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Blog - Amino Acids - Page 4
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Automated Peptide Synthesis
The discovery of the Merrifield peptide synthesis paved the way for automated solid-phase peptide synthesis (SPPS) enabling fast and convenient simultaneous peptide synthesis.
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PotM: Small-sized, neutral fluorogenic amino acids suitable for SPPS
Discover our small-sized, neutral Fmoc-protected nitrobenzoselenadiazole- and nitrobenzothiadiazole-modified amino acids suitable for SPPS of fluorescent peptides.
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PotM: Next Generation Lysine Side Chain Protecting Groups
Sick of Lysine side chain protecting groups jumping around, yielding scrambled peptides? Check our various options to fine-tune protecting group stability vs. cleavability to optimize your peptide yield.
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Process Development – From Discovery to Scale-up
Ongoing research efforts lead to the discovery of innovative building blocks and new APIs. However, for industrial applications, upscaling is required. Herein, we share the process development for Fmoc-Cys(Msbh)-OH.
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Cyanobenzothiazole (CBT) Derivatives for “Click” Conjugation
Discover the cyanobenzothiazole (CBT) click reaction, a not (yet) so well-known biocompatible and bio-orthogonal mechanism faster than the famous azide-alkyne cycloaddition (CuAAC).
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PotM: Safety Catch - Orthogonally Protected Amino Acids
Add a new dimension of orthogonality to your peptide synthesis by using Safety-Catch arylalkyl sulfoxide protecting groups! This newsletter tells you about benefits and usage – Read on!
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Photoaffinity Labeling by Diazirine Building Blocks
Discover our diazirine-substituted building blocks suitable for the analysis of protein-protein and RNA-protein interactions via proximity labeling upon photoactivation. Read on for more information!
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Carbamidomethylated Cysteine as SPPS Building Block
Our building block Fmoc-L-Cys(Cam)-OH enables peptides resembling reduced and carbamido-methylated protein fragments by standard SPPS without error-prone modification reactions.
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Fatty Di-Acids
Peptide therapeutics – fewer injections/lower doses by prolonging their half-life via addition of a lipid modification that promotes binding to serum proteins such as albumin. Read on for recent innovations!
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Non-canonical Tryptophan Derivatives
Non-canonical Tryptophan analogs can help to improve your API’s performance in terms of potency, specificity, and stability. We offer various substituted Trp derivatives also available in small quantities for screening.
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