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Boc2NOH
Chemical name: Di-tert-butyl hydroxyiminodicarbonate // Synonyms: Tert-butyl N-[(tert-butoxy)carbonyl]-N-hydroxycarbamate, Bis-N-Boc-hydroxylamine, Di-Boc-hydroxylamine, N,N-bis-Boc-hydroxylamine, N,N-Di(Boc)hydroxylamine
- Product code:RL-3660
- CAS No.:142654-29-3
- Formula:C10H19NO5
- Molecular weight:233.26 g/mol
- Purity :min. 98%
from $105.00
description
This reagent can be used to synthesize various protected hydroxylamine derivatives that can be used for bio-conjugation and other applications.
references
Rapid Synthesis of Alkoxyamine Hydrochloride Derivatives from Alkyl Bromide and N,N’-Di-tert-butoxycarbonylhydroxylamine [(Boc)2NOH]; P. S. Jayasekara, K. A. Jacobson; Synth. Commun. 2014; 44: 2344-2347. https://doi.org/10.1080/00397911.2014.895014.
In situ growth of a stoichiometric PEG-like conjugate at a protein’s N-terminus with significantly improved pharmacokinetics; W. Gao, W. Liu, J. A. Mackay, M. R. Zalutsky, E. J. Toone, A. Chilkoti; PNAS 2009; 106(36): 15231-15236. https://doi.org/10.1073/pnas.0904378106.
4-Alkyloxyimino Derivatives of Uridine-5’-trphosphate: Distal Modification of Potent Agonists as a Strategy for Molecular Probes of P2Y2, P2Y4, and P2Y6 Receptors; P. S. Jayasekara, M. O. Barrett, C. B. Ball, K. A. Brown, E. Hammes, R. Balasubramanian, T. K. Harden, K. A. Jacobson; J. Med. Chem. 2014; 57: 3874-3883. https://doi.org/10.1021/jm500367e.
Synthesis of Constrained Tetracyclic Peptides by Consecutive CEPS, CLIPS, and Oxime Ligation; D. E. Streefkerk, M. Schmidt, J. H. Ippel, T. M. Hackeng, T. Nuijens, P. Timmerman, and J. H. van Maarseveen; Org. Lett. 2019; 21(7): 2095-2100. https://doi.org/10.1021/acs.orglett.9b00378.
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