Blog | Page 43

09/02/2017

Specific Linkers

The variations for linkers are endless, as in our catalogue program already hundreds of different derivatives are available for conjugation of small molecules, biomolecules and surfaces to each other.

Custom Synthesis

09/02/2017

Spermines, spermidines and other Polyamines

Polyamines such as ethylene diamine and its higher homologues are important feedstocks for the chemical industry. Compounds like putrescine, spermidine, and spermine play important roles in both eukaryotic and prokaryotic cells and show many other different biological functions.

Custom Synthesis

09/02/2017

Maillard Reaction Products

Proteins contained in meat and other comestible goods are usually rich in the amino acids arginine and lysine. The side chain func- tional groups of Arg and Lys react with reducing carbohydrates such as glucose or lactose to form Amadori reaction products.

Drug Delivery

07/02/2017

Polydispersity of Polymer Carriers

The polymers in this context are a polymeric linear structures with n repeating units of monomers. Depending whether the polymer is consisting of one single molecular weight (only one n existing) or of a range of compounds with an average mass and a distribution of n around a mean value, polymers are referred to as “monodisperse” or “polydisperse”.

Drug Delivery

07/02/2017

Comparison of Carriers for Polymer Therapeutics

The polymers in this context are a polymeric linear structures with n repeating units of monomers. Depending whether the polymer is consisting of one single molecular weight (only one n existing) or of a range of compounds with an average mass and a distribution of n around a mean value, polymers are referred to as “monodisperse” or “polydisperse”.

Drug Delivery

07/02/2017

Poly(Glutamic Acid) as Versatile Biodegradable Drug Carrier

Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have already been used as building blocks in polymer drug conjugates and polymeric micelles.

Drug Delivery

07/02/2017

Polysarcosine – a True Alternative to PEG

Potential alternatives to PEGs, polypeptoids in general and polysarcosine (PSR) in particular stand out in terms of safety, synthetic control and versatility.

Drug Delivery

07/02/2017

Poly(Ethylene Glycol) – the Pioneer in Polymer Therapeutics

PEGs show a spectrum of unique physical and chemical properties, which have been described in literature extensively by the pioneers in PEGylation: Harris, Veronese and recently by Hermanson. Here are summarized the most common known properties.

Drug Delivery

07/02/2017

Amino-PEG-Acids and their Active Esters

Amino protected amino-PEG-acids can be used for the PEGylation of solid particles in order to create hydrophilic and reactive surfaces with no non-specific binding issues.

Drug Delivery

07/02/2017

Lipoamide-PEGs Confer Extra Strong Binding

Nanotechnology and nanobiotechnology using gold or silver particles, quantum dots or even magnetic particles are broadly diverse, rapidly expanding areas of study in medical diagnostics and therapeutics, sensoric and chemistry.