Product Focus

Thio-Prolines - Rigid Homo-Cys Analogues

Cysteins and homocysteins are found in many natural and artificial peptide sequences. Mercaptoproline is a rigid analogue of homocysteine offering several options to the medicinal chemist.

Biotin Tyramide Reagents for Tyrosine-/Protein-Biotinylation

Tyramine compounds are converted to highly reactive radicals by horseradish peroxidase in presence of H2O2 which preferentially react with surface exposed tyrosines. Biotin Tyramide and Biotin-PEG-Tyramide therefore are ideal reagents used for tyrosine-/protein-biotinylation.

Prolines with Hydrophobic Substituents

Prolines are key elements positioned at the edge of β-turns in peptides. With modified prolines these positions can be used for either covalent amide or disulfide bonds – as we have demonstrated in many examples – or for filling hydrophobic pockets, whenever the pyrrolidine ring is substituted with groups like Methyl or Phenyl.

MiDye is YOUR Dye!

Superior Performance at a Sensational Price!

• Available as –COOH, -NHS, -Maleimide, -Alkyne, -Azide
• Half the price of other well-known dyes like Alexa- & Cy-Dyes.
• Available also in large quantities.
• Broadly applied in cell imaging, FRET, fluorescence quenching.

Diamines & Polyamines

Compounds like putrescine, spermidine, and spermine play important roles in a many biological functions. Many of them are excellent targets for oncology studies and other fields of medicinal chemistry.
Find in our new brochure Diamines & Polyamines our possibilities for custom synthesis and a set over 100 available derivatives.

Green Advantages of using Phacm for Cystein Protection

PGA (Penicillin G Amidase, Penicillin Acylase, Penicillin Amidohydrolase from E.coli on acrylic resin, Systematic name: Penicillin amidohydrolase, E.C. 3.5.1.11) has an active pocket, which is very specific for phenyl acetic acid. The prominent commercial use is hydrolysis of a phenylacetamid bond during production of the penicillin API 6-APA (De Martin et al., J. Mol. Catal. B:Enzymatic 1999; 6: 437). The high specifity of PGA towards the Phenylacetyl moiety makes the use of Phacm as new alternative for Acm very promising. The principle use already was discovered by Albericio et al in 1995 using native PGA. Today PGA is available as immobilized preparation, so by simple filtration process PGA can be removed from the reaction mixture and reused many times.

Dendron Building Blocks for Click Chemistry

Dendrimers offer a new possibility to derivatize small molecules, surfaces or biopharmaceuticals with a monodisperse macromolecule and alter in this way properties like solubility and hydrophilicity. Immunogenicity and pharmacokinetics of pharmaceuticals will be improved. The synthetic approach for designing these dendrons of different generations is based on 2,2-bis(hydroxymethyl) propionic acid, which is a non-toxic and biocompatible building block.

The size can be designed from 250 g/mole for 1st generation dendrons to over 4400 g/mole with 5th generation compounds. Dendrimers can be designed reaching even a molecular weight of some 10.000 Da. As focal point alkyne and azido functions are used with appropriate counter parts in any type of click chemistry reaction. Olefinic functions offer the possibility for addition reaction or conjugation by metathesis reactions or photo reactions with the aid of UV light. For the modification of Gold surfaces sulphur bearing dendrons can be used, they also conjugate with biologicals via disulfide bridge formation.