Fmoc-L-Asn(EDA-N3)-OH

Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-gamma-(2-azidoethyl)-L-asparagine // Synonyms: Fmoc-Asn(EDA-N3)-OH, Fmoc-Asn-Azide, Fmoc-Asn-N3, N-alpha-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-gamma-(2-azidoethyl)-L-asparagine

  • Product code:FAA8605
  • CAS No.:2616562-74-2
  • Formula:C21H21N5O5
  • Storage temperature:2-8°C
  • Molecular weight:423.43
  • Purity :min. 98%
  • Enantiomeric Purity:min. 99,7%

from €162.00

Grouped product items
Qty Packing unit Price SKU Availability
500 mg
€162.00
FAA8605.0500
Please inquire
1 g
€252.00
FAA8605.1000
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5 g
€900.00
FAA8605.5000
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25 g
€3,600.00
FAA8605.9025
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Safety Data Sheets
description

This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 µg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II.


references

Scaling amatoxin synthesis with an improved route to (2S,3R,4R)-dihydroxyisoleucine exemplified by a toxic, clickable alpha-amanitin analog; C. M. Hambira, K. Matinkhoo, A. Pryyma, B. O. Patrick, D. M. Perrin; J. Org. Chem. 2021, 86(7): 5362-5370. https://doi.org/10.1021/acs.joc.0c03022.

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