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Fmoc-2-Aic
Chemical name: 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-1,3-dihydroindene-2-carboxylic acid // Synonyms: Fmoc-2-aminoindane-2-carboxylic acid, 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dihydro-1H-indene-2-carboxylic acid
- Product code:FAA8660
- CAS No.:135944-07-9
- Formula:C25H21NO4
- Molecular weight:399.45 g/mol
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description
This derivative can be used as constrained phenylalanine building block for structure activity relationship studies. Such alpha,alpha-disubstituted amino acids are widely used in peptide design because of their structure promoting effects.
references
Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analog: effects on receptor selectivity and stereospecificity; P. W. Schiller, G. Weltrowska, N. Tai Mai Dung, C. Lemieux, N. N. Chung, B. J. Marsden, B. C. Wilkes; J. Med. Chem. 1991; 34(10): 3125-3132. https://doi.org/10.1021/jm00114a023.
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