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Argpyrimidine
Chemical name: (S)-2-amino-5-(5-hydroxy-4,6-dimethylpyrimidin-2-ylamino)pentanoic acid trifluoroacetic acid salt
- Product code:HAA3050
- CAS No.:195143-52-3
- Formula:C11H18N4O3
- Molecular weight:254.29 g/mol
from $375.00
description
Maillard Reaction Products (MRPs) are indicators for the heat treatment of food, as well as markers of nutritional quality. They also appear naturally in the human body as so-called Advanced Glycation End Products (AGEs). As such, they are indicators for body health and disease processes, including inflammation, diabetes, cancer and ageing. Consequently, AGEs gained broad attention in cosmetics, biochemistry, food, and pharmaceutical applications.
This material is supplied as a salt containing varying contents of the acid counterion. The net content of each batch is specified in the respective certificate of analysis.
references
Antioxidant properties of argpyrimidine; N. Sreejayan, X. Yang, K. Palanichamy, K. Dolence and J. Ren; Eur J Pharmacol 2008; 593: 30-5. https://doi.org/10.1016/j.ejphar.2008.07.030
Therapeutic potential of breakers of advanced glycation end product-protein crosslinks; S. Vasan, P. Foiles and H. Founds; Archives of biochemistry and biophysics 2003; 419: 89-96. https://doi.org/10.1016/j.abb.2003.08.016
Argpyrimidine, a methylglyoxal-derived advanced glycation end-product in familial amyloidotic polyneuropathy; R. Gomes, M. Sousa Silva, A. Quintas, C. Cordeiro, A. Freire, P. Pereira, A. Martins, E. Monteiro, E. Barroso and A. Ponces Freire; The Biochemical journal 2005; 385: 339-45. https://doi.org/10.1042/BJ20040833
Argpyrimidine, a blue fluorophore in human lens proteins: high levels in brunescent cataractous lenses; P. S. Padayatti, A. S. Ng, K. Uchida, M. A. Glomb and R. H. Nagaraj; Invest Ophthalmol Vis Sci 2001; 42: 1299-304.
N(delta)-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-l-ornithine, a novel methylglyoxal-arginine modification in beer; M. A. Glomb, D. Rosch and R. H. Nagaraj; J Agric Food Chem 2001; 49: 366-72. https://doi.org/10.1021/jf000493r
Methylglyoxal modification of protein. Chemical and immunochemical characterization of methylglyoxal-arginine adducts; T. Oya, N. Hattori, Y. Mizuno, S. Miyata, S. Maeda, T. Osawa and K. Uchida; J Biol Chem 1999; 274: 18492-502. https://doi.org/10.1074/jbc.274.26.18492
Protein modification by methylglyoxal: chemical nature and synthetic mechanism of a major fluorescent adduct; I. N. Shipanova, M. A. Glomb and R. H. Nagaraj; Archives of biochemistry and biophysics 1997; 344: 29-36. https://doi.org/10.1006/abbi.1997.0195
Novel modifications of Nα-boc-arginine and Nα-CBZ-lysine by methylglyoxal; Y. Al-Abed, T. Mitsuhashi, P. Ulrich and R. Bucala; Bioorganic & Medicinal Chemistry Letters 1996; 6: 1577-1578. https://doi.org/10.1016/s0960-894x(96)00276-4
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