Blog - Life Sciences - Page 6

New Statin Analogues: Super-Threonine Derivatives

A set of new statin analogues, so called Super-Threonines, is available consisting of Fmoc protected L-enantiomers with all possible 4 stereoisomers of chiral centers in the side chain. They appear in nature as bridge building element in cyclodepsipeptides, like pipecolidepsin A, a compound which shows relevant cytotoxic activity in three human tumor cell lines (lung, colon, breast) and has unique structural features.

Luciferin for Research and Industry – from MG to KG Scale

In modern biotechnology there are numerous applications for the luminogenic luciferase assay. We supply luciferin from mg scale for research applications like monitoring of gene expression or tumor growth up to kg quantities for hygiene surveillance in food industry

MiDye is YOUR Dye!

Superior Performance at a Sensational Price!

• Available as –COOH, -NHS, -Maleimide, -Alkyne, -Azide
• Half the price of other well-known dyes like Alexa- & Cy-Dyes.
• Available also in large quantities.
• Broadly applied in cell imaging, FRET, fluorescence quenching.

Acyl-Carnitine

Long-chain acylcarnitines are well-known intermediates in mitochondrial fatty acid oxidation

Coelenterazines – very versatile Luminophores

A prominent luciferase group was first discovered in Coelenterata and the corresponding light emitting molecule was therefore named coelenterazine.

MiDye550-Alkyne

• Readily applicable to biolabelling, Click 
  conjugation protocols and peptide synthesis
• Stable under buffer conditions (pH 4-8) 
  and in solid phase peptide synthesis
• Broadly applied in cell und animal 
  imaging, tested in FRET systems
• Available in larger quantities compared 
  to e.g. Alexa, Cy-Dyes etc.
• Purities > 85%, supplied as freeze-dried solid powder

Actiplus-CALB

Lipase B from Candida antarctica (EC 3.1.1.3)
adsorbed on hydrophobic polymer Polystyrene DVB cross linked, 300-700µm,
Synthetic Activity >10.000 U/g (dry), 
very high mechanical stability - suitable for packed bed reactors

Understanding enzyme immobilisation

Preparation of D-amino acids by enzymatic kinetic resolution using a mutant of penicillin-G acylase from E. coli