Search results for: 'tran'

Benefit of our latest Maillard Reaction Product additions! Use them as reference standard for quality control and food analysis or synthesize modified peptides for research studies.

We expanded our portfolio of Fmoc-protected homo amino acids . Benefit of their unique properties to modulate the stability, hydrophobicity, and biological performance of your peptide!

Discover MYTsA as coupling reagent for peptide synthesis in “traditional” C→N and vice versa in “natural” N→C direction. Avoid racemization and benefit of improved atom economy!

Tetrahydropyranyl (THP) is an excellent protective group for hydroxy and thiol moieties but rarely used in solid-phase peptide synthesis (SPPS). Discover its advantages, e.g., over O/S t Bu and Trt.

Where does life come from and how can we simulate early earth conditions leading to simple organic molecules such as nucleotides and amino acids, the building blocks of RNA and peptides?

Green – Yellow – Red – Grey. To increase transparency in terms of expected shipping times, we have introduced a color code in our webshop indicating product and packing unit availabilities.

Same but different! Expand your possibilities for peptide modification and fine-tuning by implementing N ω -carbamoylated arginine building blocks as bioisosteric arginine analogs.

Novel excipients can help you master the challenges associated with the production and formulation of protein- and RNA-based drugs due to their inherent fragility. Discover the SURPAX TM technology!

Use the possibilities of Linkerology® to boost the efficacy of your drug! We illustrate how the drug Gepirone (Exxua TM ), a medication to treat major depressive disorders, can be conjugated.

Clever Move - Add positive effects to your molecule by introducing the most electronegative element. Discover fluorinated building blocks as game changer for your lead development. 

Level up! Carboxymethyl-modified amino acid building blocks suitable for incorporation by solid-phase peptide synthesis. Learn more about available derivatives and their properties.

Discover photocages – photosensitive protecting groups that are removed by irradiation with light of a defined wavelength, thus restoring the original, “active” state.

Engineer shape-shifting peptides , controllable by a laser as magic wand! In this newsletter, we’ll explore the possibilities of photo switchable building blocks based on azobenzene.

You are looking for monodisperse Sarcosines ? You want to use Sarcosine for SPPS? You need to improve your drug's hydrophilicity and search for PEG alternatives? Read on!

You missed our workshop featuring Dr. Fabio de Moliner & Prof. Dr. Marc Vendrell? Watch the Recording! Any further questions? Please get in contact via info@iris-biotech.de.

Boron is not boring at all! Today, we'll delve deeper into the exciting world of boronate-containing amino acid building blocks and unlock the potential of the next generation of peptides. Read on!

The targeted delivery and traceless release of drugs is an important concept in pharmacology. Discover the possibilities of payload conjugation to carrier proteins shown for the example drug Elacestrant.

You are looking for a building block suitable to control the folding characteristics of your peptide or want to add a pH-sensitive conformational switch? Discover aminoprolines and their properties!

The tetrazole isostere of malonyllysine is thermally stable and does not suffer from decarboxylation. Discover our building blocks suitable for incorporation via solid-phase peptide synthesis.

Curious about the highlights of our 2023 portfolio additions? Discover innovative building blocks and latest technologies! Read on to check out the summary or get in contact if you need more details!

Discover possibilities to fight chronic pain diseases by employing linker technologies. Check out the options for multiple drug conjugation in combination with different release mechanisms.

Add glycans to your proteins with our ready-to-use Fmoc asparagine building blocks suitable for solid phase peptide synthesis and produce peptides with exactly defined glycosylation patterns!

The discovery of the Merrifield peptide synthesis paved the way for automated solid-phase peptide synthesis (SPPS) enabling fast and convenient simultaneous peptide synthesis.

One molecule, two identities: PNAs are composed of nucleobases arranged on a peptidic backbone. Discover our PNA building blocks as ready-to-use bases suitable for SPPS.

Ongoing research efforts lead to the discovery of innovative building blocks and new APIs. However, for industrial applications, upscaling is required. Herein, we share the process development for Fmoc-Cys(Msbh)-OH.

You missed our workshop featuring Dr. Stefan Kubick (B4Pharmatech, Berlin)? Any further questions? Please get in contact via info@iris-biotech.de  

Discover our new building block 4-(azido-propyl-tetrazine)phenylalanine (pTAF) and make use of the orthogonality of the 2 nd and 3 rd generation Click reaction to build multiconjugates via double-Click.

You want to attach your small molecule to a certain carrier? Let’s analyze the functional groups present and discuss Linkerology® possibilities for permanent or trigger-inducible, tracelessly-cleavable linkage.

Bioengineering in combination with Linkerology® . Check out the unique options for membrane proteins, recombinant immunotoxins (RITs) and novel antibody-drug conjugates.

Allotropes of carbon show distinct characteristics in structure and e.g. electric and biophysiological properties. Discover how these materials can be further exploited by linker attachment!

Discover the cyanobenzothiazole (CBT) click reaction , a not (yet) so well-known biocompatible and bio-orthogonal mechanism faster than the famous azide-alkyne cycloaddition (CuAAC).

Curious about our latest portfolio additions from January to June 2023? Discover our New Products Flyer and check out the summary of recent product highlights! Get in contact for more details!

Discover our diazirine-substituted building blocks suitable for the analysis of protein-protein and RNA-protein interactions via proximity labeling upon photoactivation. Read on for more information!

Plasma technology allows to equip inert polymers such as poly(ethylene) or polystyrene with functional groups like amine or carboxylate enabling further conjugations and applications. Read on!

You missed our workshop featuring Prof. Rob Liskamp (Cristal Therapeutics, University of Maastricht, University of Glasgow)? Any further questions? Please get in contact via info@iris-biotech.de.

Our building block Fmoc-L-Cys(Cam)-OH enables peptides resembling reduced and carbamido-methylated protein fragments by standard SPPS without error-prone modification reactions.

Plant-derived Cholesterol of high and consistent product quality in accordance with Pharmacopoeia requirements to replace established animal source material in LNP formulation. Read on!

Building blocks with a strained triple bond do not require copper catalysis when used in click chemistry. Discover CliCr®: improved solubility in aqueous conditions and high reactivity! Click here!

From evolution to solution - natural products are an infinite source of (bio)active compounds. In this series we present how natural products can be conjugated to empower their inherent potential.

Our monofunctionalized dextrans are enriching the toolbox of polymer therapeutics – Dextrans benefit of excellent solubility, biocompatibility, biodegradability, and non-immunogenicity.

Coupling Reagents are required for the formation of an amide or ester bond. As simple as those reactions seem to be, the choice of the appropriate reagent is crucial for optimizing purity and yield.

You missed our workshop featuring Prof. Christian F. W. Becker (University of Vienna)? Any further questions? Please get in contact via info@iris-biotech.de.

Herein, we present functionalized perfluorobiphenyl building blocks which can be used for site-selective π -clamp mediated cysteine conjugation. Read on for more details about this general method!

Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!

The HaloTag®, SNAP-Tag® and CLIP-Tag TM represent versatile tools for the specific, covalent attachment of in principle any molecule of choice to a protein of interest. Discover our substrates!

Herein, we present CliCr® as an innovative cyclic alkyne for metal-free strain-promoted click chemistry. Read our blog for detailed information about CliCr® reagents based on TMTHSI and check out available derivatives!

Curious about our latest portfolio additions from July to December 2022 and the 2022’s overall product and newsletter highlights? Click here to check out the summary or get in contact for more details!

We can’t get enough of new products and innovations! Read this blog to get detailed information on the cyanylating reagent NTCB as well as selenocysteine amino acids, both useful tools for peptide ligation.

See how our “mRNA grade” DTT and Spermidine can support also your nucleic acid production. Read on for more information.

The 2022 Chemistry Nobel prize is awarded to B. Sharpless, M. Meldal and C. Bertozzi for their work in the field of Click Chemistry. At Iris, we are providing clickable building blocks for nobel chemistry. Read on for more information!

From mg synthesis of a peptide up to bulk quantities often makes a huge difference in the route of production. Read on for more information about Iris Biotech’s process development services.

Herein, we present the Clean Peptide Technology using Smoc Amino Acids developed by Sulfotools in Germany. Replace organic solvents with water during peptide synthesis - Read on for more information!

You want to get an overview about the various resins available at Iris Biotech as well as their specifications, differences, and applications? Read on for further information and details.

Herein, we present 2-Iminobiotin, a cyclic guanidino analogue of biotin with pH-dependent affinity for avidin, and compare it to biotin and desthiobiotin. Click here for more detailed information.

The para -azido benzyloxycarbonyl protected lysine building block Fmoc-L-Lys(4-N3-Z)-OH (FAA8830) is useful for a wide range of applications. Read on to find out more!

Photoswitches grant the ability to modulate the function of a molecule by effecting a structural change upon irradiation with UV light. Find out about our photoswitchable building blocks and their properties.

Iris Biotech is your trusted partner in the world of peptides and all related disciplines. Your project requires a compound not listed in our portfolio? Get in contact and inquire for a custom synthesis!

Drug the undruggable – click here to get more information about the use of PROteolysis TArgeting Chimeras (PROTACs®) as a tool for targeted protein degradation and discover available building blocks.

We are providing variously functionalized, protected and unprotected fatty acid derivatives suitable for SPPS and further conjugation, e.g. via Click chemistry. Read on to discover our portfolio.

Oxidation is not only a known degradation pathway of proteins and peptides in vivo but is also a major side reaction for certain amino acids during peptide synthesis in vitro. Read on to discover our available building blocks.

Interested in polymers for the delivery of promising drug candidates, e.g. nucleic acids? Discover our selection of lipidated polyamino acids and custom capabilities. Read on to find out more!

Herein, we present building blocks for the synthesis of protected hydroxylamine derivatives which can be further used for bio-conjugation and various other applications. Read on to find out more!

Discover our selection of propargyl-substituted amino acids and find the best position for subsequent Click chemistry within your peptide/protein. Just click here for further information on our products.

Discover our selection of substrates for Halo-, Snap-, and Clip-tagged proteins bearing different terminal groups suitable for further functionalization, e.g. biotinylation and Click chemistry.

Herein we are reporting on the linker stability of amino-PEG-acids achieved via N-methylation and the possible side-reaction without this additional modification. Read on to find out more!

Typically known and employed as preformed dipeptides, we are presenting Serine- and Threonine-derived Pseudoproline monomers as building blocks for solid-phase peptide synthesis.

Check out our growing portfolio on adamantyl-substituted amino acids and building blocks. At Iris Biotech, we are constantly striving to improve our services, our products, and the routes of synthesis.

Discover the versatile applications of hydrazone resins e.g. for the preparation of peptide hydrazides, or the generation of peptide thio esters. Read on to find out more and see our available products.

Selenocysteine (Sec) plays a crucial role for various biological processes, and selenoproteins can be found in all lineages of life. Read on to discover the 21 st amino acid, its derivatives and applications.

Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.

Iris Biotech offers a variety of (functionalized) biotin and desthiobiotin reagents reactive towards certain functional groups. Discover our growing portfolio and latest additions.

Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which can be elongated by Fmoc-SPPS and can easily be linked to amino-functionalized solid supports. Read on to find out more about their advantages.

Interested in structure-activity studies of your Proline-containing peptide drug? Find out more about the use of Methanoprolines and Dimethylprolines as conformational amide locks.

Iris Biotech offers various (protected) azide- and alkyne-modified fatty acid derivatives suitable for Click Chemistry. Interested? Read on to find out more!

Serine- and Threonine-derived oxazolidines as well as Cysteine-derived thiazolidines, so-called Pseudoprolines, serve as structure-disrupting, solubilizing building blocks in peptide synthesis.

Read on to find out more about Iris Biotech’s Linkerology® portfolio including substituted pyridyldithiols as building blocks for the reversible chemical conjugation to sulfhydryls.

Interested in studying the effect of palmitoylation on your peptide’s localization, function, and stability? Read on to find out more about the use of lipidated “fatty” amino acids!

Interested in structure activity studies on your Arginine containing peptide or further optimization for improved receptor binding? Explore our guanidino Proline derivatives as rigid Arginine mimics.

Herein we present substituted diazacyclononynes (DACNs) as versatile tools for metal-free strain-promoted Click Chemistry that are characterized by high reactivity and stability, both thermally and chemically.

Fmoc-Asp(CSY)-OH – an innovative building block to suppress aspartimide formation during peptide synthesis by utilizing cyanosulfurylide as carboxylic acid protecting group. Read on to find our more!

The highly lipophilic, bulky adamantyl motif is a promising and validated building block to increase the drug-qualities of lead compounds without increasing their toxicity.

Herein, we present aminooxy-amino acids reported for peptide synthesis via oxime ligation, cyclization via oxime formation, derivatization e.g. by glycosylation, or chelation. Read on to find out more.

The new disulfide-based protecting group sec-isoamyl mercaptan (SIT) is fully compatible with Fmoc- and Boc-SPPS and can easily be removed reductively upon addition of dithiothreitol.

The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.

Enzymatically-activatable probes based on 7-amino-4-methylcoumarin (AMC) represent versatile tools for the detection and localization of proteolytic enzyme activities. Read on to find out more.

Methionine is particularly prone to oxidation by atmospheric oxygen in vitro but also by reactive oxygen species in vivo, resulting in the corresponding sulfoxide and sulfone. Read on to find out more.

Mpro is a key enzyme of coronaviruses (coronaviridae) and thus an attractive drug target. Iris Biotech offers fluorescent substrates, which can be used to perform various types of screenings and to identify potential inhibitors of COVID-19.

Interested in histidine derivatives? Iris Biotech provides a selection of deamino- and decarboxy-products. Find out more about benefits and potential applications of our new building blocks.

Iris Biotech offers various linked kinase inhibitors including analogues of Gefitinib, Imatinib, Sunitinib, Staurosporine and many more, which can easily be conjugated to other biomolecules, if desired. Have a look and read more.

Iris Biotech presents its selection of Val-Cit-based linkers, a dipeptide motif frequently utilized for the development of ADCs with increased serum stability and high cleavage efficiency.

Iris Biotech presents the next-generation of hydrolysis-stable phosphono-analogs of pSer, pThr and pTyr. Fluorination renders the phosphonic acid more acidic and thus an even better mimic of the parent phosphoamino acid.

Isopropyl-β-D-thiogalactopyranoside (IPTG) is one of the most commonly utilized reagents in molecular biology.

Find out more about those building blocks with side chains able to coordinate metal ions, and why peptide-based HDACis are intriguing synthetic targets.

Amongst various somatostatin analogues, the pentacyclic heptapeptide TT-232 bears unique properties. Iris Biotech offers TT-232 as triacetate and trifluoroacetate salt, respectively, as well as conjugated to either biotin or the fluorophore indocyanine green.

Alkyne amino acids allow for Click conjugations and other types of chemistry. Read more about alkyne-functionalized amino acids and our related products.

The integrin receptor interacting RGD sequence and related peptides act as promising tools for drug therapy and cancer research. Find more information on our portfolio of cyclic RGD peptides.

The tremendous success of Liraglutide and Semaglutide has moved amino acids modified with lipids into the focus of many research endeavors. Delve into the treasure trove of our lipidated amino acids!

Arginine, a semi-essential amino acid, is involved in various important metabolic processes.

Proximity labeling of proteins with biotin-phenol (biotin-tyramide) and an engineered peroxidase enzyme (e.g. APEX = Engineered Ascorbate Peroxidase) is a pivotal tool for molecular biology.

8 - 13 September 2019

5 - 7 September 2019

Protease inhibitors are molecules that inhibit protease function by binding either reversibly or irreversibly to the enzyme.

o -Nitroveratryloxycarbonyl (Nvoc) is a photocleavable side chain protecting group for lysine that can be removed by irradiation with UV light (350 nm).

Succinylation of proteins on the epsilon-amino group of lysine residues is a posttranslational modification that is still poorly understood.

The 2D monolayer cell culture model is widely applied for drug screening. However, this approach is frequently not able to adequately mimic the in vivo response.

Phosphorylation of serine, threonine and tyrosine is counted among the most important posttranslational modifications that occur in organisms.

Iris Biotech introduces a comprehensive set of photo-crosslinking amino acids bearing the diazirine moiety.

You can pay by bank transfer. US customers can pay by credit card (Visa, Master).

Of course, Iris Biotech is aiming to deliver your products as fast as possible. The following table provides an overview of general delivery times for products which are on stock and are not counted as dangerous goods. Stock Items Delivery Destination Germany Europe Worldwide Delivery Time 1 Day 1-2 Days Around 2-5 Days Although smaller quantities of dangerous goods can often be delivered just as fast as substances that are not declare...

Polyarginines are well known for their ability to enhance cell penetration.

This alkyne-functionalized cysteine building block can be incorporated into peptides via the Fmoc strategy.

One role of proline in proteins is that a β-turn of a peptide chain is being induced at its position. Two major conformations, cis or trans, of the corresponding amid bond will induce that the protein folds in a specific way.

25 - 28 June 2017

Mercapto-PEG-Acids are highly hydrophilic, non-antigenic, non-immunogenic and non-toxic.

Azido and alkyne functions can cyclise by an intramolecular CuI or Cu0 catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC). This so-called Click Reaction, developed by K. Barry Sharpless and Morton Meldal, has meanwhile grown to a widely used type of reaction orthogonal to many other types of reactions in different kinds of applications.

a) Catalyst-free Click Reaction Cycloaddition reactions such as the [3+2] azide-alkyne and the [4+2] Diels-Alder reaction, are becoming common conjugation techniques. Applications range from imaging, drug design and development of sensors, thereby spanning the fields of chemical biology, material science, surface and polymer chemistry as well as many other fields. Introduced in 2002, the copper-catalyzed variant of the azide-alkyne cycloaddition (CuAAC) reaction has found broad applicability in t...

Mutant or modified aminoacyl tRNA synthetases (aaRS) have been used to charge non-natural amino acids to the corresponding tRNA, which incorporates them into polypeptides or proteins during recombinant synthesis.

Protein and lipid glycosilation is a life-governing and omnipresent process. Glycoconjugates display a multitude of biological effects from protein folding and stabilization, energy storage, cell surface interaction through molecular recognition motifs for cell-cell communication, and structural support and protection.

Click Chemistry in DNA Synthesis - Applications and Procedures in DNA Synthesis

Asymmetric Phase-Transfer Reaction Phase-transfer alkylations e.g. with the chiral Maruoka catalyst result in unique α-mono substituted and α,α-disubstituted unnatural amino acids.

Several platforms are available to display the whole assortment of homo-amino acids, as well as the higher homologues β2-, β3-, their double substituted derivatives β2,2,2-, β3,3-, and corresponding γ-amino acids.

The variations for linkers are endless, as in our catalogue program already hundreds of different derivatives are available for conjugation of small molecules, biomolecules and surfaces to each other.

Polyamines such as ethylene diamine and its higher homologues are important feedstocks for the chemical industry. Compounds like putrescine, spermidine, and spermine play important roles in both eukaryotic and prokaryotic cells and show many other different biological functions.

Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.

10-13 October 2016 San Diego, CA, USA Marriot Marquis & Marina

The classic FRET pair EDANS and DABCYL is now available linked to Fmoc amino acid building blocks that can be readily used in SPPS. Conveniently synthesize your own custom protease substrates!

Omniligase-1 enables efficient and racemization-free ligation of two side-chain unprotected peptide fragments at many different positions. Test this innovative enzyme developed by EnzyPep B.V. using the complementary model peptides included in our kit!

Peptides as pharmaceutical compounds suffer from unfavorable pharmacokinetics which is, among other things, due to a slow uptake into cells and rapid proteolytic cleavage. N -Alkylation of peptides is a valuable tool to overcome these limitations. We now offer new kits that enable the facile preparation of peptoids and N -alkylated peptides.

The reaction between a tetrazine (Tz) and a trans -cyclooctene (TCO) is the innovative third generation Click reaction that proceeds without the use of copper or other catalyst. It is rapid, fully bioorthogonal and excels at very low concentrations.

Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.

2-Furyl-alanine can be incorporated into peptides via SPPS or by using enzymatic approaches. UV-irradiation in the presence of oxygen and a photosensitizer converts furyl-alanine to an intermediate that selectively reacts with certain nucleophiles. This property can be employed for site-specific labeling of peptides and proteins.

5-oxa-Derivatives of Orn and Arg, respectively, these rare amino acids are produced by legumes as protection against herbivores. For your convenience, we offer building blocks of both amino acids compatible with standard Fmoc/ t Bu SPPS chemistry

N δ -hydroxy- N δ -acetyl-ornithine, an important constituent of many siderophores, is now available for your convenience as  N α -Fmoc- N δ -(acetyl)- N δ -(benzoyloxy)-ornithine  building block which can be used in standard Fmoc/ t Bu SPPS and permits facile on-resin  N δ -deprotection.

October 7 to 9 2015 Melbourne, Victoria, Australia https://www.ausbiotech.org/ AusBiotech represents 3000 members covering the human health, agricultural, environmental, industrial, medical device, functional foods and Investment sectors in biotechnology. Over 150 events for the life science sector provide unique networking opportunities through business matching programs, sponsorship and guest speaker roles.

October 22 to 25, 2015 Ramada Couran Cove Island Resort, South Stradbroke Island, Queensland, Australia http://solidphase.org The symposium provides a superb opportunity for all practitioners of solid phase peptide synthesis together with those who use synthetic peptides for a myriad of applications to congregate at the beautiful Couran Cove Resort, South Stradbroke Island, a short ferry ride from the famed Gold Coast of Queensland .

October 25 to 30, 2015 Peppers Salt & Spa, Kingscliff, NSW, Australia http://www.ozpeptide.org/australian-peptide-conference-2015/australian-peptide-conference-2015/ In the 11th Australian Peptide Conference with typically some 200+ delegates the theme 'Peptide Discovery and Development' will address cutting edge areas of peptide and small protein research including: new bioactive peptides, advances in peptide and protein synthesis, target receptors and GPCRs, structure-based drug design, transc...

Oligo-glycines are either flexible linkers or form well defined rigid substructures. We offer a variety of oligo-glycines as building blocks which can easily be introduced into any molecule.

Surprising behavior of NXO-peptides. It is a significant property of peptides that oxalo-retro azapeptides have the same donor and acceptor distances and properties for hydrogen bridge formation as a tripeptide fragment and therefore induce beta-sheet formation at this position.

July 1st - 3rd, 2015 Université d’Avignon et des Pays de Vaucluse Avignon, France RICT 2015 - the 51st edition of the International Conference on Medicinal Chemistry - is expected to gather 550-600 scientists from around the world, with a majority of scientists coming from Europe. The scientific programme, which will include over 25 plenary lectures by internationally well-known scientists, will focus on " Drug Discovery and Selection - Understanding Targets and Mechanisms ", coverin...

June 10th - 12th, 2015 Reitoria of Universidade Nova de Lisboa Campus de Campolide, Lisboa, Portugal The 6th European Conference on Chemistry for Life Sciences (6th ECCLS) will be held in Lisbon, Portugal, in June 10-12, 2015. Lisbon meeting will be sixth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009), Budapest (2011) and Barcelona (2013) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge between chemi...

We at Iris Biotech, are pleased to announce that we have entered into an agreement with Peptide Solutions, LLC to sell the complete line of our products in the USA and Canada. Peptide Solutions’ website has a link to our complete list of products so ordering online is extremely easy, however, personal contact is available at the phone listed above, Monday through Friday, 8am to 5pm MST.

Pseudoprolines derived from Serine and Threonine have developed to standard building blocks for peptide synthesis since their invention. Now this technology is also available with Cysteine residues, as the corresponding 2,4-dimethoxyphenyl-pseudothiaproline is compatible with standard Fmoc/tBu protocols.

Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.

Fatty Acids for Click Conjugation Fatty acid residues and alkyl chains in general can improve solubility and anchoring in membranes and other Lipophilie environments. Find a selection of promptly available short and long chain clickable acids in our web store. Any other – including functional groups for copper-free Click conjugation can be made on custom synthesis basis.

1,4-substituted 1,2,3-triazole are isosteric to peptide bonds and result in peptide mimetics which even retain activity e.g. in case of certain tyrosinease inhibitors. We offer custom synthesis of Alkyne Amino Acid Analogues as building blocks for triazol formation via Click conjugation. Side chains can represent all natural amino acids or unusual residues. In combination with our alpha-azido acids we can offer the whole range of building blocks to design Click-peptide bond analogues for every proteinoge...

The presence of catalytic copper, limits the in vivo application of the Click this reaction for several reasons. We offer custom synthesis of Strained Cyclooctynes and Substituted 1,2,4,5- Tetrazines as building blocks for fast Click reactions in the absence of any catalyst.

GABA is a neurotransmitter in the central nervous system of mammals and its deficiency is associated with severe neurological disorders. Statine, a GABA analogue, occurs in several peptide APIs. Derivatives of gamma-amino acid analogues are of continued vital interest for a variety of applications in medicinal chemistry. We have a tool box available to offer a broad range of substituted gamma-amino acids and statines on custom synthesis basis.

Benzotriazol activated carboxylic acids: Fast reaction (within minutes) at room temperature with amines and other nucleophiles under addition of base (in both water and non- aqueous solvents). Stable to racemization when coupling with nucleophiles. High solubility in organic solvents like DMF and DCM. Stable in water.

In modern biotechnology there are numerous applications for the luminogenic luciferase assay. We supply luciferin from mg scale for research applications like monitoring of gene expression or tumor growth up to kg quantities for hygiene surveillance in food industry

May 28th - 30th, 2014 KINTEX, Exhibition Center II Kintex, Korea BIO KOREA 2014 Conference is a worldwide accepted venue and place to discuss and acquire the cutting edge knowledge on various topics including vaccines, clinical trials, regenerative medicine, bio energy, GMO, functional food, technology transfer and licensing to firmly secure the global competitiveness.

Arginine rich peptides show increased interest during the last years as they have the capability to cross cell and blood brain barrier membranes.

May 19th - 21th, 2014 Centro de Investigación Príncipe Felipe Valencia, Spain Unlike other Drug Delivery Symposia that have a broader remit, this unique conference series was specifically established to provide a forum for interdisciplinary exchange of state-of-the-art techniques and advances in knowledge relating to the design, clinical development and commercialisation of Polymer Therapeutics. The key topics discussed during the 10th International Symposium on Polymer Therapeutics are...

Compounds like putrescine, spermidine, and spermine play important roles in a many biological functions. Many of them are excellent targets for oncology studies and other fields of medicinal chemistry. Find in our new brochure Diamines & Polyamines our possibilities for custom synthesis and a set over 100 available derivatives.

June 10th-12th, 2013 Auditorio AXA Barcelona, Spain Barcelona meeting will be fifth in a series – after Rimini (2005), Wroclaw (2007), Frankfurt (2009) and Budapest (2011) – and will put together scientists from different backgrounds in order to facilitate translation of knowledge from chemistry to biology. 

Long-chain acylcarnitines are well-known intermediates in mitochondrial fatty acid oxidation

A prominent luciferase group was first discovered in Coelenterata and the corresponding light emitting molecule was therefore named coelenterazine.

March, 29th - 31th, 2012 Mosbach, Germany Once again outstanding scientists will present their work focussed on Posttranslational Modifications at the Mosbacher Kolloquium. Under the headline "Post-translational modifications in signal integration and molecular Therapies" the Kollogium will be an interesting event.

Spermines and other Biogenic Polyamines interact due to their multi cationic structure with DNA!

October 2 - 6, 2011 ITALY - ATAHOTEL NAXOS BEACH RESORT, Giardini Naxos (Messina) Sicily ( http://www.biotrans2011.org/ )

Mal-AMCHC-OSu trans-N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate Formula:                    C 16 H 18 N 2 O 6 Molecular Weight:     334,33 g/mole CAS:  64987-85-5 CODE:  MAA1000 1g:       EUR    300,-    US$   420,- 5g:       EUR  1200,-  ...

PGA (Penicillin G Amidase, Penicillin Acylase, Penicillin Amidohydrolase from E.coli on acrylic resin, Systematic name: Penicillin amidohydrolase, E.C. 3.5.1.11) has an active pocket, which is very specific for phenyl acetic acid. The prominent commercial use is hydrolysis of a phenylacetamid bond during production of the penicillin API 6-APA (De Martin et al., J. Mol. Catal. B:Enzymatic 1999; 6: 437). The high specifity of PGA towards the Phenylacetyl moiety makes the use of Phacm as new alternative ...

Dendrimers offer a new possibility to derivatize small molecules, surfaces or biopharmaceuticals with a monodisperse macromolecule and alter in this way properties like solubility and hydrophilicity. Immunogenicity and pharmacokinetics of pharmaceuticals will be improved. The synthetic approach for designing these dendrons of different generations is based on 2,2-bis(hydroxymethyl) propionic acid, which is a non-toxic and biocompatible building block. The size can be designed from 250 g/mole for 1st gene...

Abstract: A considerable number of biologically active naturally occurring products are peptides, depsipeptides, and peptide conjugates.

Chiara Carboni, Hans G. T. Kierkels, Lucia Gardossi, Kamil Tamiola, Dick B. Janssen and Peter J. L. M. Quaedflieg Tetrahedron Asymmetry: 2006; 17 : 245–251 https://doi.org/10.1016/j.tetasy.2005.12.023     Abstract: We have demonstrated for the first time that D-glutamine (D-Gln) and D-glutamic acid (D-Glu) can be efficiently obtained in high ee (97% and 90%, respectively) by enzymatic kinetic resolution of D,L-Gln and D,L-Glu. This was achieved by enantioselective conversion of...