Product Focus

Structural Element: Aminoisobutyric Acid and Homologues

Aminoisobutyric acid (Aib) and its homologues are a strong helix promoters in peptide mimetics. Aib-containing model peptides are already used in cancer treatment, antimicrobial peptides and cell penetrating peptides (CPP).

We offer Aib and its homologues positioning the dimethyl fragment either close to the N- or to the C-terminus.

Synthesis of Protected Peptide Amide Fragments with Sieber Resin

Fmoc-Sieber amide resin is an acid-labile carrier for solid phase synthesis of peptide amides. Cleavage with only 1% TFA makes it an ideal carrier for the synthesis of protected peptide fragments in fragment condensation strategies for the synthesis of long peptides.

Amino-PEG-Acids for Increased Solubilization.

For introducing amino-PEG-acids into a peptide chain, several affordable building blocks are available with all conventional protecting groups. They can be incorporated at any sequence position by standard coupling protocols.

Custom Synthesis of beta & gamma Amino Acids including Statine Analogues

GABA is a neurotransmitter in the central nervous system of mammals and its deficiency is associated with severe neurological disorders. Statine, a GABA analogue, occurs in several peptide APIs.

Derivatives of gamma-amino acid analogues are of continued vital interest for a variety of applications in medicinal chemistry.

We have a tool box available to offer a broad range of substituted gamma-amino acids and statines on custom synthesis basis.

Preloaded Resins for Synthesis of Peptide Amides

Used for Efficient and Economic Bulk Synthesis of Peptide APIs:

A new technology is available with a set of new preloaded resins, which enable the synthesis of peptide amides WITHOUT ANY LINKER.
Amino acid amides, which bear a functional side chain, are immobilized on acid sensitive resins. This makes process development, small scale synthesis, bulk production and in-process control very easy.

Find more technical details in our application for demonstration purposes with BIVALIRUDIN.

Benzotriazole Amino Acids

Benzotriazol activated carboxylic acids:

• Fast reaction (within minutes) at room temperature with amines and other nucleophiles under addition of base (in both water and non- aqueous solvents).
• Stable to racemization when coupling with nucleophiles.
• High solubility in organic solvents like DMF and DCM.
• Stable in water.

Luciferin for Research and Industry – from MG to KG Scale

In modern biotechnology there are numerous applications for the luminogenic luciferase assay. We supply luciferin from mg scale for research applications like monitoring of gene expression or tumor growth up to kg quantities for hygiene surveillance in food industry

New: dPEG-Phospholipids for superior liposomes

Novel liposomes built of dPEG-Phospholipids with defined PEG chain length provide prolonged blood-circulation time and improved cellular uptake as administration carriers for drugs, delivering active molecules to the desired target.

Aspartic and Glutamic Acid Homologues

Arginine rich peptides show increased interest during the last years as the have the capability to cross cell and blood brain barrier membranes.

New Click Linker

Click chemistry has developed to a widely used conjugation technique. Here are our latest developments of new short linker for hydrophilic and hydrophobic applications.