Novel amino-Li resin for water-based solid-phase peptide synthesis

Novel amino-Li resin for water-based solid-phase peptide synthesis

Published on 17/07/2024

Amino-Li resin – a cross-linked polyacrylic amide solid support suitable for the synthesis of peptides and biomolecules, which is compatible with organic as well as aqueous solvents. 

Novel amino-Li resin for water-based solid-phase peptide synthesis

Abstract: We report the first application of a novel amino-Li resin to water-based solid-phase peptide synthesis (SPPS) applying the Smoc-protecting group approach. We demonstrated that it is a suitable support for the sustainable water-based alternative to a classical SPPS approach. The resin possesses good swelling properties in aqueous milieu, provides significant coupling sites, and may be applicable to the synthesis of difficult sequences and aggregation-prone peptides.

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