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Fmoc-L-Val-MPPA
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-valine-3-(4-oxymethylphenoxy)propionic acid // Synonyms: 3-(4-((((((9H-fluoren-9-yl)methoxy)carbonyl)-L-valyl)oxy)methyl)phenoxy)propanoic acid, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valine-[4-(2-carboxyethoxy)phenyl]methyl ester,Fmoc-Val-MPPA
- Product code:LW02002
- CAS No.:864876-78-8
- Formula:C30H31NO7
- Molecular weight:517.58 g/mol
from $93.75
description
This Fmoc-amino acid-MPPA linker serves as precursor for the linkage to e.g. aminomethyl supports by standard coupling procedures. By this method, a low (max 0.5%) and reproducible epimerization level of the C-terminal amino acid in your peptide is guaranteed.
references
Improved approach for anchoring Nalpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis; F. Albericio, G. Barany; Int. J. Peptide. Protein. Res. 1985; 26(1): 92-97. https://doi.org/10.1111/j.1399-3011.1985.tb03182.x.
Amino acid derivatives used as agents bonding to a solid support; NeoMPS S.A. 2005; French Patent Application FR 0402973, International Patent Application WO2005/095332.
Synthesis and Evaluation of Novel TLR2 Agonists as Potential Adjuvants for Cancer Vaccines; B. L. Lu, G. M. Williams, D. J. Verdon, P. R. Dunbar, M. A. Brimble; J. Med. Chem. 2020; 63(5): 2282-2291. https://doi.org/10.1021/acs.jmedchem.9b01044.
Native Chemical Ligation via N-Acylurea Thioester Surrogates Obtained by Fmoc Solid-Phase Peptide Synthesis; J. Palà-Puljadas, J. B. Blanco-Canosa; Int. J. Pept. Res. Ther. 2012; 18: 63-70. https://doi.org/10.1007/978-1-0716-0434-2_7.
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