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Building Blocks
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PotM: Safety Catch - Orthogonally Protected Amino Acids
Add a new dimension of orthogonality to your peptide synthesis by using Safety-Catch arylalkyl sulfoxide protecting groups! This newsletter tells you about benefits and usage – Read on!
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Photoaffinity Labeling by Diazirine Building Blocks
Discover our diazirine-substituted building blocks suitable for the analysis of protein-protein and RNA-protein interactions via proximity labeling upon photoactivation. Read on for more information!
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Carbamidomethylated Cysteine as SPPS Building Block
Our building block Fmoc-L-Cys(Cam)-OH enables peptides resembling reduced and carbamido-methylated protein fragments by standard SPPS without error-prone modification reactions.
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PotM: Plant-Derived Cholesterol for LNP Drug Delivery
Plant-derived Cholesterol of high and consistent product quality in accordance with Pharmacopoeia requirements to replace established animal source material in LNP formulation. Read on!
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CliCr® - a Reactive and Soluble Bioorthogonal Click Reagent
Building blocks with a strained triple bond do not require copper catalysis when used in click chemistry. Discover CliCr®: improved solubility in aqueous conditions and high reactivity! Click here!
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Fatty Di-Acids
Peptide therapeutics – fewer injections/lower doses by prolonging their half-life via addition of a lipid modification that promotes binding to serum proteins such as albumin. Read on for recent innovations!
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Maleimide Crosslinkers
Maleimides provide versatile options for connecting payloads to proteins and other biomolecules. Discover how our bifunctional thiol reactive crosslinkers can support your project. Read on!
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PotM: Perfluorobiphenyl Building Blocks for Site-Selective Cysteine Conjugation
Herein, we present functionalized perfluorobiphenyl building blocks which can be used for site-selective π-clamp mediated cysteine conjugation. Read on for more details about this general method!
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PotM: Argpyrimidine Building Block for SPPS
Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!
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PotM: CliCr® - an innovative click reagent
Herein, we present CliCr® as an innovative cyclic alkyne for metal-free strain-promoted click chemistry. Read our blog for detailed information about CliCr® reagents based on TMTHSI and check out available derivatives!
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