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Arginine Derivatives Suitable for Side-Chain Derivatization
Herein we present two arginine derivatives, in which the native guanidino group is replaced by an isosteric amino-functionalized carbamoylated guanidino group that can serve as an attachment point for further derivatization.
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Bulky Aspartate Protecting Groups to Avoid Aspartimide Formation
Frustrated by aspartimide formation during peptide synthesis? Iris Biotech presents aspartate derivatives with bulky side chain protecting groups that minimize the formation of aspartimide-related side-products.
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PotM: SIT – A New Cysteine Protecting Group
The new disulfide-based protecting group sec-isoamyl mercaptan (SIT) is fully compatible with Fmoc- and Boc-SPPS and can easily be removed reductively upon addition of dithiothreitol.
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Cyclopropyl Modification
Cyclopropanes represent important design elements in medicinal chemistry and are widely present in drug compounds. Read on to find out more about their full potential.
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Trimethyl Locks
The sterical interference of three closely positioned methyl groups favors amide cleavage and payload release upon lactonization. This cascade can be induced by various triggers. Read on to find out more.
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