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Halo-PEG(2)-Azide
Chemical name: 1-Azido-12-chloro-3,6-dioxadodecane // Synonyms: 1-(2-(2-Azidoethoxy)ethoxy)-6-chlorohexane
- Product code:RL-3700
- CAS No.:2568146-55-2
- Formula:C10H20ClN3O2
- Storage temperature:-20°C
- Molecular weight:249.74 g/mol
from $375.00
description
This chloroalkane linker serves as ligand for a specific modified bacterial haloalkane dehalogenase. This is a reporter protein whose sequence can easily be fused to a gene of interest. The reaction between the chloroalkane linker and the enzyme is fast and irreversible under physiological conditions and the system has been used extensively to measure protein-protein interactions in cells.
Furthermore, the additional azide moiety serves clickable moiety.
references
HaloTag technology: a versatile platform for biomedical applications; C. G. England, H. Luo and W. Cai; Bioconjug Chem 2015; 26: 975-86. https://doi.org/10.1021/acs.bioconjchem.5b00191.
HaloTag: a novel protein labeling technology for cell imaging and protein analysis; G. V. Los, L. P. Encell, M. G. McDougall, D. D. Hartzell, N. Karassina, C. Zimprich, M. G. Wood, R. Learish, R. F. Ohana, M. Urh, D. Simpson, J. Mendez, K. Zimmerman, P. Otto, G. Vidugiris, J. Zhu, A. Darzins, D. H. Klaubert, R. F. Bulleit and K. V. Wood; ACS Chem Biol 2008; 3: 373-382. https://doi.org/10.1021/cb800025k.
HaloTag-Targeted Sirtuin-Rearranging Ligand (SirReal) for the Development of Proteolysis-Targeting Chimeras (PROTACs) against the Lysine Deacetylase Sirtuin 2 (Sirt2); M. Schiedel, A. Lehotzky, S. Szunyogh, J. Oláh, S. Hammelmann, N. Wössner, D. Robaa, O. Einsle, W. Sippl, J. Ovádi, M. Jung; ChemBioChem 2020; 21(23): 3371-3376. https://doi.org/10.1002/cbic.202000351.
Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells; B. Cai, D. Kim, S. Akhand, Y. Sun, R. J. Cassell, A. Alpsoy, E. C. Dykhuizen, R. M. Van Rijn, M. K. Wendt, C. J. Krusemark; J. Am. Chem. Soc. 2019; 141(43): 17057-17061. https://doi.org/10.1021/jacs.9b08085.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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