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Fmoc-Ac8c-OH
Chemical name: 1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)cyclooctane-1-carboxylic acid // Synonyms: 1-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]cyclooctanecarboxylic acid
- Product code:FAA8675
- CAS No.:222166-38-3
- Formula:C24H27NO4
- Molecular weight:393.48 g/mol
from $375.00
description
This derivative can be used as constrained building block for structure activity relationship studies. Such alpha,alpha-disubstituted amino acids are widely used in peptide design because of their structure promoting effects.
references
Preptin Analogues: Chemical Synthesis, Secondary Structure and Biological Studies; C. M. Buchanan, Z. Peng, A. Cefre, V. Sarojini; Chem. Biol. Drug Des. 2013; 82(4): 429-437. https://doi.org/10.1111/cbdd.12168.
Peptide helices with pendant cycloalkane rings. Characterization of conformations of 1-aminocyclooctane-1-carboxylic acid (Ac8c) residues in peptides; J. Pept. Sci. 2004; 10(3): 160-172. https://doi.org/10.1002/psc.507.
Agonist Activity at the Kinin B1 Receptor: Structural Requirements of the Central Tetrapeptide; P. Rovero, M. Pellegrini, A. Di Fenza, S. Meini, L. Quartara, C. A. Maggi, F. Formaggio, C. Toniolo, D. F. Mierke; J. Med. Chem. 2001; 44(2): 274-278. https://doi.org/10.1021/jm000319u.
A New Clas of Pseudopeptide Antagonists of the Kinin B1 Receptor Containing Alkyl Spacers; C. Galoppini, S. Meini, M. Tancredi, A. Di Fenza, A. Triolo, L. Quartara, C. A. Magi, F. Formaggio, C. Toniolo, S. Mazzucco, A. Papini, P. Rovero; J. Med. Chem. 1999; 42(3): 409-414. https://doi.org/10.1021/jm980495r.
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