We now offer the standard guanylation reagent N,N'-Bis-(t-butyloxycarbonyl)-N"-triflylguanidine at both a very competitive price and our habitual high quality. 

Additionally, for your convenience we offer N,N'-Bis-(t-butyloxycarbonyl)-1-guanylpyrazole as well as N,N-Bis(benzyloxycarbonyl)-1-guanylpyrazole. 

Guanidine-containing molecules are interesting targets for medicinal chemists. A convenient method for the introduction of guanidino groups is the guanylation of amino groups.

One of the many uses of guanylation reagents is in the synthesis of Arginine-rich (or Arg-homolog-rich) peptides. The most common Arg-protecting group Pbf usually requires extended reaction times for deprotection. As a rule of thumb, the peptide chemist has to calculate one additional hour per Pbf group, which prolongs and complicates the synthesis of Arg-rich peptides.

An alternative strategy is the use of Mtt- or Mmt-protected Lysine. Both protecting groups can be removed quickly and under relatively mild reaction conditions, followed by the guanylation of Lysine to form Arginine. Similarly, homologs of Lysine such as Ornithine can be used to introduce the corresponding Arginine-homolog.

→ Find our guanylation reagents as well as protecting groups, coupling reagents, linkers, solvents and much more in our Reagents section.

→ Our portfolio encompasses 166 Lysine building blocks, 68 different Ornithine building blocks, 76 Diamino Butyric Acid (Dab) variants and 91 Diamino Propionic Acid (Dap) variants.

• Toward Understanding the Cationicity of Defensins: Arg and Lys Versus Their Noncoded Analogs; G. Zou, E. de Leeuw, C. Li, M. Pazgier, C. Li, P. Zeng, W.-Y. Lu, J. Lubkowski and W. Lu; Journal of Biological Chemistry 2007; 282: 19653-19665. doi:10.1074/jbc.M611003200