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PotM: Argpyrimidine Building Block for SPPS
Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!
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Choose your Taste – Functionalized Halo/Snap/Clip Substrates
The HaloTag®, SNAP-Tag® and CLIP-TagTM represent versatile tools for the specific, covalent attachment of in principle any molecule of choice to a protein of interest. Discover our substrates!
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Temporary Activity Masking via Self-Immolative Linkage
(Bi)functional dioxoborolane and disulfide-based self-immolative linkers – mode of action and application examples for the detection of H2O2, for prodrug design, and reversible peptide cyclization.
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Let’s Talk Iris
You want to get an overview about the different Click technologies as well as available derivatives and applications? Let’s arrange a (virtual) talk by Iris Biotech about your topic of choice – Contact us!
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PotM: CliCr® - an innovative click reagent
Herein, we present CliCr® as an innovative cyclic alkyne for metal-free strain-promoted click chemistry. Read our blog for detailed information about CliCr® reagents based on TMTHSI and check out available derivatives!
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Acylation Efficiencies on Ser and Thr Pseudoproline Monomers
In two joint studies together with Prof. F. Albericio we investigated the coupling efficiencies of Ser and Thr pseudoproline monomers and their use for the synthesis of inaccessible peptide sequenes. Read on!
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Review – Product Highlights 2022
Curious about our latest portfolio additions from July to December 2022 and the 2022’s overall product and newsletter highlights? Click here to check out the summary or get in contact for more details!
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Incorporation of pseudoproline monomer (Fmoc-Thr[ψMe,Mepro]–OH) facilitates efficient solid-phase synthesis of difficult peptides
Herein we investigate the incorporation of the Fmoc-Thr-pseudoproline monomer during Fmoc SPPS. Typically, pseudoprolines are incorporated as preformed dipeptides. However, the possibility of using the monomer adds flexibility to the synthesis.
Read more![Incorporation of pseudoproline monomer (Fmoc-Thr[ψMe,Mepro]–OH) facilitates efficient solid-phase synthesis of difficult peptides](https://cdn.iris-biotech.de/media//_cache/images/blog/610/Publikation_Dez2022.png)
