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Amino Acids
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Photocleavable NCL-Auxiliary Glycine
This innovative auxiliary facilitates Native Chemical Ligation at the position of a Glycine residue in a peptide sequence. The auxiliary can be further functionalized, e.g. by PEGylation. Following NCL, the auxiliary is removed by irradiation with UV light.
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Msbh, a Safety Catch Cysteine Protecting Group for the Synthesis of Cyclic Peptides
The regioselective formation of multiple disulfide bonds is often a synthetic challenge. We now offer an innovative safety-catch Cys protecting group that allows selective deprotection of the sulfhydryl group and is a valuable addition to the peptide chemist’s toolbox.
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Furyl-Alanine: A Novel Photo-Click Amino Acid
2-Furyl-alanine can be incorporated into peptides via SPPS or by using enzymatic approaches. UV-irradiation in the presence of oxygen and a photosensitizer converts furyl-alanine to an intermediate that selectively reacts with certain nucleophiles. This property can be employed for site-specific labeling of peptides and proteins.
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Siderophore Building Block: New Hydroxamate-Ornithine for Fmoc/tBu SPPS
Nδ-hydroxy-Nδ-acetyl-ornithine, an important constituent of many siderophores, is now available for your convenience as Nα-Fmoc-Nδ-(acetyl)-Nδ-(benzoyloxy)-ornithine building block which can be used in standard Fmoc/tBu SPPS and permits facile on-resin Nδ-deprotection.
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Click Chemistry Tools: Propargyl Amino Acids
Click chemistry is a convenient method to chemoselectively functionalize peptides at specific positions. We offer a variety of different propargyl amino acids for both Fmoc and Boc strategies, for enzymatic synthesis, as well as preloaded resins for SPPS.
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Canalin and Canavanine : New Fmoc building blocks for novel peptides and protein analogs
5-oxa-Derivatives of Orn and Arg, respectively, these rare amino acids are produced by legumes as protection against herbivores. For your convenience, we offer building blocks of both amino acids compatible with standard Fmoc/tBu SPPS chemistry
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New Substituted Ornithine Derivatives
l-Ornithine derivative containing peptides play important roles in SAR studies, enzyme inhibition and cancer research. We now offer a variety of Nδ-substituted ornithines containing heterocyclic, aromatic and aliphatic groups, as well as N-substituted C3- and C4-analogs of ornithine.
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Locked and Loaded: Prepacked Fmoc-Amino Acids for ABI Synthesizers
Pre-packed amino acid cartridges for ABI peptide synthesizers are available for you convenience. Speed up your peptide syntheses with our cartridges containing all 20 standard amino acids for Fmoc/tBu chemistry.
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Getting Bulky
Bulky glycine analogs are interesting molecules for creating peptide derivatives with certain biological activities, e.g. with antiviral properties. Furthermore, they are useful compounds for protein structure evaluation.
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New: Guanidino-Glycine
Visit our Glycine section and find a series of amino acid derivatives, where oxazole is the characteristic structural element carrying carboxy and amino function.
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