Related products

Poly-arginines (PARs) are a class of poly(amino acids) that are a valuable alternative to PEGs. Unlike PEGs, polyarginines are biocompatible and biodegradable, so they do not accumulate in the body or cause an immune response. PARs can be used as carriers for pharmaceuticals, or for the multivalent presentation of molecules. They are well known for their ability to enhance cell penetration and to inhibit protein aggregation. Other applications are e.g. the formation of nano capsules. Iris Biotech offers PARs of different lengths (20 to 200 units).

Poly-glutamic acid (PGA) is a biocompatible and biodegradable polymer which can be conjugated through side chain condensation with any suitable molecule. Due to a controlled proprietary and patented process with living polymerization technology a superior quality of PGA is achieved. Usual poly amino acids carry significant amounts of cyclic structures, carbamates, or isocyanates. Through a very well controlled polymerization process, well defined terminal groups and polymeric structures are achieved in high purity and with superior polydispersity.

Poly-lysines (PLys) are polymers of the canonical amino acid lysine and are characterized by their high charge density caused by the presence of one free amino group per lysine monomer. Thus, this functional group can also serve as an attachment point for further functionalization. PLys are a valuable alternative to PEGs. Poly-lysines are biocompatible and biodegradable, so they do not accumulate in the body or cause an immune response. PLys can be used as carriers for pharmaceuticals, or for the multivalent presentation of molecules.

Poly-ornithines (PORs) are a class of poly(amino acids) that are a valuable alternative to PEG. Poly-ornithines are biocompatible and biodegradable, so they do not accumulate in the body or cause an immune response. PORs can be used as carriers for pharmaceuticals, or for the multivalent presentation of molecules. This selection offers PORs of different lengths, from 20 to 200 ornithine units.

Polysarcosine (PSR) – originating from the natural, non-toxic amino acid sarcosine (N-Methylglycine) – is the simplest polypeptoid and a newly rediscovered biocompatible and degradable polymer. Polysarcosine has been employed in a number of drug delivery systems, including dendrimers, polymer micelles, polyplexes, protein conjugates and micro- and nanoparticles, polymersomes and nanotubes. However, widespread use of PSR has been hampered by lack of commercially-available functional PSR in good quality. The use of PSR with functional head- and tail-groups for bioconjugation is comparable to the well-known PEGylation technology.

Poly(2-oxazoline)s (POxs) are innovative alternatives to classical poly(ethylene glycols). Poly(2-oxazoline)s are biocompatible, nontoxic, antimicrobial, antifungal and antifouling. Both termini of a POxs may be equipped with different functional groups. Furthermore, there is a large variety of possible side chains. This opens up the possibility to fine-tune the physicochemical properties of Poly(2-oxazoline)s. Iris Biotech already offers a selection of POxs, and will, of course, provide you with an offer for custom-made Poly(2-oxazoline)s as well.