Blog | Page 65

Shorter Arginine homologues to stabilize peptides towards tryptic digestion

Abstract: Trypsin digests peptides at the position of arginine. Because shorter homologues of arginine with appropriate protecting groups for conventional Fmoc/tBu peptide synthesis are now available, three model peptides containing arginine and two shorter homologues of arginine were synthesized.

PEGylation - The Magic Wand IRIS Biotech GmbH - Turning Proteins and other Biopharmaceuticals into Super Performing Block Busters

Abstract: In 2006 the market of modern biopharmaceuticals has reached a volume of over 3 billion in USA and over billion world wide (IMS Health, Inc.).

Hexafluoroacetone as Protecting and Activating Reagent: New Routes to Amino, Hydroxy, and Mercapto Acids and Their Application for Peptide and Glyco- and Depsipeptide Modification

Abstract: A considerable number of biologically active naturally occurring products are peptides, depsipeptides, and peptide conjugates.

Preparation of D-amino acids by enzymatic kinetic resolution using a mutant of penicillin-G acylase from E. coli

From Production of Peptides in Milligram Amounts for Research to Multi-Tons Quantities for Drugs of the Future

Peptides are key to modern drug discovery. This article reviews the requirements for bulk production of peptides and how it affects research and production of smaller scales.

Resin-bound mercapto acids: synthesis and application.

Mercapto acids were attached through their thiol group onto 2-chlorotrityl (Clt)-, trityl (Trt)-, 4-methyltrityl (Mtt)-, 4-methoxytrityl (Mmt)-, and 4,4'-dimethoxytrityl (Dmt)-resins.

Preparation of the very acid-sensitive Fmoc-Lys(Mtt)-OH. Application in the synthesis of side-chain to side-chain cyclic peptides and oligolysine cores suitable for the solid-phase assembly of MAPs and TASPs

Abstract: N alpha-9-Fluorenylmethoxycarbonyl-N epsilon-4=methyltrityl-lysine, [Fmoc-Lys(Mtt)-OH], was prepared in two steps from lysine, in 42% overall yield.