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Biotin-Clip
Chemical name: N-(4-(((4-aminopyrimidin-2-yl)oxy)methyl)benzyl)-6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamide // Synonyms: Biotin-BC, Biotin-Benzylcytosine
- Product code:RL-3870
- CAS No.:1004524-73-5
- Formula:C28H39N7O4S
- Storage temperature:2-8°C
- Molecular weight:569.73 g/mol
from $250.00
description
Biotin conjugated benzylcytosine (BC). The BC moiety reacts specifically and rapidly with the so-called CLIP-tag, a polypeptide protein tag, allowing irreversible and covalent labeling of clip fusion proteins with biotin. Biotinylated proteins can for example be selectively isolated based on the high affinity towards avidin representing a useful tool for purification, immobilization, and labeling.
references
A general method for the covalent labeling of fusion proteins with small molecules in vivo; A. Keppler, S. Gendrezig, T. Gronemeyer, H. Pick, H. Vogel, K. Johnsson; Nat. Biotechnol. 2003; 21: 86-89. https://doi.org/10.1038/nbt765.
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