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Visit this regularly updated section to check out the latest additions to our portfolio, as well as the latest developments at Iris Biotech.
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Alpha-Sulfo-beta-Alanine
alpha-Sulfo-beta-Alanine has been used to couple to hydrophobic labels like Cyanine and Rhodamine dyes and other hydrophobic residues to increase their solubility in water. As di- or tripeptide a further increase of hydrophilicity can be achieved. Fmoc-beta-Ala(SO3H)-OH can be coupled in SPPS by standard phosphonium or uronium based coupling reagents. In high throughput technologies for DNA sequencing and genomics charge-modified dye-labeled dideoxynucleoside-5’-triphosphates were synthesized for ‘direct-load’ applications in DNA sequencing.
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Cross-Linker: Mal-AMCHC-OSu
Mal-AMCHC-OSu
trans-N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate
Formula: C16H18N2O6
Molecular Weight: 334,33 g/moleCAS: 64987-85-5
CODE: MAA1000
1g: EUR 300,- US$ 420,-
5g: EUR 1200,- US$ 1680,-Prices are in EUR, net, exw Germany, shipping not include
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Troc-OSu
Reported applications:
Introduction of 9-fluorenylmethyloxycarbonyl, trichloroethoxycarbonyl, and benzyloxycarbonyl amine protecting groups into O-unprotected hydroxylamino acids using succinimidyl carbonates; Anelka Paquet; Can. J. Chem.; 1982; 60: 976.
Widely Applicable Deprotection Method of 2,2,2-Trichloroethoxycarbonyl (Troc) Group Using Tetrabutylammonium Fluoride; Cheng-yuan Huanga; Ning Wanga; Katsumasa Fujikia; Yuji Otsukaa; Masao Akamatsua; Yukari Fujimotoa; Koichi Fukasea; Journal of Carbohydrate Chemistry 2010; 29(6): 289 – 298.
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DTT (Cleland's Reagent)
Cleland's reagent, also known as dithiothreitol or DTT is a water soluble protective reagent for sulfhydryl groups.
It reduces disulfide linkages to free sulfhydryl groups in proteins and enzymes.
It is a component of buffers used in protocols for the isolation and purification of proteins.DTT (racemic), Cleland's ReagentRead more
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Actiplus-CALB
Lipase B from Candida antarctica (EC 3.1.1.3)
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adsorbed on hydrophobic polymer Polystyrene DVB cross linked, 300-700µm,
Synthetic Activity >10.000 U/g (dry),
very high mechanical stability - suitable for packed bed reactors -
Green Advantages of using Phacm for Cystein Protection
PGA (Penicillin G Amidase, Penicillin Acylase, Penicillin Amidohydrolase from E.coli on acrylic resin, Systematic name: Penicillin amidohydrolase, E.C. 3.5.1.11) has an active pocket, which is very specific for phenyl acetic acid. The prominent commercial use is hydrolysis of a phenylacetamid bond during production of the penicillin API 6-APA (De Martin et al., J. Mol. Catal. B:Enzymatic 1999; 6: 437). The high specifity of PGA towards the Phenylacetyl moiety makes the use of Phacm as new alternative for Acm very promising. The principle use already was discovered by Albericio et al in 1995 using native PGA. Today PGA is available as immobilized preparation, so by simple filtration process PGA can be removed from the reaction mixture and reused many times.
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Dendron Building Blocks for Click Chemistry
Dendrimers offer a new possibility to derivatize small molecules, surfaces or biopharmaceuticals with a monodisperse macromolecule and alter in this way properties like solubility and hydrophilicity. Immunogenicity and pharmacokinetics of pharmaceuticals will be improved. The synthetic approach for designing these dendrons of different generations is based on 2,2-bis(hydroxymethyl) propionic acid, which is a non-toxic and biocompatible building block.
The size can be designed from 250 g/mole for 1st generation dendrons to over 4400 g/mole with 5th generation compounds. Dendrimers can be designed reaching even a molecular weight of some 10.000 Da. As focal point alkyne and azido functions are used with appropriate counter parts in any type of click chemistry reaction. Olefinic functions offer the possibility for addition reaction or conjugation by metathesis reactions or photo reactions with the aid of UV light. For the modification of Gold surfaces sulphur bearing dendrons can be used, they also conjugate with biologicals via disulfide bridge formation.
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