Search results for: 'thi all'

A Triazolecarbaldehyde for Selective N-Terminal Protein Modification

Looking for methods to selectively modify your peptide’s N-terminus?...

PotM: Furan-Crosslinking and 5HP2O as Maleimide Alternative

Game Changer for Protein Modification: Discover oxidation-induced furan...

A Fluorescent Probe for “Hard and Soft” Reactive Metabolites

Discover CysGluDan, a new fluorescent probe for the detection of reactive...

Chain Extension: Discover Homo Amino Acids

We expanded our portfolio of Fmoc-protected homo amino acids. Benefit of...

HMPO: A pH-Responsive Linker for Targeted Drug Delivery

HMPO (5-(hydroxymethyl)pyrogallol orthoester), a plasma-stable, pH-sensitive,...

PotM: MYTsA – A Novel Ynamide Coupling Reagent

Discover MYTsA as coupling reagent for peptide synthesis in “traditional”...

Hidden Champion – The Tetrahydropyranyl Protective Group

Tetrahydropyranyl (THP) is an excellent protective group for hydroxy and...

Common Side Reactions in Fmoc Solid-Phase Peptide Synthesis

Collect information about the most common side reactions during Fmoc SPPS and...

GGFG Motif for ADC Construction

To address both chemical and IP considerations in self-immolating linker...

PotM: Versatile TentaGel® Resins

Discover the diversity of TentaGel® Resins! Read our blog to get more...

About the Evolution of RNA and Peptides

Where does life come from and how can we simulate early earth conditions...

Product Availability Displayed on Website

Green – Yellow – Red – Grey. To increase transparency in terms of...

PotM: Cyclover-Amine for Peptide and Oligonucleotide Synthesis

Cyclophase Synthesis - Dissolve. React. Precipitate. Filter. Repeat! Make...

Bioisosteric Argininine Analogs

Same but different! Expand your possibilities for peptide modification and...

Protecting Groups in SPPS

Mix & Match. Discover typically employed protecting groups used to...

Amino-Li Resin – A Novel Solid Support

Shaken, not stirred. Amino-Li resin – a cross-linked polyacrylic amide...

Latest Products 2024 (Part 1)

What’s new? Don’t miss innovative building blocks and latest technologies...

Deprotection and Coupling in SPPS

Get the most out of your synthesis! Monitor your deprotection and coupling...

PotM: Oleyl-Poly(Sarcosines) for Drug Delivery

Novel excipients can help you master the challenges associated with the...

Workshop: ALL FluorINE - About SCF­3 and other Fluorinated Amino Acids

You missed our workshop featuring Prof. Thierry Brigaud? Watch the Recording!

Bifunctional TentaGel® Resins

Encode beads with unique tags for combinatorial syntheses & screening....

Boc versus Fmoc for Solid Phase Peptide Synthesis

Wondering about the difference between Boc and Fmoc chemistry in solid phase...

Linkerology® for Targeted Delivery and Release

Use the possibilities of Linkerology® to boost the efficacy of your drug! We...

Norbornenes – Will You Click Me?

Proposing norbornenes – strained, bicyclic alkenes for fast, copper-free,...

PotM: About the Impact of Fluorinated Building Blocks

Clever Move - Add positive effects to your molecule by introducing the most...

Carboxymethyl Amino Acid Derivatives

Level up! Carboxymethyl-modified amino acid building blocks suitable for...

“Power On” – Activity Control by Photocaging

Discover photocages – photosensitive protecting groups that are removed by...

2-Cyanopyridines for Click-Like Reactions

Have an additional ace up your sleeve for selective and efficient peptide...

Aminothiols for Versatile Side-Chain Modification

Beyond cysteines: Unlock targeted side-chain modifications of your peptides...

Azobenzene Photoswitches

Engineer shape-shifting peptides, controllable by a laser as magic wand! In...

PotM: Oligomeric Sarcosine Building Blocks

You are looking for monodisperse Sarcosines? You want to use Sarcosine for...

Workshop : Fluorogenic Amino Acids for SPPS

You missed our workshop featuring Dr. Fabio de Moliner & Prof. Dr. Marc...

Phenylboronate Amino Acid Building Blocks

Boron is not boring at all! Today, we'll delve deeper into the exciting world...

Linkerology® - An Example of Advanced Conjugation

The targeted delivery and traceless release of drugs is an important concept...

Phenylisopropylester (OPP) as Carboxy Protecting Group

Explore phenylisopropylesters (OPP/OPis) as carboxy protecting groups....

PotM: Aminoprolines - Controlling the Folding

You are looking for a building block suitable to control the folding...

Fluorogenic Building Blocks for Peptide Guided Wash-Free Imaging

Live-imaging of dynamic structures and catching events in living cells is a...

PotM: Blockbuster Building Blocks

Are you keen on developing novel billion-dollar-selling peptide API...

A Tetrazole-Substituted Lysine as PTM Isostere

The tetrazole isostere of malonyllysine is thermally stable and does not...

Tougher Restrictions on DMF

REACH regulation for the handling of N,N-dimethylformamide (DMF), the most...

PotM: SCF3 in One

Increase your peptide’s stability, introduce an NMR label for analysis, or...

Review – Product Highlights 2023

Curious about the highlights of our 2023 portfolio additions? Discover...

Combination Therapy & Linkerology®

Discover possibilities to fight chronic pain diseases by employing linker...

Glycosylated Asparagine Building Blocks for SPPS

Add glycans to your proteins with our ready-to-use Fmoc asparagine building...

Automated Peptide Synthesis

The discovery of the Merrifield peptide synthesis paved the way for automated...

PotM: Small-sized, neutral fluorogenic amino acids suitable for SPPS

Discover our small-sized, neutral Fmoc-protected nitrobenzoselenadiazole- and...

PotM: Next Generation Lysine Side Chain Protecting Groups

Sick of Lysine side chain protecting groups jumping around, yielding...

Linkerology® on Metal & Ore Surfaces

A heart of gold! Metals and ores - see here how their surfaces can be...

Process Development – From Discovery to Scale-up

Ongoing research efforts lead to the discovery of innovative building blocks...

Selective Lysine Labeling with Squaric Acid

Keeping control! PEGylating reagents with a squaric acid ethyl ester react...

PotM: Multiconjugates via Simultaneous Double-Click Reaction

Discover our new building block 4-(azido-propyl-tetrazine)phenylalanine...

Conjugating Small Molecule Drugs

You want to attach your small molecule to a certain carrier? Let’s analyze...

Cell-Free Bioengineering & Linkerology®

Bioengineering in combination with Linkerology®. Check out the unique...

PotM: TCEP as Versatile Reducing Agent

TCEP is an effective reductant for disulfide bonds and a versatile reagent...

Conjugating Natural Products (3)

The potential of natural products of daily life, such as 6-shogaol from...

Functionalization of Carbon Materials by Linker Attachment

Allotropes of carbon show distinct characteristics in structure and e.g....

Cyanobenzothiazole (CBT) Derivatives for “Click” Conjugation

Discover the cyanobenzothiazole (CBT) click reaction, a not (yet) so...

Review – Product Highlights 2023 (Part 1)

Curious about our latest portfolio additions from January to June 2023?...

PotM: Safety Catch - Orthogonally Protected Amino Acids

Add a new dimension of orthogonality to your peptide synthesis by using...

Photoaffinity Labeling by Diazirine Building Blocks

Discover our diazirine-substituted building blocks suitable for the analysis...

Functionalization of (Inert) Polymeric Surfaces

Plasma technology allows to equip inert polymers such as poly(ethylene) or...

Workshop Innovations in Click Chemistry

You missed our workshop featuring Prof. Rob Liskamp (Cristal Therapeutics,...

Carbamidomethylated Cysteine as SPPS Building Block

Our building block Fmoc-L-Cys(Cam)-OH enables peptides resembling reduced and...

Fluorogenic Protease Substrates with Enhanced Signal-to-Noise-Ratio

Shine bright like our fluorophores! Learn how our superior fluorogenic...

Conjugating Natural Products (2)

Infinite like the deep sea – marine natural products are an infinite source...

CliCr® - a Reactive and Soluble Bioorthogonal Click Reagent

Building blocks with a strained triple bond do not require copper catalysis...

Fatty Di-Acids

Peptide therapeutics – fewer injections/lower doses by prolonging their...

PotM: Limited Offer - Polysarcosine Bundles

From beginning of May until end of July 2023 we offer special polysarcosine...

Conjugating Natural Products (1)

From evolution to solution - natural products are an infinite source of...

PotM: Functionalized Dextrans

Our monofunctionalized dextrans are enriching the toolbox of polymer...

Non-canonical Tryptophan Derivatives

Non-canonical Tryptophan analogs can help to improve your API’s performance...

Coupling Reagents

Coupling Reagents are required for the formation of an amide or ester bond....

Workshop Protein Semi-Synthesis to Study Posttranslational Modifications

You missed our workshop featuring Prof. Christian F. W. Becker (University of...

Maleimide Crosslinkers

Maleimides provide versatile options for connecting payloads to proteins and...

PotM: Perfluorobiphenyl Building Blocks for Site-Selective Cysteine Conjugation

Herein, we present functionalized perfluorobiphenyl building blocks which can...

Amino-PEG-Acids

PEGs are being used as spacers, as hydrophilic decoration, and building...

PotM: Argpyrimidine Building Block for SPPS

Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic...

Choose your Taste – Functionalized Halo/Snap/Clip Substrates

The HaloTag®, SNAP-Tag® and CLIP-TagTM represent versatile tools for the...

Temporary Activity Masking via Self-Immolative Linkage

(Bi)functional dioxoborolane and disulfide-based self-immolative linkers –...

Let’s Talk Iris

You want to get an overview about the different Click technologies as well as...

PotM: CliCr® - an innovative click reagent

Herein, we present CliCr® as an innovative cyclic alkyne for metal-free...

Acylation Efficiencies on Ser and Thr Pseudoproline Monomers

In two joint studies together with Prof. F. Albericio we investigated the...

Review – Product Highlights 2022

Curious about our latest portfolio additions from July to December 2022 and...

Incorporation of pseudoproline monomer (Fmoc-Thr[ψMe,Mepro]–OH) facilitates efficient solid-phase synthesis of difficult peptides

Herein we investigate the incorporation of the Fmoc-Thr-pseudoproline monomer...

Abraligabra - Reagents and Building Blocks for Chemical Ligation

We can’t get enough of new products and innovations! Read this blog to get...

PotM: His Tags for the Chemical Modification of Peptides

Jensen et al. developed two methods that use poly-His sequences to direct the...

DTT and Spermidine for RNA Buffers and Vaccine Production

See how our “mRNA grade” DTT and Spermidine can support also your nucleic...

Everything for Nobel Chemistry

The 2022 Chemistry Nobel prize is awarded to B. Sharpless, M. Meldal and C....

PotM: Fmoc-Ser(Msbh)-OH

You are working on complex peptides and are looking for a new level of...

Process Development of SPPS

From mg synthesis of a peptide up to bulk quantities often makes a huge...

PotM: 1,4-Benzenedimethanethiol (BDMT)

1,4-Benzenedimethanethiol is used as thiol scavenger during solid-phase...

A Systematic Comparison of Different Methods to Tackle Aspartimide Formation

Read on for detailed information on the results of our comparative study on...

Solid-Phase Peptide Synthesis Using a Four-Dimensional (Safety-Catch) Protecting Group Scheme

As the molecular diversity of cyclic and branched peptides becomes more and...

Solid-Phase Synthesis of an “Inaccessible” hGH-Derived Peptide Using a Pseudoproline Monomer and SIT-Protection for Cysteine

Herein, we report the first-time SPPS of a special peptide sequence via...

PotM: Smoc Amino Acids

Herein, we present the Clean Peptide Technology using Smoc Amino Acids...

Resins for Solid Phase Peptide Synthesis (Part 2)

You want to get an overview about the various resins available at Iris...

Resins for Solid Phase Peptide Synthesis (Part 1)

You just started working in the field of solid phase (peptide) synthesis and...

PotM: Biotin – Desthiobiotin - Iminobiotin

Herein, we present 2-Iminobiotin, a cyclic guanidino analogue of biotin with...

The Dawson Linker

The Dawson Linker and its variants provide access to C-terminal peptide...

pH-Sensitive Self-Immolative Linkers

Are you active in the field of antibody drug conjugates? Click here to find...

PotM: A Lysine Multitool Building Block

The para-azido benzyloxycarbonyl protected lysine building block...

Photoswitches

Photoswitches grant the ability to modulate the function of a molecule by...

Workshop Polymer Therapeutics for Improved Drug Delivery

You missed our workshop featuring Prof. María Jesus Vicent Docón (Head of...

Dyes and Fluorescent Labels at Iris Biotech

Dyes and fluorescent labels are an invaluable tool for diagnostics, medical...

Peptide Easy Clean – Because Time Matters

We want to support you in the development of next generation peptide...

High (Enantiomeric) Purities

For selected products we added minimum purity and minimum enantiomeric purity...

Drug Delivery at Iris Biotech

Discover our products suitable for drug delivery including poly...

Custom Synthesis Services at Iris Biotech

Iris Biotech is your trusted partner in the world of peptides and all related...

PotM: Proteolysis Targeting Chimeras (PROTACs®)

Drug the undruggable – click here to get more information about the use of...

Fatty Acid Building Blocks

We are providing variously functionalized, protected and unprotected fatty...

Amino Acid Oxidation Products

Oxidation is not only a known degradation pathway of proteins and peptides in...

Chemically Tunable Kinetics of Self-Immolation

Discover our selection of disulfide-based self-immolative linkers allowing to...

Workshop Complex peptide manufacturing made easy with PEC

You missed our workshop featuring Dr. Nadja Berger and Dr. Manoj Kumar...

PotM: Functionalized Polysarcosines for the Formation of Lipid Nanoparticles: Towards Improved RNA Delivery

Interested in polymers for the delivery of promising drug candidates, e.g....

Sarcosine Building Blocks

Interested in the introduction of Sarcosine (N-methylglycine), e.g. for...

PotM: Propargyl Amino Acids for Click Position Screening

Discover our selection of propargyl-substituted amino acids and find the best...

iNoc – An Acid Stable Alternative to Cbz

Looking for an acid stable protecting group? Struggling with undesired loss...

Isotopically Labeled Drugs

Stable isotopically labeled drugs are routinely used to investigate a...

PotM: Substrates for Fusion (Halo/Snap/Clip)-Tagged Proteins

Discover our selection of substrates for Halo-, Snap-, and Clip-tagged...

Review – Product Highlights 2021

Herein, we summarize certain product highlights and innovations, which we...

Easy access to purified complex peptides on larger scales with the peptide easy clean technology – a liraglutide case study

With a remarkable amount of peptide therapeutics already on the market and...

Workshop Advances on Cysteine Protecting Groups

You missed our workshop featuring Prof. Dr. Fernando Albericio (University of...

N-Methylation of Amino-PEG-Acids

Herein we are reporting on the linker stability of amino-PEG-acids achieved...

Pseudoproline Monomers

Typically known and employed as preformed dipeptides, we are presenting...

PotM: About the Adamantyl Motif

Check out our growing portfolio on adamantyl-substituted amino acids and...

Haloalkane Dehalogenase Substrates

Discover our selection of Halo ligands as haloalkane dehalogenase substrates,...

Hydrazone Resins as Alternative to SEA Resins

Discover the versatile applications of hydrazone resins e.g. for the...

PotM: Seleno Amino Acids

Selenocysteine (Sec) plays a crucial role for various biological processes,...

Maillard Reaction Products – General Advice for Usage, Reconstitution and Storage

Read on for more information about the right handling of Maillard Reaction...

Protease Stable Ile/Leu Surrogates

Herein we are presenting 2-(Fmoc-amino)-3,3-diMe-pent-4-enoic acid (FAA5040),...

Measures to Prevent Aspartimide Formation

Aspartimide formation remains one major hurdle during peptide synthesis. Read...

PotM: Functionalized Biotinylation Reagents

Iris Biotech offers a variety of (functionalized) biotin and desthiobiotin...

N-Alkyl Substituted Carboxy Linkers for Peptide Synthesis

Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which...

Avoiding Racemization: Fmoc-Aaa-MPPAs as Alternatives for Wang Linker during SPPS

Compounds of the shown formula can simply be bound to solid supports via...

Trifluoromethylated Amino Acids

The incorporation of alpha-trifluoromethyl substituted amino acids into...

PotM: Methanoprolines and Dimethylprolines - Constraining the Conformation of Peptides

Interested in structure-activity studies of your Proline-containing peptide...

Clicky Acids – Fatty Acids for Click Conjugation

Iris Biotech offers various (protected) azide- and alkyne-modified fatty acid...

About the Advantages of Pseudoproline Dipeptides

Serine- and Threonine-derived oxazolidines as well as Cysteine-derived...

Thiol- and Amine Reactive Crosslinkers

Iris Biotech offers hetero-bifunctional crosslinkers bearing an...

PotM: Pyridyldithiols as Precursors for Disulfide-Based (Self-Immolative) Linkers

Read on to find out more about Iris Biotech’s Linkerology® portfolio...

Fmoc-L-Cys(Palm)-OH – A S-palmitoylated Cysteine building block

Interested in studying the effect of palmitoylation on your peptide’s...

Facilitating the synthesis of hydrophobic peptides and proteins

Cys(Aapam): an Alloc protected Phacm linker as removable side chain...

PotM: Guanidino-Proline as rigid Arginine mimic

Interested in structure activity studies on your Arginine containing peptide...

Fmoc-MeDbz-OH – Available on Large Scale

Are you using the Fmoc-MeDbz-OH Dawson Linker in large scale on a regular...

DACNs for Strain-Promoted Azide-Alkyne Cycloadditions (SPAAC)

Herein we present substituted diazacyclononynes (DACNs) as versatile tools...

PotM: Asp(CSY) – Tackling Aspartimide Formation

Fmoc-Asp(CSY)-OH – an innovative building block to suppress aspartimide...

Adamantyls are a Chemist’s Best Friend

The highly lipophilic, bulky adamantyl motif is a promising and validated...

Ramage Linker

An efficient, versatile linker developed for the synthesis of C-terminal...

Aminooxy-Amino Acid Derivatives

Herein, we present aminooxy-amino acids reported for peptide synthesis via...

Arginine Derivatives Suitable for Side-Chain Derivatization

Herein we present two arginine derivatives, in which the native guanidino...

Bulky Aspartate Protecting Groups to Avoid Aspartimide Formation

Frustrated by aspartimide formation during peptide synthesis? Iris Biotech...

PotM: SIT – A New Cysteine Protecting Group

The new disulfide-based protecting group sec-isoamyl mercaptan (SIT) is fully...

Cyclopropyl Modification

Cyclopropanes represent important design elements in medicinal chemistry and...

Trimethyl Locks

The sterical interference of three closely positioned methyl groups favors...

PotM: Disulfide-Based Self-Immolative Linkers

The linkage of a drug to its carrier via a disulfide-based self-immolative...

Linkerology

Check out our latest video summarizing our capabilities and knowledge on...

New Dawson Linker Derivatives

Interested in the formation of peptide thioesters for Native Chemical...

Amino-Methylcoumarins as Fluorescent Labels

Enzymatically-activatable probes based on 7-amino-4-methylcoumarin (AMC)...

Modifications of Methionine

Methionine is particularly prone to oxidation by atmospheric oxygen in vitro...

Product of the Month: Fluorinated Amino Acids

One approach for the design of bioactive peptides with improved...

Thiol-reactive Linkers for ADCs

The thiosuccinimide linkage is a prominent connective motif resulting from...

Product of the Month: Fluorescent SARS-CoV-2 Protease Substrates

Mpro is a key enzyme of coronaviruses (coronaviridae) and thus an attractive...

Deamino- and Decarboxy-Histidine Derivatives

Interested in histidine derivatives? Iris Biotech provides a selection of...

Fighting SARS-CoV-2

Fighting COVID-19 by modifying essential viral proteins via glycation through...

Product of the Month: Imatinib And Other Linked Kinase Inhibitor Analogues

Iris Biotech offers various linked kinase inhibitors including analogues of...

Valine-Citrulline Based Enzymatically Cleavable Linkers

Iris Biotech presents its selection of Val-Cit-based linkers, a dipeptide...

Nitrodibenzofuran (NDBF) based Photocleavable Protecting Groups

Nitrodibenzofuran (NDBF) is a photocleavable side chain protecting group that...

(Functionalized) Fullerenes of Versatile Value

Iris Biotech presents (functionalized) fullerenes of different core size (C60...

Product Focus: IPTG

Isopropyl-β-D-thiogalactopyranoside (IPTG) is one of the most commonly...

Product of the Month: Novel Fmoc-Amino Acids for Convenient Access to HDAC Inhibitors

Find out more about those building blocks with side chains able to coordinate...

Product Focus: TT-232, a Potent Somatostatin Analogue

Amongst various somatostatin analogues, the pentacyclic heptapeptide TT-232...

New Collaboration with SciClix

Find out more about our partner SciClix from Singapore and our new...

Identification and Quantification of Maillard RPs

Find out which Maillard Reaction Products from Iris Biotech were used in the...

Product of the Month: Dde-based Linkers

Placing Dde as one terminal group of a linker and a functional group prone...

Subject Focus: Linkerology

The ever-growing sophistication and variation in linker design have given...

Alkyne Amino Acids for Click Chemistry and other Conjugations:

Alkyne amino acids allow for Click conjugations and other types of chemistry....

Product of the Month: cyclo-Arg-Gly-Asp (RGD) Peptides

The integrin receptor interacting RGD sequence and related peptides act as...

Product of the Month: “Cleland’s Reagent” Dithiothreitol (DTT)

DTT is a powerful yet mild reducing agent. Based on your demand we can offer...

PotM: Peptide Easy Clean (PEC)

Peptide purification after SPPS usually requires time- and solvent-consuming...

Lipidated Amino Acids

The tremendous success of Liraglutide and Semaglutide has moved amino acids...

PotM: Bicyclo[1.1.1]pentanes as Phenyl Ring Bioisosteres

The presence of phenyl groups in APIs is connected with various...

Statement on COVID-19

Beginning of March 2020 Iris Biotech implemented measures in order to...

Betulins – Potent Natural Products

Betulin and its derivatives are pentacyclic triterpenoids of the lupane-type....

27th SCT Young Research Fellows Meeting

29 - 31 January 2020

2nd Alpine Winter Conference on Medicinal and Synthetic Chemistry

19 - 23 January 2020

Short arginine analogs: peptide synthesis prediction of biological effects

Arginine, a semi-essential amino acid, is involved in various important...

Cleavable Bifunctional Biotin-Linkers

Biotinylation of proteins and their purification via Streptavidin beads is a...

Product of the Month: Biotin-Aniline for Proximity Labeling of RNA

Proximity labeling of proteins with biotin-phenol (biotin-tyramide) and an...

MedChem 2019

22 November 2019

Product of the Month: Fmoc-L-Cys(Allocam)-OH for 1-Step On-Resin Disulfide Bond Formation

The Allocam protecting group allows for selective deprotection and disulfide...

Diazirine Amino Acids: Photocrosslinking Applications

Two selected publications were summarized in this article in order to...

7th Modern Solid Phase Peptide Synthesis & Its Applications Symposium

5 - 7 September 2019

APS - American Peptide Symposium 2019

22 - 27 June 2019

14th Annual Drug Discovery Chemistry

9 - 11 April 2019

Protease Inhibitors

Protease inhibitors are molecules that inhibit protease function by binding...

10th International Peptide Symposium

3 - 7 December 2018

Fmoc-L-Lys(Nvoc)-OH

o-Nitroveratryloxycarbonyl (Nvoc) is a photocleavable side chain protecting...

(TPP-Lys(TPP))2-Lys-Gly-Gly-Gly-N2H3*4Br*TFA

Delivery of hydrophilic compounds across membranes is usually problematic....

Product of the Month: Indocyanine Green (ICG) Dyes

Indocyanine Green (ICG) dye, a material approved by the FDA for various...

A Cyclo-RGD Peptide for the Preparation of Tumor Mimics

The 2D monolayer cell culture model is widely applied for drug screening....

16th Naples Workshop on Bioactive Peptides

June 7-9, 2018Aula Magna Partenope, Centro Congressi “Federico...

Diazirine Amino Acids for Photo Cross-Linkage in Living Cells

Iris Biotech introduces a comprehensive set of photo-crosslinking amino acids...

Fmoc-Amox, A Novel Reagent for Fmoc-Protection

The most common reagent for the Fmoc-protection of amino acids is currently...

beta,beta-Dimethyl Amino Acids

The use of bioactive peptides has increased over the recent years as they...

Polyarginine

Polyarginines are well known for their ability to enhance cell penetration.

Fmoc-L-Cys(Propargyl)-OH

This alkyne-functionalized cysteine building block can be incorporated into...

Proline Scaffold

One role of proline in proteins is that a β-turn of a peptide chain is being...

Fmoc Deprotection Reagents

The Fmoc group is the most frequently used protecting group in peptide...

Standard Fmoc Amino Acid Building Blocks

Amino acids of high quality are crucial for the synthesis of peptides with a...

Polylysines

Polylysines are polymers of the canonical amino acid Lysine, and are...

10th Peptoid Summit

10 - 11 August 2017

RICT 2017 - Drug Discovery & Selection

5 - 7 July 2017

10th Joint Meeting on Medicinal Chemistry, Croatia.

25 - 28 June 2017

APS American Peptide Symposium, Canada

17 - 22 June 2017

Mercapto-PEG-Acids for Bioconjugation

Mercapto-PEG-Acids are highly hydrophilic, non-antigenic, non-immunogenic and...

1st Generation Click Chemistry

Azido and alkyne functions can cyclise by an intramolecular CuI or Cu0...

2nd Generation Click Chemistry

Recombinant Incorporation of Amino Acids into Proteins

Mutant or modified aminoacyl tRNA synthetases (aaRS) have been used to charge...

Peptide Structure Stabilization by Click Chemistry

As Boc and Fmoc protected derivatives of both azido and alkyne amino acids...

Azido-Masked Amino Function

Click Chemistry in DNA Synthesis

Click Chemistry in DNA Synthesis - Applications and Procedures in DNA Synthesis

Specific platforms

Asymmetric Phase-Transfer Reaction Phase-transfer alkylations e.g. with the...

α-Methyl and β,β-dimethyl amino acids

α-Methyl and alkyl-amino acids can be produced by a number of platforms,...

Arginine Analogues

Trypsin (EC 3.4.21.4), an endopeptidase and natural protease found in the...

Specific Linkers

The variations for linkers are endless, as in our catalogue program already...

Polydispersity of Polymer Carriers

The polymers in this context are a polymeric linear structures with n...

Comparison of Carriers for Polymer Therapeutics

The polymers in this context are a polymeric linear structures with n...

Poly(Glutamic Acid) as Versatile Biodegradable Drug Carrier

Polyglutamates are well known to be highly biocompatible, biodegradable and...

Polysarcosine – a True Alternative to PEG

Potential alternatives to PEGs, polypeptoids in general and polysarcosine...

Poly(Ethylene Glycol) – the Pioneer in Polymer Therapeutics

PEGs show a spectrum of unique physical and chemical properties, which have...

Amino-PEG-Acids and their Active Esters

Amino protected amino-PEG-acids can be used for the PEGylation of solid...

Lipoamide-PEGs Confer Extra Strong Binding

Nanotechnology and nanobiotechnology using gold or silver particles, quantum...

Polymers Enlarge the Potential of Biopharmaceuticals

The Biopharmaceuticals market, estimated at US$ 200 billion globally in 2013...

Pharmacological Effects of Polymer Therapeutics

Small drug molecules and also large biomolecules like proteins or antibodies...

A Three-Dimensional Quantitative Structure-Activity Relationship (3D-QSAR) Model for Predicting the Enantioselectivity of Candida antarctica Lipase B

Lysine Dendrons

We now offer a series of Lysine dendrons for chemoselective functionalization...

Coupling Reagents for Peptide Chemistry

In this news section, we highlight three useful coupling reagents for peptide...

PEG-Conjugates of Folic Acid and Cholesterol

Conjugates of PEG and folic acid or cholesterol, respectively, combine the...

Triamino Acids

Fmoc-L-Dap(2-Boc-aminoethyl)-OH is the first in a series of new triamino acid...

The 7th World ADC Conference

10-13 October 2016San Diego, CA, USAMarriot Marquis & Marina

Photocleavable NCL-Auxiliary Glycine

This innovative auxiliary facilitates Native Chemical Ligation at the...

Omniligase-1 for Efficient Peptide Ligation

Omniligase-1 enables efficient and racemization-free ligation of two...

The Safety-Catch Acid-Labile (SCAL)-Linker

The SCAL linker offers superior chemical stability and permits a variety of...

New Iris Kits for the Synthesis of Peptoids and N-Alkylated Peptides

Peptides as pharmaceutical compounds suffer from unfavorable pharmacokinetics...

Third Chemical Ligation Meeting

May 26th-27th, 2016Lille, France The third Chemical Ligation Meeting is a...

Chlorotoxin & Biotin-Chlorotoxin

Chlorotoxin is a chloride channel blocker which has been found in the venom...

3rd Generation Click Chemistry: Tetrazine and TCO Derivatives for Copper-free Conjugation

The reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) is the...

Fast and Easy Protease Kinetics with Asymmetric Rhodamine 110 Substrates

Asymmetric Rhodamine 110 protease substrates are used for the determination...

3rd Annual Peptides Congress, London

April 18th-19th, 2016London, UK Scientific discussions about the current...

Furyl-Alanine: A Novel Photo-Click Amino Acid

2-Furyl-alanine can be incorporated into peptides via SPPS or by using...

Targeted and Reversible Biotinylation with Biotin-SS-Tyramide

Our new Biotin-SS-Tyramide linker is a valuable tool for peroxidase-promoted...

Fmoc-Phe-Aca: Fluorescent Internalization Reporter for Cell Penetrating Peptides (CPPs)

The Fmoc-L-Phe-Aca pseudo-dipeptide is a useful reporter group for the...

Inexpensive & High Quality Guanylation Reagents

We now offer N,N'-Bis-Boc-N"-triflylguanidine, at both a very...

Siderophore Building Block: New Hydroxamate-Ornithine for Fmoc/tBu SPPS

Nδ-hydroxy-Nδ-acetyl-ornithine, an important constituent of many...

Click Chemistry Tools: Propargyl Amino Acids

Click chemistry is a convenient method to chemoselectively functionalize...

Canalin and Canavanine : New Fmoc building blocks for novel peptides and protein analogs

5-oxa-Derivatives of Orn and Arg, respectively, these rare amino acids are...

5th Modern Solid Phase Peptide Synthesis & Its Applications Symposium

October 22 to 25, 2015Ramada Couran Cove Island Resort, South Stradbroke...

The 11th Australian Peptide Conference

October 25 to 30, 2015Peppers Salt & Spa, Kingscliff, NSW,...

The 6th World ADC Conference

October 19 to 21, 2015Sheraton San Diego Hotel & Marina, San Diego, CA,...

New: Oligo Glycine – Linker

Oligo-glycines are either flexible linkers or form well defined rigid...

NGlyO – for beta sheet formation

Surprising behavior of NXO-peptides. It is a significant property of peptides...

NEW Hydrazone Resin

A new hydrazone resin enables a convenient way to synthesize peptide...

9th Peptoid Summit

August, 6th - 7th, 2015Molecular Foundry, Lawrence Berkeley National...

Peptoids - Peptide Backbone Derivatisation

Alkylating the Nitrogen of an amide bond results in peptoid structures,...

6th EuChem for Life Sciences

June 10th - 12th, 2015Reitoria of Universidade Nova de LisboaCampus de...

Peptide Solutions Appointed as Distributor for Iris Biotech for all North American Sales

We at Iris Biotech, are pleased to announce that we have entered into an...

New Statin Analogues: Super-Threonine Derivatives

A set of new statin analogues, so called Super-Threonines, is available...

Bioheterocycles 2015 - XVI International Conference on Heterocycles in Bioorganic Chemistry

June 8th - 11th, 2015University of Lorraine, Campus du SaulcyMetz, France The...

2nd NovAliX Conference Biophysics in Drug Discovery 2015

June 9th - 12th, 2015Palais UniversitaireStrasbourg, France The use of...

4-Methylbenzhydryl-Resins - the Better Wang-Resin alternative

Wang resins are widely used for peptide synthesis. However, certain side...

New: Cysteine-Pseudoproline

Pseudoprolines derived from Serine and Threonine have developed to standard...

Forum Life Science 2015

  March 11th-12th, 2015Technische Universität...

Non-canonical amino acids in proteins: structural investigations and biocatalysis

February 10th, 2015DECHEMA-HausFrankfurt/Main, Germany   The one-day...

MedChem 2014

November 21st, 2014Llyod Conference Room, UCB PharmaBraine-L'Alleud, Belgium...

The NEW Iris Biotech Catalogue is available now!

In the era of internet a printed edition of a catalogue still has some...

Custom Synthesis of Alkyne Amino Acids Analogues for Click Conjugation

1,4-substituted 1,2,3-triazole are isosteric to peptide bonds and result in...

Custom Synthesis of Click-able compounds for Cu-free Click Conjugation

The presence of catalytic copper, limits the in vivo application of the Click...

Custom Synthesis of beta & gamma Amino Acids including Statine Analogues

GABA is a neurotransmitter in the central nervous system of mammals and its...

Preloaded Resins for Synthesis of Peptide Amides

Used for Efficient and Economic Bulk Synthesis of Peptide APIs: A new...

Benzotriazole Amino Acids

Benzotriazol activated carboxylic acids: Fast reaction (within minutes) at...

RICT 2014 - 50th International Conference on Medicinal Chemistry

July 2nd - 4th, 2014Rouen’s Law FacultyRouen, Normandy, France The...

14th Naples Workshop on Bioactive Peptides

June 12th - 14th, 2014Centro Congressi of University of Naples "Frederico...

Bis-Boc-guanidinopyrazole

Arginine rich peptides show increased interest during the last years as they...

Aspartic and Glutamic Acid Homologues

Arginine rich peptides show increased interest during the last years as the...

10th International Symposium on Polymer Therapeutics

May 19th - 21th, 2014Centro de Investigación Príncipe...

Biotin Tyramide Reagents for Tyrosine-/Protein-Biotinylation

Tyramine compounds are converted to highly reactive radicals by horseradish...

Bis-Mal-Lysine

Bis Thiol & Amine reactive PEGylated Cross-Linker which has been used for...

MiDye is YOUR Dye!

Superior Performance at a Sensational Price! Available as –COOH, -NHS,...

Diamines & Polyamines

Compounds like putrescine, spermidine, and spermine play important roles in a...

Ellmans Reagent

DTNB, frequently called Ellman’s Reagent, used as reagent for determination...

BIO 2013 – The Global Event for Biotechnology

April 22-25, 2013McCormick Place, Chicago, Illinois Iris Biotech GmbH will...

Product of the Month: Fmoc-L-Cys(Dpm)-OH

Any amino acid can be functionalized on the N-terminus with oxalic acid and...

Perfluorophenyl azides as Photo Cross-Linker

Aryl azides are well-known precursors of nitrenes and have been introduced by...

2-(Fmoc-amino)-3-azidobutanoic acid

Building Blocks for the synthesis of 2,3-diaminobutanoic acid containing...

A Total New Game for the Synthesis of Disulfide-Containing Peptides

The overall goal of our research is to capitalize on peptides of natural...

32nd European Peptide Symposium

September 2nd - 7th, 2012Athens, GreeceMegaron Conference Centre   With...

13th Belgian Organic Synthesis Symposium BOSS XIII

July 15th - 20th, 2012Leuven, Belgium The BOSS-conference is a unique...

48th International Conference on Medicinal Chemistry (RICT 2012)

July 04th-06th, 2012Poitiers, France This major international symposium will...

Bio Convention 2012

June 18th-21st, 2012Boston, USA Iris Biotech GmbH will participate...

4th International Conference on Drug Discovery and Therapy

February 12th - 15th, 2012Dubai, UAE This unique international...

4-Azido-L-homoalanine

H-L-Aha-OH*HClH-L-Dab(N3)-OH 4-Azido-L-homoalanine(S)-2-Amino-4-azidobutanoic...

DTT (Cleland's Reagent)

Cleland's reagent, also known as dithiothreitol or DTT is a water soluble...

Troc-OSu

Reported applications: Introduction of 9-fluorenylmethyloxycarbonyl,...

Green Advantages of using Phacm for Cystein Protection

PGA (Penicillin G Amidase, Penicillin Acylase, Penicillin Amidohydrolase from...

Dendron Building Blocks for Click Chemistry

Dendrimers offer a new possibility to derivatize small molecules, surfaces or...

Understanding enzyme immobilisation

PEGylation - The Magic Wand IRIS Biotech GmbH - Turning Proteins and other Biopharmaceuticals into Super Performing Block Busters

Abstract: In 2006 the market of modern biopharmaceuticals has reached a...

Hexafluoroacetone as Protecting and Activating Reagent: New Routes to Amino, Hydroxy, and Mercapto Acids and Their Application for Peptide and Glyco- and Depsipeptide Modification

Abstract: A considerable number of biologically active naturally occurring...

Preparation of D-amino acids by enzymatic kinetic resolution using a mutant of penicillin-G acylase from E. coli

From Production of Peptides in Milligram Amounts for Research to Multi-Tons Quantities for Drugs of the Future

Peptides are key to modern drug discovery. This article reviews the...

Resin-bound mercapto acids: synthesis and application.

Mercapto acids were attached through their thiol group onto 2-chlorotrityl...