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Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying through a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.
Continue to Iris Biotech GmbHSend request to US distributorChemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-tetrahydropyranyl-L-cysteine // Synonyms: Fmoc-Cys(Thp)-OH, (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tetrahydro-2H-pyran-2-ylthio)propanoic acid
from €350.00
Tetrahydropyranyl (Thp), a new S,O-acetal nonaromatic protecting group for cysteine, which has been shown to be superior to Trt, Dpm, Acm, and StBu in solid-phase peptide synthesis using the Fmoc/tBu strategy. Cys racemization and C-terminal 3-(1-piperidinyl)-alanine formation were minimized when the Cys was protected with Thp accompanied by improved solubility of Cys-containing protected peptides. Complete deprotection can be carried out with either TFA/TIS/DCM (10:1.5:88.5) within 5 min or with HCl/dioxane (12:88)in 2h.
Tetrahydropyranyl, a Nonaromatic Acid-Labile Cys Protecting Group for Fmoc Peptide Chemistry; I. Ramos-Tomillero, H. Rodriguez and F. Albericio; Organic Letters 2015; 17: 1680-1683. doi:10.1021/acs.orglett.5b00444
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