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Fmoc-L-Ser(tBu)-MPPA
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-t-butyl-L-serine-3-(4-oxymethylphenoxy)propionic acid // Synonyms: 3-(4-(((N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyl)-L-seryl)oxy)methyl)phenoxy)propanoic acid,O-(1,1-Dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine-[4-(2-carboxyethoxy)phenyl ]methyl ester, Fmoc-Ser(tBu)-MPPA
- Product code:LW01602
- CAS No.:864876-96-0
- Formula:C32H35NO8
- Storage temperature:2-8°C
- Molecular weight:561.63 g/mol
from $118.75
description
This Fmoc-amino acid-MPPA linker serves as precursor for the linkage to e.g. aminomethyl supports by standard coupling procedures. By this method, a low (max 0.5%) and reproducible epimerization level of the C-terminal amino acid in your peptide is guaranteed.
references
Improved approach for anchoring Nalpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis; F. Albericio, G. Barany; Int. J. Peptide. Protein. Res. 1985; 26(1): 92-97. https://doi.org/10.1111/j.1399-3011.1985.tb03182.x.
Amino acid derivatives used as agents bonding to a solid support; NeoMPS S.A. 2005; French Patent Application FR 0402973, International Patent Application WO2005/095332.
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