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Dpd-d4
Chemical name: (+)-Deoxypyridinoline-d4 trifluoroacetic acid salt // Synonyms: 1-((5S)-5-amino-5-carboxy-2,2,3,3-tetradeutero-pentyl)-4-((S)-2-amino-2-carboxyethyl)-3-((S)-3-amino-3-carboxypropyl)-5-hydroxypyridinium trifluoroacetate
- Product code:HAA4010
- Formula:C18H25D4N4O7
- Molecular weight:417.47 g/mol
from $1,125.00
description
Maillard Reaction Products (MRPs) are indicators for the heat treatment of food, as well as markers of nutritional quality. They also appear naturally in the human body as so-called Advanced Glycation End Products (AGEs). As such, they are indicators for body health and disease processes, including inflammation, diabetes, cancer and ageing. Consequently, AGEs gained broad attention in cosmetics, biochemistry, food, and pharmaceutical applications.
This material is supplied as a salt containing varying contents of the acid counterion. The net content of each batch is specified in the respective certificate of analysis.
references
Practical syntheses of pyridinolines, important amino acidic biomarkers of collagen health; P. Allevi, R. Cribiu, E. Giannini and M. Anastasia; J Org Chem 2007; 72: 3478-83. https://doi.org/10.1021/jo070136g
Bone collagen cross-links: an efficient one-pot synthesis of (+)-pyridinoline and (+)-dexoypyridinoline; M. Adamczyk, D. D. Johnson and R. E. Reddy; Tetrahedron: Asymmetry 2000; 11: 2289-2298. https://doi.org/10.1016/s0957-4166(00)00195-6
First total synthesis of the bone resorption markers deoxypyridinoline and hydroxypyridinoline; R. Waelchli, C. Beerli, H. Meigel and L. Révész; Bioorganic & Medicinal Chemistry Letters 1997; 7: 2831-2836. https://doi.org/10.1016/s0960-894x(97)10084-1
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