstellern und Universitäten aus aller Welt...

July 04th-06th, 2012 Poitiers, France This major international symposium will gather more than 450 scientists from around the world at the Faculty of Medicine and Pharmacy in Poitiers. The scientific programme, which will include over 25 plenary lectures by internationally well-known scientists, focuses on "Interfacing Chemical Biology and Drug Discovery", covering the main stages of modern drug discovery.

May 23rd, 2012 Zentrum für Umwelt und Kultur, Benediktbeuern, Germany For details on the meeting please follow this link to the official website of Biopharmaceuticals Bayern

March, 29th - 31th, 2012 Mosbach, Germany Once again outstanding scientists will present their work focussed on Posttranslational Modifications at the Mosbacher Kolloquium. Under the headline "Post-translational modifications in signal integration and molecular Therapies" the Kollogium will be an interesting event.

February 12 th - 15 th , 2012 Dubai, UAE This unique international conference provides a platform for all pharmaceutical scientists, internists and primary care physicians to discuss and learn about all the important international breakthrough developments in drug discovery and on new therapeutics.