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Fmoc-Ac6c(4,4-F2)-OH
Chemical name: 1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4,4-difluorocyclohexane-1-carboxylic acid // Synonyms: 1-(Fmoc-amino)-4,4-difluorocyclohexane-1-carboxylic acid
- Product code:FAA8620
- CAS No.:1986905-26-3
- Formula:C22H21F2NO4
- Molecular weight:401.41 g/mol
from $750.00
description
This derivative can be used as constrained building block for structure activity relationship studies. Furthermore, the carbon-fluorine bond is characterized by a special hydrophobic character with a high dipole moment providing unique properties to the synthesized molecule thus rendering this derivative a promising building block for drug discovery.
references
Fluorine in Peptide Design and Protein Engineering; C. Jäckel and B. Koksch; Eur J. Org. Chem. 2005; 21: 4483-4503. https://doi.org/10.1002/ejoc.200500205.
Fluorinated Proteins: From Design and Synthesis to Structure and Stability; E. N. G. Marsh; Acc. Chem. Res. 2014; 47: 2878-2886. https://doi.org/10.1021/ar500125m.
Applications of fluorine-containing amino acids for drug design; H. Mei, J. Han, K. D. Klika, K. Izawa, T. Sato, N. A. Meanwell, V. A. Soloshonok; Eur. J. Med. Chem. 2020; 186: 111826. https://doi.org/10.1016/j.ejmech.2019.111826.
Synthesis and Antimalarial Activities of Several Fluorinated Artemisinin Derivatives; Y. Ming Pu, D. S. Torok, H. Ziffer, X.-Q. Pan, S. R. Meshnick; J.
Med. Chem. 1995; 38(20): 4120-4124. https://doi.org/10.1021/jm00020a028.
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