Versatility of N3-AEEA, a short, monodiosperse Azido-PEG-carboxylic acid

Published on 24/01/2013

The azido function can be used for different applications

The azido function can be used for different applications:

The azido group can be reduced to an amino function and here by serve as masked amino group. It is of particular use, if additional orthogonalities are needed. Azido is stable towards treatment with piperidine (Fmoc deprotection), Pd(0) (Alloc removal) and acidic treatment (cleavage of Mtt, Trt or other acid sensitive groups).
The azido function can also be used for any type of click conjugation with any available alkynyl residue forming click conjugates.

PEG2780