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Fmoc-L-Thr(tBu)-MPPA
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-threonine-3-(4-oxymethylphenoxy)propionic acid // Synonyms: 3-(4-(((N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyl)-L-threonyl)oxy)methyl)phenoxy)propanoic acid, O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-threonine[4-(2-carboxyethoxy) phenyl]methyl ester, Fmoc-Thr(tBu)-MPPA
- Product code:LW01702
- CAS No.:864876-97-1
- Formula:C33H37NO8
- Molecular weight:575.66 g/mol
from $118.75
description
This Fmoc-amino acid-MPPA linker serves as precursor for the linkage to e.g. aminomethyl supports by standard coupling procedures. By this method, a low (max 0.5%) and reproducible epimerization level of the C-terminal amino acid in your peptide is guaranteed.
references
Improved approach for anchoring Nalpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis; F. Albericio, G. Barany; Int. J. Peptide. Protein. Res. 1985; 26(1): 92-97. https://doi.org/10.1111/j.1399-3011.1985.tb03182.x.
Amino acid derivatives used as agents bonding to a solid support; NeoMPS S.A. 2005; French Patent Application FR 0402973, International Patent Application WO2005/095332.
Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality; K.-Y. Hung, P. W. R. Harris, A. Desai, J. F. Marshall, M. A. Brimble; Eur. J. Med. Chem. 2017; 136: 154-164. https://doi.org/10.1016/j.ejmech.2017.05.008.
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