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Halo-PEG(2)-Suc
Chemical name: 4-((2-(2-((6-chlorohexyl)oxy)ethoxy)ethyl)amino)-4-oxobutanoic acid // Synonyms: Haloalkane Dehalogenase Ligand
- Product code:RL-3180
- CAS No.:1488363-39-8
- Formula:C14H26ClNO5
- Storage temperature:RT
- Molecular weight:323.81 g/mol
from $250.00
description
This chloroalkane linker is a ligand for a specific modified bacterial haloalkane dehalogenase, also known as HaloTag®. The linker can be used for the chloroalkane penetration assay (CAPA), a quantitative and compartment-specific cell penetration assay for peptides and other potential biotherapeutics.
Further applications of the HaloTag® technology include cellular imaging as well as protein immobilization. Those applications can be accessed via an appropriate modification of the linker's carboxyl terminus, e.g. with an amine-functionalized fluorophore.
references
Oligomers of Cyclic Oligochalcogenides for Enhanced Cellular Uptake; R. Martinent, D. Du, J. López-Andaria, N. Sakai, S. Matile; ChemBioChem 2021; 22: 253-259. https://doi.org/10.1002/cbic.202000630.
Macropinocytosis as a Key Determinant of Peptidomimetic Uptake in Cancer Cells; D. Y. Yoo, S. A. Barros, G. C. Brown, C. Rabot, D. Bar-Sagi, P. S. Arora; J. Am. Chem. Soc. 2020; 142(34): 14461-14471. https://doi.org/10.1021/jacs.0c02109.
Covalently Tethered Rhodamine Voltage Reporters for High Speed Functional Imaging in Brain Tissue; P. E. Deal, P. Liu, S. H. Al-Abdullatif, V. R. Muller, K. Shamardani, H. Adesnik, E. W. Miller; J. Am. Chem. Soc. 2020; 142(1): 614-622. https://doi.org/10.1021/jacs.9b12265.
Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment; I. Takashima, K. Kusamori, H. Hakariya, M. Takashima, T. H. Vu, Y. Mizukami, N. Noda, Y. Takayama, Y. Katsuda, S.-I. Sato, Y. Takakura, M. Nishikawa, M. Uesugi; ACS Chem. Biol. 2019; 14(4): 775-783. https://doi.org/10.1021/acschembio.9b00109.
Cell Penetration Profiling Using the Chloroalkane Penetration Assay; L. Peraro, K. L. Deprey, M. K. Moser, Z. Zou, H. L. Ball, B. Levine, J. A. Kritzer; J. Am. Chem. Soc. 2018; 140(36): 11360-11369. https://doi.org/10.1021/jacs.8b06144.
Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy; L. Peraro, Z. Zou, K. M. Makwana, A. E. Cummings, H. L. Ball, H. Yu, Y.-S. Lin, B. Levine, J. A. Kritzer; J. Am. Chem. Soc. 2017; 139(23): 7792-7802. https://doi.org/10.1021/jacs.7b01698.
Optogenetic control of kinetochore function; H. Zhang, C. Aonbangkhen, E. V. Tarasovetc, E. R. Ballister, D. M. Chenoweth, M. A. Lampson; Nat. Chem. Biol. 2017; 13(10): 1096-1101. https://doi.org/10.1038/nchembio.2456.
Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging; Chem. Commun. 2016; 52: 160-163. https://doi.org/10.1039/C5CC06565H.
Bifunctional Molecules beyond PROTACs; S. J. Conway; Journal of medicinal chemistry 2020; 63: 2802-2806. doi: https://doi.org/10.1021/acs.jmedchem.0c00293
Cell Penetration Profiling Using the Chloroalkane Penetration Assay; L. Peraro, K. L. Deprey, M. K. Moser, Z. Zou, H. L. Ball, B. Levine and J. A. Kritzer; J Am Chem Soc 2018; 140: 11360-11369. doi: https://doi.org/10.1021/jacs.8b06144
HaloTag technology: a versatile platform for biomedical applications; C. G. England, H. Luo and W. Cai; Bioconjug Chem 2015; 26: 975-86. doi: https://doi.org/10.1021/acs.bioconjchem.5b00191
HaloTag: a novel protein labeling technology for cell imaging and protein analysis; G. V. Los, L. P. Encell, M. G. McDougall, D. D. Hartzell, N. Karassina, C. Zimprich, M. G. Wood, R. Learish, R. F. Ohana, M. Urh, D. Simpson, J. Mendez, K. Zimmerman, P. Otto, G. Vidugiris, J. Zhu, A. Darzins, D. H. Klaubert, R. F. Bulleit and K. V. Wood; ACS Chem Biol 2008; 3: 373-382. doi: https://doi.org/10.1021/cb800025k
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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