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Boc-2-Aic
Chemical name: 2-((tert-Butoxycarbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid // Synonyms: Boc-2-aminoindane-2-carboxylic acid
- Product code:BAA4760
- CAS No.:71066-00-7
- Formula:C15H19NO4
- Molecular weight:277.32 g/mol
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description
This derivative can be used as constrained phenylalanine building block for structure activity relationship studies. Such alpha,alpha-disubstituted amino acids are widely used in peptide design because of their structure promoting effects.
references
Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analog: effects on receptor selectivity and stereospecificity; P. W. Schiller, G. Weltrowska, N. Tai Mai Dung, C. Lemieux, N. N. Chung, B. J. Marsden, B. C. Wilkes; J. Med. Chem. 1991; 34(10): 3125-3132. https://doi.org/10.1021/jm00114a023.
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