Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Quick contact
Please send me more information about
Fmoc-L-Cys(Thp)-OH
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-tetrahydropyranyl-L-cysteine // Synonyms: Fmoc-Cys(Thp)-OH, (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tetrahydro-2H-pyran-2-ylthio)propanoic acid
- Product code:FAA4160
- CAS No.:1673576-83-4
- Formula:C23H25NO5S
- Storage temperature:-20°C
- Molecular weight:427.15 g/mol
from €350.00
description
Tetrahydropyranyl (Thp), a new S,O-acetal nonaromatic protecting group for cysteine, which has been shown to be superior to Trt, Dpm, Acm, and StBu in solid-phase peptide synthesis using the Fmoc/tBu strategy. Cys racemization and C-terminal 3-(1-piperidinyl)-alanine formation were minimized when the Cys was protected with Thp accompanied by improved solubility of Cys-containing protected peptides. Complete deprotection can be carried out with either TFA/TIS/DCM (10:1.5:88.5) within 5 min or with HCl/dioxane (12:88)in 2h.
references
Tetrahydropyranyl, a Nonaromatic Acid-Labile Cys Protecting Group for Fmoc Peptide Chemistry; I. Ramos-Tomillero, H. Rodriguez and F. Albericio; Organic Letters 2015; 17: 1680-1683. doi:10.1021/acs.orglett.5b00444
* Disclaimer
We refer to our general terms and conditions.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
Do you need further information about this product?
get in contact
Brochures & Flyers
We found other products you might like!
