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Product of the month
Herein we highlight products which we consider to be of special interest to our customers.
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New Substituted Ornithine Derivatives
l-Ornithine derivative containing peptides play important roles in SAR studies, enzyme inhibition and cancer research. We now offer a variety of Nδ-substituted ornithines containing heterocyclic, aromatic and aliphatic groups, as well as N-substituted C3- and C4-analogs of ornithine.
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NGlyO – for beta sheet formation
Surprising behavior of NXO-peptides.
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It is a significant property of peptides that oxalo-retro azapeptides have the same donor and acceptor distances and properties for hydrogen bridge formation as a tripeptide fragment and therefore induce beta-sheet formation at this position.
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NEW Hydrazone Resin
A new hydrazone resin enables a convenient way to synthesize peptide hydrazides for Hydrazone Ligation Technique and Native Chemical Ligation (NCL).
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Stable Conjugation with Thiols
Maleimide (MAL) reacts rather specific with free thiol groups and forms appropriate conjugates. However, this reaction is slightly reversible, resulting in loss of the conjugation partner.
Amino functions open the maleimido ring structure through hydrolysis with nucleophilc neighboring effect and thus inhibit the undesired release reaction.
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Polar Amino Acids for Increased Solubilization
alpha-Sulfo-beta-Alanine has been used to couple to hydrophobic molecules and peptides and increase solubility. Attachment can be carried out by conventional Fmoc/tBu protocols.
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Custom Synthesis of Alkyne Amino Acids Analogues for Click Conjugation
1,4-substituted 1,2,3-triazole are isosteric to peptide bonds and result in peptide mimetics which even retain activity e.g. in case of certain tyrosinease inhibitors.
We offer custom synthesis of Alkyne Amino Acid Analogues as building blocks for triazol formation via Click conjugation. Side chains can represent all natural amino acids or unusual residues. In combination with our alpha-azido acids we can offer the whole range of building blocks to design Click-peptide bond analogues for every proteinogenic amino acid.
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Luciferin for Research and Industry – from MG to KG Scale
In modern biotechnology there are numerous applications for the luminogenic luciferase assay. We supply luciferin from mg scale for research applications like monitoring of gene expression or tumor growth up to kg quantities for hygiene surveillance in food industry
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Bis-Boc-guanidinopyrazole
Arginine rich peptides show increased interest during the last years as they have the capability to cross cell and blood brain barrier membranes.
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Bis-Mal-Lysine
Bis Thiol & Amine reactive PEGylated Cross-Linker which has been used for enhanced receptor binding, for the design of long-acting conjugates for type 2 diabetes therapeutics and in reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators.
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Phthalimidooxy PEG-based cross linkers
Phthalimidooxy PEG-based cross linkers form stable oximes with aldehydes, also latent ones as present in carbohydrates. Their reactivity is sufficiently mild for a broad used in creating conjugates with sensitive biologics.
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