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Product Focus
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Phenyl-, Cyclohexyl- and BCP-Amino Acids
Sidechain-derivatized amino acids have shown great potential in enhancing select properties of peptide lead compounds. Find the most recent additions to our portfolio of amino acids bearing additional aryl and alkyl groups in their side chains.
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Lipidated Amino Acids
The tremendous success of Liraglutide and Semaglutide has moved amino acids modified with lipids into the focus of many research endeavors. Delve into the treasure trove of our lipidated amino acids!
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Betulins – Potent Natural Products
Betulin and its derivatives are pentacyclic triterpenoids of the lupane-type. They are natural products that occur as secondary metabolites in over 200 different plants. Betulinic acid (BA) is a derivative of betulin that is oxidized at C-28.
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Cleavable Bifunctional Biotin-Linkers
Biotinylation of proteins and their purification via Streptavidin beads is a widely applied method.
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Diazirine Amino Acids: Photocrosslinking Applications
Two selected publications were summarized in this article in order to highlight the impressive utility of amino acids incorporating the diazirine photophore.
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Protease Inhibitors
Protease inhibitors are molecules that inhibit protease function by binding either reversibly or irreversibly to the enzyme.
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Membrane-Impermeant Biotin Tyramide
Methods for proteomic mapping of cellular organelles or subdomains that avoid the necessity of cell lysis and purification by targeting specific subcellular regions have several advantages.
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Fmoc-L-Lys(Nvoc)-OH
o-Nitroveratryloxycarbonyl (Nvoc) is a photocleavable side chain protecting group for lysine that can be removed by irradiation with UV light (350 nm).
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H-L-Lys(Suc)-OH*HCl
Succinylation of proteins on the epsilon-amino group of lysine residues is a posttranslational modification that is still poorly understood.
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(TPP-Lys(TPP))2-Lys-Gly-Gly-Gly-N2H3*4Br*TFA
Delivery of hydrophilic compounds across membranes is usually problematic. Modification with triphenylphosphonium ions has been shown to overcome this barrier.
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