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Blog | Page 27
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PotM: Disulfide-Based Self-Immolative Linkers
The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.
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Linkerology
Check out our latest video summarizing our capabilities and knowledge on linker technologies
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New Dawson Linker Derivatives
Interested in the formation of peptide thioesters for Native Chemical Ligation? Read on to find out more about the use of Dawson Linker derivatives as thioester surrogates compatible with Fmoc SPPS.
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Amino-Methylcoumarins as Fluorescent Labels
Enzymatically-activatable probes based on 7-amino-4-methylcoumarin (AMC) represent versatile tools for the detection and localization of proteolytic enzyme activities. Read on to find out more.
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Modifications of Methionine
Methionine is particularly prone to oxidation by atmospheric oxygen in vitro but also by reactive oxygen species in vivo, resulting in the corresponding sulfoxide and sulfone. Read on to find out more.
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Product of the Month: Fluorinated Amino Acids
One approach for the design of bioactive peptides with improved pharmacological properties is the derivatization of amino acid building blocks with fluorine. Find out more about the advantages of fluorinated peptides.
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Thiol-reactive Linkers for ADCs
The thiosuccinimide linkage is a prominent connective motif resulting from the reaction of a thiol and an alkyl maleimide. Read on to learn more about its applications and potential improvements.
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Product of the Month: Fluorescent SARS-CoV-2 Protease Substrates
Mpro is a key enzyme of coronaviruses (coronaviridae) and thus an attractive drug target. Iris Biotech offers fluorescent substrates, which can be used to perform various types of screenings and to identify potential inhibitors of COVID-19.
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