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Leupeptin Hemisulfate
Chemical name: N-Acetyl-L-leucyl-L-leucyl-L-argininal hemisulfate salt // Synonyms: Acetyl-Leu-Leu-Arg-al
- Product code:LS-3900
- CAS No.:103476-89-7
- Formula:C20H38N6O4 * 1/2H2SO4
- Molecular weight:475.59 g/mol
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description
A potent, reversible inhibitor of serine and cysteine proteases that shows little to no inhibitory activity against pepsin, cathepsins A and D and alpha-chymotrypsin.
references
Active and inactive forms of the transition-state analog protease inhibitor leupeptin: explanation of the observed slow binding of leupeptin to cathepsin B and papain; R. M. Schultz, P. Varma-Nelson, R. Ortiz, K. A. Kozlowski, A. T. Orawski, P. Pagast and A. Frankfater; J Biol Chem 1989; 264: 1497-507.
Inhibition of thrombin-induced platelet activation by leupeptin. Implications for the participation of calpain in the initiation of platelet activation; L. F. Brass and S. J. Shattil; J Biol Chem 1988; 263: 5210-6.
Successful treatment of murine muscular dystrophy with the proteinase inhibitor leupeptin; J. H. Sher, A. Stracher, S. A. Shafiq and J. Hardy-Stashin; Proc Natl Acad Sci U S A 1981; 78: 7742-4.
Letter: A thermolysin inhibitor produced by Actinomycetes: phospholamidon; H. Suda, T. Aoyagi, T. Takeuchi and H. Umezawa; The Journal of antibiotics 1973; 26: 621-3.
Inhibition of tumorigenesis in mouse skin by leupeptin, a protease inhibitor from Actinomycetes; M. Hozumi, M. Ogawa, T. Sugimura, T. Takeuchi and H. Umezawa; Cancer Res 1972; 32: 1725-8.
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